Results 11 to 20 of about 29,293 (218)

Cost‐effectiveness of second‐line therapies in adults with chronic immune thrombocytopenia

American Journal of Hematology, Volume 98, Issue 1, Page 122-130, January 2023., 2023
Abstract Major options for second‐line therapy in adults with chronic immune thrombocytopenia (ITP) include splenectomy, rituximab, and thrombopoietin receptor agonists (TRAs). The American Society of Hematology guidelines recommend rituximab over splenectomy, TRAs over rituximab, and splenectomy or TRAs while noting a lack of evidence on the cost ...
George Goshua, Pranay Sinha, Natalia Kunst, Lauren Pischel, Alfred Ian Lee, Adam Cuker   +5 more
wiley   +1 more source

Improved N‐acetylneuraminic acid bioproduction by optimizing pathway for reducing intermediate accumulation

Food Bioengineering, Volume 1, Issue 3-4, Page 205-211, December 2022., 2022
1. To eliminate the extensively accumulated by‐product N‐acetylglucosamine (GlcNAc), the UDP‐GlcNAc epimerase (NeuC) pathway without GlcNAc production was firstly reconstructed and optimized in Bacillus subtilis, and thereby NeuAc titer increased to 5.9 g/L and the by‐product GlcNAc was eliminated. 2.
Haoyu Guo, Rongzhen Tian, Chenyun Wang, Runzhi Zhao, Xueqin Lv, Long Liu, Yanfeng Liu   +6 more
wiley   +1 more source

Enzymatic Sialylation of Synthetic Multivalent Scaffolds: From 3′‐Sialyllactose Glycomacromolecules to Novel Neoglycosides

Macromolecular Bioscience, Volume 22, Issue 12, December 2022., 2022
The combination of solid phase polymer synthesis and enzymatic sialyation is used to yield multivalent stereoselective 3′‐sialyllactose‐presenting macromolecules. The one pot reaction using synthetase NmCSS and sialyltransferase PmST1 is suitable to transfer sialic acid to either glycan acceptors, such as lactose, but as shown now in this study also to
Patrick B. Konietzny, Hannelore Peters, Marc L. Hofer, Ulla I. M. Gerling‐Driessen, Robert P. de Vries, Thomas Peters, Laura Hartmann   +6 more
wiley   +1 more source

Genealogical typing of Neisseria meningitidis [PDF]

Microbiology, 2009
Despite the increasing popularity of multilocus sequence typing (MLST), the most appropriate method for characterizing bacterial variation and facilitating epidemiological investigations remains a matter of debate. Here, we propose that different typing schemes should be compared on the basis of their power to infer clonal relationships and investigate
Didelot, X, Urwin, R, Maiden, M, Falush, D   +3 more
openaire   +5 more sources

Intermittent Attractive Interactions Lead to Microphase Separation in Non-motile Active Matter [PDF]

, 2022
Non-motile active matter exhibits a wide range of non-equilibrium collective phenomena yet examples are crucially lacking in the literature. We present a microscopic model inspired by the bacteria {\it Neisseria Meningitidis} in which diffusive agents feel intermittent attractive forces.
arxiv   +1 more source

Cortactin: A universal host cytoskeletal target of Gram‐negative and Gram‐positive bacterial pathogens

Molecular Microbiology, Volume 118, Issue 6, Page 623-636, December 2022., 2022
In host‐pathogen interactions, actin‐cytoskeletal dynamics play a crucial role in successful adherence, invasion, and intracellular motility by many intruding microbes. To achieve this goal, bacterial pathogens target major host regulators, one of which is the key actin‐binding protein and class‐II actin nucleation‐promoting factor cortactin.
Irshad Sharafutdinov, Jakob Knorr, Klemens Rottner, Steffen Backert, Nicole Tegtmeyer   +4 more
wiley   +1 more source

Towards the Immunoproteome of Neisseria meningitidis [PDF]

PLoS ONE, 2009
Despite the introduction of conjugated polysaccharide vaccines for many of the Neisseria meningitidis serogroups, neisserial infections continue to cause septicaemia and meningitis across the world. This is in part due to the difficulties in developing a, cross-protective vaccine that is effective against all serogroups, including serogroup B ...
Mendum, TA, Newcombe, J, McNeilly, CL, McFadden, J   +3 more
openaire   +6 more sources

The prevalence of side-effects: Ciprofloxacin 500 mg single dose prophylaxis against Neisseria Meningitidis outbreak in Potchefstroom during July 2003

Health SA Gesondheid: Journal of Interdisciplinary Health Sciences, 2004
Potchefstroom experienced an outbreak of Neisseria meningitidis (N. meningitidis) during May-July 2003. An opportunity for obtaining valuable data arose when mass prophylactic treatment to approximately 28% of the Potchefstroom community was provided by ...
Michelle Viljoen, Martie S Lubbe, Rina CL Meyer   +2 more
doaj   +1 more source

Neisseria meningitidis Induced Fatal Waterhouse–Friderichsen Syndrome in a Patient Presenting With Disseminated Intravascular Coagulation and Multiple Organ Failure

Brain Sciences, 2020
Neisseria meningitidis-induced acute systemic meningococcal disease is an emergency and a fatal condition that has a high mortality rate. In patients with a fulminant infection, a maculopapular petechial eruption, purpura fulminans, or an ecchymotic ...
Meng-Yu Wu, Chien-Sheng Chen, Chih-Yi Tsay, Giou-Teng Yiang, Jian-Yu Ke, Po-Chen Lin   +5 more
doaj   +1 more source

Expression of phosphofructokinase in Neisseria meningitidis [PDF]

Microbiology, 2010
Neisseria meningitidisserogroup B is a pathogen that can infect diverse sites within the human host. According to theN. meningitidisgenomic information and experimental observations, glucose can be completely catabolized through the Entner–Doudoroff pathway and the pentose phosphate pathway. The Embden–Meyerhof–Parnas pathway is not functional, because
Baart, G.J.E., Langenhof, M., van de Waterbeemd, B., Hamstra, H.J., Zomer, B., van der Pol, L.A., Beuvery, E.C., Tramper, J., Martens, D.E.   +8 more
openaire   +4 more sources