Results 41 to 50 of about 1,042 (177)

Current and emerging biologics for the treatment of pediatric atopic dermatitis [PDF]

, 2020
Introduction: Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by erythematous lesions, pruritus, and a skin barrier defect.
Balogh, Esther A., Bell, Katheryn A., Feldman, Steven R., Ghamrawi, Rima, Strowd, Lindsay C.   +4 more
core   +1 more source

IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis. [PDF]

, 2023
Despite robust literature associating IL-31 with pruritic inflammatory skin diseases, its influence on cutaneous inflammation and the interplay between inflammatory and neurosensory pathways remain unmapped.
Ansel, Karl, Basbaum, Allan, Braz, Joao, Castellanos, Carlos, Caston, Jaela, Fassett, Marlys, Lazarevsky, Steven, Mar, Darryl, Munoz-Sandoval, Priscila, Roy, Suparna, Sadeghi, Mahsa, Salvatierra, Juan, Schroeder, Andrew, Shin, Jeoung-Sook, Yu, Xiaobing, Zhou, Connie   +15 more
core   +1 more source

Transcriptomic characterization of prurigo nodularis and the therapeutic response to nemolizumab [PDF]

Journal of Allergy and Clinical Immunology, 2022
Prurigo nodularis (PN) is a debilitating, difficult-to-treat, intensely pruritic, chronic inflammatory skin disease characterized by hyperkeratotic skin nodules. The pathogenesis of PN is not well understood but is believed to involve cross talk between sensory nerve fibers, immune cells, and the epidermis.
Lam C, Tsoi, Feriel, Hacini-Rachinel, Paul, Fogel, Francois, Rousseau, Xianying, Xing, Matthew T, Patrick, Allison C, Billi, Celine C, Berthier, J Michelle, Kahlenberg, Anne, Lazzari, Henning, Wiegmann, Sonja, Ständer, Christophe, Piketty, Valerie, Julia, Jayendra Kumar, Krishnaswamy, Johann E, Gudjonsson   +15 more
openaire   +2 more sources

Az atópiás dermatitis patomechanizmusa [PDF]

, 2018
L
Steuer-Hajdu, Krisztina, Szegedi, Andrea
core   +1 more source

Generalized prurigo nodularis after dermatomal herpes zoster: Resolution with nemolizumab. [PDF]

JAAD Case Rep
Fason C, Tyring S.
europepmc   +2 more sources

Dupilumab: A new paradigm for the treatment of allergic diseases [PDF]

, 2018
Moderate and severe forms of allergic diseases such as atopic dermatitis and asthma are a challenge for clinicians. In these conditions, which severely affect the quality of life of the patient and frequently have associated allergic comorbidities, the ...
Dávila, Ignacio, Sastre, Joaquín
core   +2 more sources

Characterization of the effects on pruritus by novel treatments for atopic dermatitis [PDF]

, 2021
Chronic pruritus is a common and debilitating symptom in patients with atopic dermatitis and contributes to impairment of quality of life. Effective treatment of pruritus should therefore be one of the main treatment goals in patients with atopic ...
Bonnekoh, Hanna, Butze, Monique, Metz, Martin   +2 more
core   +1 more source

Phase 3 Trial of Nemolizumab in Patients with Prurigo Nodularis

New England Journal of Medicine, 2023
Prurigo nodularis is a chronic, debilitating, and severely pruritic neuroimmunologic skin disease. Nemolizumab, an interleukin-31 receptor alpha antagonist, down-regulates key pathways in the pathogenesis of prurigo nodularis.In this phase 3, double-blind, multicenter, randomized trial, we assigned adults with moderate-to-severe prurigo nodularis to ...
Kwatra, Shawn G, Yosipovitch, Gil, Legat, Franz J, Reich, Adam, Paul, Carle, Simon, Dagmar, Naldi, Luigi, Lynde, Charles, De Bruin-Weller, Marjolein S, Nahm, Walter K, Sauder, Maxwell, Gharib, Rola, Barbarot, Sebastien, Szepietowski, Jacek C, Conrad, Curdin, Fleischer, Alan, Laquer, Vivian T, Misery, Laurent, Serra-Baldrich, Esther, Lapeere, Hilde, Ahmad, Faiz, Jabbar Lopez, Zarif K, Piketty, Christophe, Ständer, Sonja, Schuttelaar, Marielouise   +24 more
openaire   +5 more sources

Interleukin-31 Signaling Bridges the Gap Between Immune Cells, the Nervous System and Epithelial Tissues

Frontiers in Medicine, 2021
Pruritus represents one of the most common symptoms in dermatology and general medicine. Chronic pruritus severely impairs the quality of life of affected patients.
Jana Maria Nemmer, Marcus Kuchner, Angeliki Datsi, Angeliki Datsi, Péter Oláh, Péter Oláh, Valérie Julia, Ulrike Raap, Bernhard Homey   +8 more
doaj   +1 more source

Allergen sensitization stratifies IL-31 production by memory T cells in atopic dermatitis patients [PDF]

, 2023
Atopic dermatitis; Memory T cells; PruritusDermatitis atòpica; Cèl·lules T de memòria; PruritDermatitis atópica; Células T de memoria; PruritoBackground: The role of allergen sensitization in IL-31 production by T cells and specifically in the clinical ...
Bonfill Ortí, Montserrat, Curto-Barredo, Laia, Figueras, Ignasi, García Jiménez, Irene, Guilabert, Antonio, Sans De San Nicolàs, Lídia   +5 more
core   +5 more sources