Results 121 to 130 of about 2,703,409 (308)

Neoadjuvant transarterial chemoembolization with tyrosine kinase and immune checkpoint inhibitors improves survival from resectable hepatocellular carcinoma in a multicenter, retrospective study (GUIDANCE002)

Communications Medicine
Background Hepatectomy is considered advisable for some patients with intermediate or advanced hepatocellular carcinoma (HCC). The efficacy and safety of neoadjuvant transarterial chemoembolization with tyrosine kinase and immune checkpoint inhibitors ...
Da-Long Yang, Chuang Qin, Ning Peng, Shao-Ping Liu, Ya-Qun Yu, Jun-Liang Nong, Fan-Jian Zeng, Ze Su, Yong-Yu Yang, Fu-Quan Yang, Mian-Jing Li, Ming-Song Wu, Xue-Yao Wang, Yong-Rong Liang, Fu-Xin Li, Shu-Chang Chen, Yong-Cheng Lai, Qing-Qing Pang, Teng-Meng Zhong, Yi-He Yan, Ying-Yu Zhang, Lin Ye, Xiao-Feng Dong, Wen-Feng Li, Jie Liu, Hong-Bing Yao, Pei-Sheng Wu, Xian-Shuang Mao, Jun-Jie Ou, Yao-Zhi Chen, Guo-Dong Wang, Kang Chen, Zhu-Jian Deng, Jia-Yong Su, Guo-Gao Qiu, Zhi-Dong Liu, Jin-Min Wang, Yi Zhang, Xiu-Mei Liang, Bang-De Xiang, Liang Ma, Jian-Hong Zhong, On behalf of the GUIDANCE investigators   +42 more
doaj   +1 more source

NCLX Inhibition plus Ca2+ Delivery Potentiates Electroporation and Antitumor Immunity in Pancreatic Ductal Adenocarcinoma

Advanced Science, EarlyView.
Electroporation combined with NCLX inhibition and Ca2+ delivery induces mitochondrial Ca2+ overload in PDAC cells, triggering pyroptosis, DAMP release, and antitumor immune activation. Simultaneously, suppression of tumor‐derived SPP1 weakens SPP1–CD44 signaling and remodels macrophages toward an antitumor phenotype, thereby enhancing CD8+ T‐cell ...
Chuanbing Zhao, Long He, Yu Lu, Zanglong Deng, Hongzhen Wei, Yunpeng Zhang, Ming Yang, Tao Yin   +7 more
wiley   +1 more source

ZMIZ2–DUX4–LGR5 Signaling Axis Maintains Stemness Properties and Facilitates Docetaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study identifies ZMIZ2 as a therapeutic target for docetaxel‐resistant triple‐negative breast cancer, sustaining cancer stemness‐associated properties and docetaxel resistance. ZMIZ2 upregulation enhances DUX4‐mediated LGR5 activation through the SWI/SNF components BRG1 and BAF57.
Xueting Gan, Shulei Sun, Ran Hu, Yuheng Feng, Xinhao Wu, Fangqi Liu, Xuyong Lin, Xiupeng Zhang, Xuezhu Rong, Qiang Han   +9 more
wiley   +1 more source

The Characteristics of Tumor Microenvironment by the Single Cell Profile in Endometrial Cancer of no Specific Molecular Profile (NSMP) Subtype

Advanced Science, EarlyView.
A subset of tumor‐associated macrophages (TAMs) characterized by SPP1 expression is discovered, which may remodel the tumor microenvironment by potentially promoting CD4+ T cell stress and maintaining epithelial cell stemness through SPP1‐CD44, thereby potentially contributing to the proliferation and migration of tumor cells, which has been verified ...
Xinhui Yuan, Zhengyao Zhai, Chuyu Jing, Wei Zhang, Wenjuan Tian, Yulan Ren   +5 more
wiley   +1 more source

Noninvasive Detection and Subtyping of Esophageal Cancer by Circulating Cell‐Free mtDNA Fragmentomics: A Multi‐Center Validation Study

Advanced Science, EarlyView.
Circulating cell‐free mitochondrial DNA provides a robust, noninvasive platform for early detection and histological subtyping of esophageal cancer. This large multi‐center study validates consistently high accuracy across ethnically and geographically diverse cohorts, demonstrating strong potential to transform clinical management. ABSTRACT Esophageal
Yue Liu, Wenying Yang, Yu Li, Siyuan Wang, Xiang Li, Fan Peng, Miao Dang, Huanqin Zhang, Huanmin Jiao, Yuqing Yang, Zhaoquan Su, Xiumin Ma, Zhiyun Gong, Renquan Lu, Jinliang Xing, Yang Liu   +15 more
wiley   +1 more source

Late Local Recurrence after Neoadjuvant Therapy and Radical Resection for Locally Advanced Rectal Cancer

Neoadjuvant radiochemotherapy (RCT) and lately total neoadjuvant therapy (TNT) improved local recurrence rates of rectal cancer significantly compared to total mesorectal excision (TME) alone. Yet the occurrence and impact of late local recurrences after
Marina Münch, Wolfgang Steurer, Hans Jürgen Schlitt, Adrian Salega, Dina Mönch, Klaus-Peter Thon, Jana Koch, Marc-Hendrik Dahlke, Tobias Leibold, Philipp Renner, Annika Maaß, Koch, Jana, Maaß, Annika, Mönch, Dina   +13 more
core   +1 more source

An Explainable Multimodal Deep‐Learning Model Using Histopathological Image and Clinical Information for Prognosis Prediction in Colorectal Cancer: A Multi‐Center Cohort Study

Advanced Science, EarlyView.
This study develops a multimodal deep‐learning model that integrates clinical variables and histopathological images to predict survival outcomes in colorectal cancer. The multimodal model effectively stratifies patients into low‐ and high‐risk groups, demonstrating superior accuracy and generalizability across multiple independent cohorts.
Zhihan Jiang, Xiangchao Shi, Chenghan Su, Yao Ma, Rui Li, Menglei Chen, Jianxin Cui, Nicholas Hawkins, Robyn Ward, Xiangzhi Bai, Jitendra Jonnagaddala, Wei Fu, Xin Zhou   +12 more
wiley   +1 more source

Evaluation of neoadjuvant therapy effectiveness in rectal cancer

, 2020
Rektum Kanserinde Neoadjuvan Tedavi Etkinliğinin DeğerlendirilmesiEvaluation of Neoadjuvant Therapy Effectiveness in Rectal ...
Alıyev, Elba
core  

The emergence of neoadjuvant therapy in advanced melanoma

, 2019
The discovery of immunotherapy and targeted therapy has introduced new and effective treatment options for advanced melanoma, providing therapeutic options where none existed before.
Zeynep Eroglu, Jonathan S Zager, Dennis A Kirichenko, James Sun   +3 more
core   +1 more source

Amcinonide Exhibits Antitumor Effects in Radioresistant Colorectal Cancer Through the circRNF10/miR‐296‐5p/Snail Axis

Advanced Science, EarlyView.
Amcinonide (AMC), the FDA‐approved corticosteroid, was identified as a repurposed agent for radiation‐resistant colorectal cancer. AMC suppresses radiation‐induced epithelial–mesenchymal transition, migration, and invasion via the circRNF10/miR‐296‐5p/Snail axis.
Hyun Jeong Seok, Dong Hyeon Lee, Junhye Kwon, Ui Sup Shin, In Hwa Bae   +4 more
wiley   +1 more source