Results 101 to 110 of about 4,626,170 (385)

Plasma DNMT1 Activity for Assessing Tumor Burden and Predicting Neoadjuvant Therapy Response in Breast Cancer

Advanced Science, EarlyView.
In this work, a detection method is presented for the activity of plasma DNA methyltransferase 1 (DNMT1), namely DNMT1 Identification by Variable Activity (DIVA). DIVA can detect plasma DNMT1 at levels as low as 10−7 U mL−1, also it successfully evaluated tumor burden and predicted the neoadjuvant therapy responses of breast cancer patients.
Yingran Wang, Guozhi Zhang, Zhizhao Zhang, Mengsi Zhang, Jiao Chen, Ke Wang, Lu Liu, Jing Bao, Ming Chen, Xiaowei Qi, Mingxuan Gao   +10 more
wiley   +1 more source

Concomitant CIS on TURBT does not impact oncological outcomes in patients treated with neoadjuvant or induction chemotherapy followed by radical cystectomy [PDF]

, 2018
© Springer-Verlag GmbH Germany, part of Springer Nature 2018Background: Cisplatin-based neoadjuvant chemotherapy (NAC) for muscle invasive bladder cancer improves all-cause and cancer specific survival.
A Takayanagi, A. J. Stephenson, A. S. Fairey, A. Thorpe, B. W. van Rhijn, BG Volkmer, C. E. Ercole, C. P. Dinney, CJ Weight, CP Dinney, CP Dinney, D Liu, D. A. Barocas, DC Chade, DE Thomas, E. Xylinas, E. Y. Yu, EM Allen Van, ER Plimack, ER Seiler Plimack, H Zargar, H Zargar, H. Zargar, HB Grossman, J. A. Seah, J. Aning, J. B. Shah, J. Griffin, J. L. Wright, J. M. Holzbeierlein, J. P. Noël, J. S. McGrath, J. S. Montgomery, JB Kukreja, L. M. Krabbe, L. S. Mertens, M. A. Dall’Era, M. C. Mir, M. S. Cookson, MA Knowles, N. E. Jacobsen, N. J. Campain, N. M. Gandhi, N. Vasdev, P. C. Black, P. E. Spiess, P. Grivas, R. Veeratterapillay, S Masood, S. Daneshmand, S. F. Shariat, S. Horenblas, S. North, S. S. Sridhar, T. J. Bivalacqua, T. M. Morgan, TJN Hermans, W Choi, W Choi, W. Kassouf, WP Parker, Y. Lotan   +61 more
core   +2 more sources

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer

Advanced Science, EarlyView.
This study presents an explainable multimodal AI model, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing), that combines whole‐slide histopathology with clinical data for accurate germline BRCA1/2 mutation prescreening. By integrating digital pathology and EHR phenotypes, MAIGCT enables cost‐effective, scalable hereditary breast ...
Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu   +23 more
wiley   +1 more source

Volume of breast tissue excised during breast-conserving surgery in patients undergoing preoperative systemic therapy [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2013
PURPOSE: We aimed to determine whether clinical examination could adequately ascertain the volume of tissue to be resected during breast-conserving surgery after neoadjuvant therapy.
Fernando Antonio Mourão Valejo, Daniel Guimarães Tiezzi, Larissa Raquel Mouro Mandarano, Christiani Bisinoto de Sousa, Jurandyr Moreira de Andrade   +4 more
doaj   +1 more source

Adipocytes Promote Cisplatin Resistance through Secreting A1BG and Regulating NAMPT/PARP1 Axis‐Mediated DNA Repair in Osteosarcoma

Advanced Science, EarlyView.
The proposed working model for how adipocytes participate in cisplatin resistance in osteosarcoma. The adipocytes secret A1BG and stabilize NAMPT, leading to increased NAD⁺ levels and subsequent increased PARP1‐mediated DNA repair, resulting in cisplatin resistance in osteosarcoma finally.
Yonghui Liang, Zhaohui Li, Lina Tang, Zhen Pan, Xiang Fei, Chen Tan, Aina He, Qingcheng Yang, Dongdong Cheng   +8 more
wiley   +1 more source

Long‐term prognosis is associated with residual disease after neoadjuvant systemic therapy but not with initial nodal status

BJS (British Journal of Surgery), EarlyView., 2020
This long‐term follow‐up study determined survival rates in a Swedish national cohort of 417 patients with breast cancer who all had neoadjuvant systemic therapy (NAST). Sentinel lymph node biopsy (SLNB) was performed before NAST in clinically node‐negative and after NAST in clinically node‐positive patients.
L. Zetterlund, F. Celebioglu, T. Hatschek, J. Frisell, J. de Boniface   +4 more
wiley   +1 more source

NEOADJUVANT ENDOCRINE THERAPY FOR PATIENTS WITH ESTROGEN-RECEPTOR-POSITIVE BREAST CANCER

Сибирский онкологический журнал, 2018
More than 70 % of patients with breast cancer have estrogen-receptor-positive tumors (ER+) and are considered hormone- sensitive. That is why a vast majority of patients with early operable  tumors receive adjuvant endocrine therapy.
V. F. Semiglazov, V. V. Semiglazov, G. A. Dashyan, P. V. Krivorotko, V. G. Ivanov, E. K. Zhiltsova, R. M. Paltuev, L. M. Bershtein, T. Yu. Semiglazova, S. S. Yerechshenko, V. V. Klimenko, V. S. Apollonova, A. V. Komyahov, A. A. Bessonov   +13 more
doaj   +1 more source

Cryogel‐Based Dendritic Cell Immunotherapy for Post‐Surgical Breast Cancer Treatment

Advanced Science, EarlyView.
A multifunctional GelMA cryogel enables dendritic cell immunotherapy that synergizes with doxorubicin and PD‐1 blockade, driving robust post‐surgical T‐cell immunity and suppressing TNBC recurrence. Abstract Triple‐negative breast cancer (TNBC) is an aggressive malignancy with high mortality and limited treatment options.
Lam‐Duc‐Huy Nguyen, Sheng‐Liang Cheng, Yu‐Ting Yen, Hsin‐Mei Lee, Te‐Haw Wu, Jane Wang, Shu‐Yi Lin, Yunching Chen   +7 more
wiley   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source

Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

JAMA Oncology, 2018
Importance Treatment of locally advanced rectal (LARC) cancer involves chemoradiation, surgery, and chemotherapy. The concept of total neoadjuvant therapy (TNT), in which chemoradiation and chemotherapy are administered prior to surgery, has been ...
A. Cercek, C. Roxburgh, C. Roxburgh, P. Strombom, J. Smith, L. Temple, G. Nash, J. Guillem, P. Paty, R. Yaeger, Z. Stadler, K. Seier, M. Gonen, N. Segal, D. Reidy, A. Varghese, J. Shia, E. Vakiani, A. Wu, C. Crane, M. Gollub, J. García-Aguilar, L. Saltz, M. Weiser   +23 more
semanticscholar   +1 more source