Results 111 to 120 of about 5,297,540 (313)

Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy

Journal of Clinical Oncology, 2022
J. García-Aguilar, S. Patil, M. Gollub, Jin K. Kim, J. Yuval, Hannah M Thompson, F. Verheij, D. Omer, Meghan E. Lee, R. Dunne, J. Marcet, P. Cataldo, B. Polite, Daniel O. Herzig, D. Liska, S. Oommen, C. Friel, C. Ternent, A. Coveler, S. Hunt, A. Gregory, M. Varma, B. Bello, J. Carmichael, J. Krauss, A. Gleisner, P. Paty, M. Weiser, G. Nash, E. Pappou, José G. Guillem, L. Temple, I. Wei, M. Widmar, Sabrina T. Lin, N. Segal, A. Cercek, R. Yaeger, J. Smith, K. Goodman, A. Wu, L. Saltz   +41 more
semanticscholar   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

High-efficacy targeting of colon-cancer liver metastasis with Salmonella typhimurium A1-R via intra-portal-vein injection in orthotopic nude-mouse models. [PDF]

, 2016
Liver metastasis is the main cause of colon cancer-related death and is a recalcitrant disease. We report here the efficacy and safety of intra-portal-vein (iPV) targeting of Salmonella typhimurium A1-R on colon cancer liver metastasis in a nude-mouse ...
Bouvet, Michael, Clary, Bryan M, Hiroshima, Yukihiko, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Murakami, Takashi, Suetsugu, Atsushi, Unno, Michiaki, Zhang, Yong, Zhao, Ming   +11 more
core   +3 more sources

Early Radiation Therapy Response Assessment Using Multi‐Scale Photoacoustic Imaging

Advanced Science, EarlyView.
Tomographic and mesoscopic photoacoustics capture intratumoural features of radioresistance and response. ABSTRACT There is a critical unmet clinical need to identify biomarkers that predict and detect radiation therapy (RT) response in cancer. Using the unique capabilities of multi‐scale photoacoustic imaging (PAI) to depict tumor oxygenation and ...
Thierry L. Lefebvre, Mariam‐Eleni Oraiopoulou, Ellie V. Bunce, Thomas R. Else, Lorna C. Wright, Monika A. Golinska, Lina Hacker, Cara Brodie, Steven Kupczak, Yi Cheng, Lisa Young, Paul W. Sweeney, Sarah E. Bohndiek   +12 more
wiley   +1 more source

Variability in the reported management of pulmonary metastases in osteosarcoma. [PDF]

, 2015
Nearly 20% of patients with newly diagnosed osteosarcoma have detectable metastases at diagnosis; the majority of which occur in the lungs. There are no established recommendations for the timing and modality of metastasectomy.
Bhattasali, Onita, Geller, David, Gill, Jonathan, Gorlick, Richard, Randall, R Lor, Roth, Michael, Vo, Andrea T   +6 more
core  

Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers [PDF]

, 2013
Introduction: We examined if a combination of proliferation markers and estrogen receptor (ER) activity could predict early versus late relapses in ER-positive breast cancer and inform the choice and length of adjuvant endocrine therapy.
Achim Rody, AJ Minn, Angelica Fasolo, B Haibe-Kains, B Thurlimann, Benjamin Haibe-Kains, C Bellera, C Davies, C Desmedt, C Kim, C Sotiriou, Catherine M Kelly, Christos Sotiriou, CJ van de Velde, D Sgroi, E Amir, G Bianchini, G Bianchini, G Tang, Giampaolo Bianchini, Gianluca Del Conte, H Jin, I Jatoi, JS Parker, KR Hess, KS Albain, Lajos Pusztai, Libero Santarpia, Luca Gianni, M Dowsett, M Filipits, M Schmidt, Marcus Schmidt, Milvia Zambetti, MJ Ellis, MJ van de Vijver, MM Regan, P Dubsky, R Simon, S Loi, S Loi, S Paik, Sven Becker, Takayuki Iwamoto, Thomas Karn, TO Nielsen, Uwe Holtrich, Volkmar Müller, W Fraser Symmans, WF Symmans, WR Miller, Y Wang, Y Zhang, Yuan Qi   +53 more
core   +1 more source

Cancer‐Associated Fibroblasts Functions as Multifunctional Architects of the Tumor Stroma and Represent Emerging Therapeutic Vulnerabilities

Advanced Science, EarlyView.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are the predominant stromal components within the tumor microenvironment (TME), playing multifaceted roles in cancer progression through dynamic interactions with neoplastic and immune cells. Emerging evidence has revealed remarkable heterogeneity and plasticity of CAFs, which originate from diverse ...
Rujiao Liu, Lili Su, Shuiping Gao, Wenting Liu, Hongxia Wang   +4 more
wiley   +1 more source

Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer. [PDF]

, 2014
BackgroundSipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood.
Amling, Christopher L, Carroll, Peter, Chan, Stephen, Corman, John, Fong, Lawrence, Frohlich, Mark W, Lewis, Jera, Sheikh, Nadeem A, Simko, Jeffrey, Sims, Robert B, Small, Eric J, Stephenson, Robert A, Weinberg, Vivian   +12 more
core   +2 more sources

Comparison of the safety and efficacy of different neoadjuvant therapy cycles for locally advanced gastric cancer: a retrospective propensity score-matched cohort study

World Journal of Surgical Oncology
Background For locally advanced gastric cancer (LAGC), neoadjuvant therapy prior to radical gastrectomy has been widely used. However, the treatment cycle and factors affecting the efficacy of neoadjuvant therapy are still unclear.
Zhihua Ren, Juan Tang, Haolin Xu, Shiyang Hou, Yiwen Wang, Zhenyu Hou, Hui Qu   +6 more
doaj   +1 more source

Comparison of neoadjuvant treatment and surgery first for resectable or borderline resectable pancreatic carcinoma: A systematic review and network meta-analysis of randomized controlled trials.

PLoS ONE
BackgroundCurrent treatment recommendations for resectable or borderline pancreatic carcinoma support upfront surgery and adjuvant therapy. However, neoadjuvant therapy (NT) seems to increase prognosis of pancreatic carcinoma and come to everyone's ...
Lu Huan, Fucai Yu, Ding Cao, Hantao Zhou, Maoling Qin, Yang Cao   +5 more
doaj   +1 more source