Results 41 to 50 of about 61,077 (198)

A Chiral Virus‐Like Nanoplatform That Broadly Mediates Antibiotic Delivery to the Brain for Bacterial Meningitis Therapy

Advanced Science, EarlyView.
Chiral virus‐mimicking mesoporous silica nanostructures (CVSNs) efficiently transport diverse antibiotics across the blood–brain barrier (BBB) into brain parenchyma and cerebrospinal fluid. By enhancing delivery to microglia and astrocytes, CVSNs improve antibiotic bioavailability and therapeutic efficacy against both Gram‐negative and Gram‐positive ...
Qianqian Xu, Xuting Zheng, Huinan Tong, Ying Liu, Xiaoxi Fan, Miao Xu, Ziyan Zhang, Li Zhang, Mingyan Liu, Ting Du, Heran Li, Guojun Liu   +11 more
wiley   +1 more source

An Overview of Neisseria meningitidis

, 2019
Neisseria meningitidis (the meningococcus) is a member of the normal nasopharyngeal microbiome in healthy individuals, but can cause septicemia and meningitis in susceptible individuals. In this chapter we provide an overview of the disease caused by N. meningitidis and the schemes used to type the meningococcus. We also review the adhesions, virulence
Hollingshead, S, Tang, C
openaire   +2 more sources

Plasma Membrane Lipid Asymmetry Dynamically Regulates Passive Diffusion

Advanced Science, EarlyView.
Passive diffusion enables hydrophobic molecules to cross the plasma membrane and exert their biological functions. This study demonstrates that plasma membrane lipid asymmetry, dynamically regulated by lipid scrambling, determines membrane permeability to lipophilic molecules and thereby modulates their cellular activities.
Jieming Ping, Wenliang Wang, Jinnuo Xu, Mengyun Yang, Ning Wu   +4 more
wiley   +1 more source

Neisseria meningitidis Serogroup X ST-5799 (ST-22 complex) in Turkey: A unique pediatric case

Human Vaccines & Immunotherapeutics, 2018
Although outbreaks of Neisseria meningitidis serogroup X occured in a couple of African countries, a limited number of serogroup X meningococcal cases were reported in America and Europe as well as Turkey.
Gönül Tanır, Yasemin Ozsurekci, Jay Lucidarme, Sevgi Yaşar Durmuş, Aiswarya Lekshmi, Özlem Akisoglu, Ahmet Emre Aycan, Ray Borrow, Mehmet Ceyhan   +8 more
doaj   +1 more source

Purification of Disassembled Capsid Protein by Hydroxyapatite Chromatography Enhances Virus‐Like Particle Recovery

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Virus‐like particles (VLPs) are a promising modality with extensive applications in prophylactic and therapeutic vaccine design. Human Papillomavirus (HPV) vaccines are one such example where VLP vaccine applications have led to the successful reduction in HPV‐associated diseases, such as cervical cancer.
Nicholas Samuelson, Nathaniel Parker, Shiyi Wang, Sara Daley, Aaron Cote, Michael A. Winters   +5 more
wiley   +1 more source

Genomics of Neisseria meningitidis

International Journal of Medical Microbiology, 2001
An important feature of disease caused by Neisseria meningitidis is the propensity to invade the meninges. Much progress has been made in our understanding of how this pathogen circumvents the physical properties of this cellular barrier. This review will address the new possibilities offered by the recent availability of meningococcal genome sequences.
openaire   +2 more sources

Meningococcal genetic variation mechanisms viewed through comparative analysis of Serogroup C Strain FAM18 [PDF]

, 2007
Copyright @ 2007 Public Library of ScienceThe bacterium Neisseria meningitidis is commonly found harmlessly colonising the mucosal surfaces of the human nasopharynx.
Parkhill Julian, Snyder, L., Rabbinowitsch, Ester, Davis, P., Rabbinowitsch, E, Claire Arrowsmith, Saunders, Nigel, Saunders, Nigel J., Barrell, B, Chillingworth, Tracey, Moule, Sharon, Tracey Chillingworth, Unwin, L., Bentley Stephen D, Maddison Mark, Jagels Kay, Vernikos George S, Saunders Nigel J, Maddison, Mark, Quail Michael A, Jagels, K, Unwin, Louise, Davis Paul H, Nancy E Holroyd, Maddison, M, Jagels, K., Chillingworth Tracey, Moule, S., Achtman, M., Mark Achtman, Unwin Louise, Unwin, L, Chillingworth, T., Quail, Michael A., Sharp Sarah, Stephen D Bentley, Rabbinowitsch Ester, Vernikos, GS, Julian Parkhill, Snyder Lori A. S, Vernikos, G., Moule, S, Arrowsmith Claire, Holroyd, NE, Parkhill, Julian, Snyder, Lori A.S., Carol Churcher, Holroyd, N., Churcher, Carol, Quail, M., Davis, PH, Churcher Carol, Achtman, M, Barrell, Bart, Quail, MA, Bart Barrell, Mark Maddison, Chillingworth, T, Parkhill, J, Moule Sharon, Arrowsmith, C, Churcher, C, Whitehead, Sally, Bentley, Stephen D., Nigel J Saunders, Barrell Bart, Arrowsmith, Claire, Arrowsmith, C., Cronin, A, Whitehead, S., Achtman, Mark, Snyder, LAS, George S Vernikos, Ester Rabbinowitsch, Louise Unwin, Churcher, C., Barrell, B., Jagels, Kay, Cronin, Ann, Cronin, A., Whitehead Sally, Bentley, SD, Saunders, NJ, Kay Jagels, Holroyd Nancy E, Bentley, S., Sharp, Sarah, Sharp, S., Rabbinowitsch, E., Parkhill, J., Lori A S Snyder, Paul H Davis, Sharp, S, Sally Whitehead, Achtman Mark, Maddison, M., Holroyd, Nancy E., Vernikos, George S., Davis, Paul H., Michael A Quail, Saunders, N., Whitehead, S, Ann Cronin, Cronin Ann, Sharon Moule, Sarah Sharp   +105 more
core   +2 more sources

Programmable three‐state nanoreactor for spatiotemporally controlled tumor therapy

BMEMat, EarlyView.
The OMVs are shielded with a biocompatible Da–Ca shell, which prolongs its circulation period and promotes intratumoral accumulation. Importantly, the biocompatible Da–Ca shell can be controllably disintegrated in tumor microenvironment by using laser irradiation, generating in situ hyperthermia and releasing Ca2+.
Guihong Lu, Peng Ye, Xiaoyan Li, Ke Ma, Chengliang Lyu, Kai Zhang, Ran Luo, Yang Ji, Shiqi Mei, Fan Zhang, Jinxie Zhang, Lin Mei, Hui Tan   +12 more
wiley   +1 more source

La Méningite à Méningocoque C dans la Zone d’Orpaillage Artisanale de N’tahaka, Région de Gao

Health Research in Africa
RÉSUMÉ Introduction. Les méningites bactériennes en Afrique subsaharienne sont dues essentiellement à Haemophilus influenzae b (Hib), Streptococcus pneumoniae (Spn) et Neisseria meningitidis (Nm).
Ibrahim Dollo, Youssouf Almoustapha Touré, Souleymane Mariko, Karim Dao, Abdoulaye Mamadou Traoré, Koké Touré, Mohamed Salaha Ousmane, Ibrahima Guindo, Garan Dabo, Hamadoun Guindo, Alhousseyni Coulibaly, Daouda Kassoum Minta   +11 more
doaj   +1 more source

MurNAc‐Based Electrophilic Inhibitors of O‐Acetylpeptidoglycan Esterase (Ape): Design, Synthesis, and Kinetic Evaluation

Chemistry – A European Journal, EarlyView.
A series of N‐acetylmuramic acid (MurNAc)‐based electrophilic inhibitors targeting Ape esterase was synthesized. Their inhibitory potency ranged from micromolar to submillimolar. The study probed binding contributions of stem peptide extension, replacing the anomeric methyl group with a benzyl, and α‐fluorination of the carbonyl to enhance ...
Dmytro Voskoboinyk, Martin E. Tanner
wiley   +1 more source