Results 111 to 120 of about 4,593,278 (410)

Volume of breast tissue excised during breast-conserving surgery in patients undergoing preoperative systemic therapy [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2013
PURPOSE: We aimed to determine whether clinical examination could adequately ascertain the volume of tissue to be resected during breast-conserving surgery after neoadjuvant therapy.
Fernando Antonio Mourão Valejo, Daniel Guimarães Tiezzi, Larissa Raquel Mouro Mandarano, Christiani Bisinoto de Sousa, Jurandyr Moreira de Andrade   +4 more
doaj   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Health‐related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population‐based cohort study

BJS (British Journal of Surgery), EarlyView., 2020
All patients operated for oesophageal cancer in Sweden from 2013 to April 2018 were identified, and 246 patients were recruited to this population‐based nationwide Swedish study. The results show that longitudinal health‐related quality of life after minimally invasive oesophagectomy was similar to that of the open surgical approach.
F. Klevebro, J. H. Kauppila, S. Markar, A. Johar, P. Lagergren   +4 more
wiley   +1 more source

F-18-FDG and C-11-choline positron emission tomography in human esophago-gastric cancer : prediction of response to therapy [PDF]

, 2010
Peer reviewedPublisher ...
Hammonds, Solveig, McAteer, Dympna, Nicolson, Marianne, Park, Kenneth, Schweiger, Lutz, Sheehan, Margaret, Smith, Timothy, Suttie, Stuart, Welch, Andrew   +8 more
core   +1 more source

Functional Blockade of E-Selectin in Tumor-Associated Vessels Enhances Anti-Tumor Effect of Doxorubicin in Breast Cancer [PDF]

, 2020
Chemotherapy is a mainstay of treatment for solid tumors. However, little is known about how therapy-induced immune cell infiltration may affect therapy response.
Chervoneva, Inna, Davis, Rachel, Gorenstein, David G, Hasan, Nafis, Hills, Natalie, Ichimura, Norihisa, Kameyama, Hiroyasu, Kondo, Yuji, Leslie, Macall, Lokesh, Ganesh L R, Morita, Yoshihiro, Rui, Hallgeir, Tanaka, Takemi, Volk, David E, Zhang, Roy   +14 more
core   +3 more sources

Neoadjuvant Chemotherapy With Cisplatin Up‐Regulates GSDMD to Enhance Oral Squamous Cell Carcinoma Metastasis Through MMP14‐Mediated EMT Activation

Advanced Science, EarlyView.
Oral squamous cell carcinoma cells exhibit upregulated expression of GSDMD upon exposure to low‐dose cisplatin chemotherapy, which subsequently interacts with MMP14 through its N‐terminal domain, activating the epithelial‒mesenchymal transition (EMT) process and promoting the lymph node metastasis of oral squamous cell carcinoma.
Zixian Huang, Qiming Jiang, Qianyu Zhang, Nan Lu, Xi Rui, Rui Chen, Yan Wang, Yuepeng Wang, Xiaoding Xu, Zhiquan Huang   +9 more
wiley   +1 more source

The E2F Pathway Score as a Predictive Biomarker of Response to Neoadjuvant Therapy in ER+/HER2− Breast Cancer

Cells, 2020
E2F transcription factors play critical roles in the cell cycle. Therefore, their activity is expected to reflect tumor aggressiveness and responsiveness to therapy.
M. Oshi, Hideo Takahashi, Y. Tokumaru, Li Yan, O. Rashid, M. Nagahashi, R. Matsuyama, I. Endo, K. Takabe   +8 more
semanticscholar   +1 more source

Concomitant CIS on TURBT does not impact oncological outcomes in patients treated with neoadjuvant or induction chemotherapy followed by radical cystectomy [PDF]

, 2018
© Springer-Verlag GmbH Germany, part of Springer Nature 2018Background: Cisplatin-based neoadjuvant chemotherapy (NAC) for muscle invasive bladder cancer improves all-cause and cancer specific survival.
A Takayanagi, A. J. Stephenson, A. S. Fairey, A. Thorpe, B. W. van Rhijn, BG Volkmer, C. E. Ercole, C. P. Dinney, CJ Weight, CP Dinney, CP Dinney, D Liu, D. A. Barocas, DC Chade, DE Thomas, E. Xylinas, E. Y. Yu, EM Allen Van, ER Plimack, ER Seiler Plimack, H Zargar, H Zargar, H. Zargar, HB Grossman, J. A. Seah, J. Aning, J. B. Shah, J. Griffin, J. L. Wright, J. M. Holzbeierlein, J. P. Noël, J. S. McGrath, J. S. Montgomery, JB Kukreja, L. M. Krabbe, L. S. Mertens, M. A. Dall’Era, M. C. Mir, M. S. Cookson, MA Knowles, N. E. Jacobsen, N. J. Campain, N. M. Gandhi, N. Vasdev, P. C. Black, P. E. Spiess, P. Grivas, R. Veeratterapillay, S Masood, S. Daneshmand, S. F. Shariat, S. Horenblas, S. North, S. S. Sridhar, T. J. Bivalacqua, T. M. Morgan, TJN Hermans, W Choi, W Choi, W. Kassouf, WP Parker, Y. Lotan   +61 more
core   +1 more source

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer

Advanced Science, EarlyView.
This study presents an explainable multimodal AI model, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing), that combines whole‐slide histopathology with clinical data for accurate germline BRCA1/2 mutation prescreening. By integrating digital pathology and EHR phenotypes, MAIGCT enables cost‐effective, scalable hereditary breast ...
Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu   +23 more
wiley   +1 more source

Adoption of Total Neoadjuvant Therapy for Locally Advanced Rectal Cancer

JAMA Oncology, 2018
Importance Treatment of locally advanced rectal (LARC) cancer involves chemoradiation, surgery, and chemotherapy. The concept of total neoadjuvant therapy (TNT), in which chemoradiation and chemotherapy are administered prior to surgery, has been ...
A. Cercek, C. Roxburgh, C. Roxburgh, P. Strombom, J. Smith, L. Temple, G. Nash, J. Guillem, P. Paty, R. Yaeger, Z. Stadler, K. Seier, M. Gonen, N. Segal, D. Reidy, A. Varghese, J. Shia, E. Vakiani, A. Wu, C. Crane, M. Gollub, J. García-Aguilar, L. Saltz, M. Weiser   +23 more
semanticscholar   +1 more source