Results 11 to 20 of about 1,042 (177)

Emerging Therapies in the Treatment of Prurigo Nodularis: Biological Therapy and Systematic Review of Literature [PDF]

Dermatology and Therapy
Introduction Prurigo nodularis (PN) is a chronic, intensely pruritic dermatosis characterized by hyperkeratotic nodules and a persistent itch–scratch cycle.
Gaetano Licata, Mariachiara Arisi, Caterina Mariarosaria Giorgio, Cesare Ariasi, Cesare Tomasi, Simone Soglia, Sara Mezzana, Benedetta Galli, Grazia Linda Artelli, Mariateresa Rossi, Cecilia Catapano   +10 more
doaj   +2 more sources

A Case of Erythema Multiforme Following the Administration of Nemolizumab. [PDF]

Cureus
Prurigo nodularis (PN) is a chronic inflammatory skin disorder characterized by intensely pruritic nodules. The pathogenesis of PN involves immune dysregulation, with a predominance of T helper (Th2)-type inflammation, including interleukin (IL)-4, IL-5, IL-13, and IL-31. Nemolizumab, an IL-31 receptor A inhibitor, was newly approved for PN in 2024. We
Mima Y, Ohtsuka T.
europepmc   +3 more sources

Efficacy and Safety of Nemolizumab for Treatment of Adult Atopic Dermatitis [PDF]

Journal of Investigational Allergy and Clinical Immunology, 2021
Freemantle, N, Piketty, C
core   +5 more sources

Mast cell–neuron axis as a core mechanism in chronic pruritus of atopic dermatitis: from mechanistic insights to therapeutic targets [PDF]

Frontiers in Immunology
Chronic pruritus is a defining and therapeutically challenging symptom of atopic dermatitis (AD). Recent advances highlight the mast cell–neuron axis as a central neuroimmune interface orchestrating bidirectional crosstalk between the immune and ...
Dongdong Li, Dongdong Li, Yusheng Han, Jingjing Zhou, Huasen Yang, Jing Chen, Hong Liang Tey, Hong Liang Tey, Hong Liang Tey, Timothy T. Y. Tan, Timothy T. Y. Tan   +10 more
doaj   +2 more sources

Dupilumab: an Additional Arrow in the Quiver for Prurigo Nodularis? Data From a Real-Life Setting [PDF]

Dermatology Practical & Conceptual
Introduction: Prurigo nodularis (PN) management remains a significant challenge due to its chronicity, treatment resistance, and scarcity of approved treatments and to its impact on patients' quality of life.
Roberta Di Caprio, Stefano Caccavale, Eugenia Veronica Di Brizzi, Caterina Giorgio, Aleksandra Stefaniak, Giuseppe Argenziano, Anna Balato   +6 more
doaj   +2 more sources

Nemolizumab-induced psoriasiform dermatitis. [PDF]

JAAD Case Rep
Absil G, Collins P, Colleye O, Dezfoulian B, Nikkels AF.   +4 more
europepmc   +2 more sources

Trastuzumab-associated prurigo nodularis successfully treated with nemolizumab: A case report [PDF]

JAAD Case Reports
Ryan Chen, BA, Michelle S. Lee, MD, Ashleigh Eberly Puleo, PA-C, Arshna Qureshi, MBBS, Alvaro C. Laga, MD, MMSc, Vinod E. Nambudiri, MD, MBA, MPH, EdM   +5 more
doaj   +2 more sources

Biologics and Small-Molecule Therapies in Netherton Syndrome: A Comprehensive Review. [PDF]

J Dermatol
Netherton syndrome (NS) is a rare congenital ichthyosis caused by loss-of-function mutations in the SPINK5 gene, leading to defective expression of the serine protease inhibitor LEKTI.
Morizane S, Mukai T, Sunagawa K, Hasui KI, Morita A, Nomura H, Ouchida M.   +6 more
europepmc   +3 more sources

Interplay of cytokines in the pathophysiology of atopic dermatitis: insights from Murin models and human [PDF]

Frontiers in Medicine
The pathogenesis of atopic dermatitis (AD) is understood to be crucially influenced by three main factors: dysregulation of the immune response, barrier dysfunction, and pruritus.
Yuto Yamamura, Chisa Nakashima, Atsushi Otsuka   +2 more
doaj   +3 more sources

New and Emerging Biologics and Jak Inhibitors for the Treatment of Prurigo Nodularis: A Narrative Review [PDF]

Medicina
Prurigo nodularis (PN) is a chronic dermatological condition characterized by intensely pruritic nodules resulting from repeated scratching. Its pathogenesis involves neuroimmune dysregulation, inflammatory cytokines, and neural proliferation ...
Matteo Bianco, Francesco D’Oria, Costanza Falcidia, Giulio Foggi, Elena Matteodo, Sara Di Giulio, Paola Facheris, Luciano Ibba, Chiara Perugini, Mario Valenti, Carlo Alberto Vignoli, Antonio Costanzo, Alessandra Narcisi, Luigi Gargiulo   +13 more
doaj   +2 more sources