Results 151 to 160 of about 2,703,409 (308)

The Geriatric Nutritional Risk Index Predicts Short‐ and Long‐Term Outcomes in the Oldest‐Old With Colorectal Cancer: A Multi‐Institutional Analysis of 225 Nonagenarians

Annals of Gastroenterological Surgery, EarlyView.
This multi‐institutional study evaluated the Geriatric Nutritional Risk Index (GNRI) in 225 nonagenarians undergoing surgical resection for colorectal cancer. A lower preoperative GNRI was independently associated with a longer hospital stay and poorer overall survival, even after adjustment for confounders using inverse‐probability‐of‐treatment ...
Toshiaki Toshima, Fuminori Teraishi, Satoe Takanaga, Toshiharu Mitsuhashi, Ryo Inada, Tsuyoshi Ohtani, Ryosuke Yoshida, Naoto Hori, Kaoru Shigemitsu, Sumiharu Yamamoto, Tetsushi Kubota, Yuka Okano, Tetsuji Nobuhisa, Fumitaka Taniguchi, Wataru Ishikawa, Ryohei Shoji, Tatsuo Matsuda, Tatsuo Umeoka, Toshiyoshi Fujiwara, The Setouchi Colorectal Neoplasm Registration Study Group Collaborators   +19 more
wiley   +1 more source

Controversies and Perspectives in the Current Management of Patients with Locally Advanced Rectal Cancer—A Systematic Review

Life
Traditionally, the therapeutic approach to rectal cancer has involved neoadjuvant chemoradiotherapy followed by surgical resection, and, in some cases, adjuvant chemotherapy.
Roxana Elena Stefan, Rodica Daniela Birla, Mircea Gheorghe, Daniela Elena Dinu, Petre Angel Hoara, Diana Ciuc, Valeriu-Gabi Dinca, Silviu Constantinoiu   +7 more
doaj   +1 more source

Exploring Symptom Domains of Postoperative Bowel Dysfunction by Integrating LARS and Wexner Scores: A Longitudinal Factor‐Analytic Study

Annals of Gastroenterological Surgery, EarlyView.
Item‐level factor analysis of the LARS and Wexner scores in 320 patients undergoing sphincter‐preserving rectal resection identified three distinct symptom domains: incontinence, urgency/clustering, and gas control. These domains had different clinical determinants: radiotherapy was associated with greater severity of both incontinence and urgency ...
Yoshiko Matsumoto, Issei Takeshita, Keiichi Shiokawa, Kurumi Sahara, Taro Munechika, Ken Nagata, Hideki Nagano, Hiroyuki Takahashi, Suguru Hasegawa   +8 more
wiley   +1 more source

Current Status of Neoadjuvant Treatment Before Surgery in High-Risk Localized Prostate Cancer

Localized high-risk (HR) prostate cancer (PCa) is a heterogeneous disease whose likelihood of a biochemical recurrence, metastatic progression and cancer-related mortality after initial treatment is higher when compared with patients with low (LR) or ...
Luis Enrique Ortega Polledo, Noelia Sanmamed Salgado, Dmitry Enikeev, Beatriz Gutiérrez Hidalgo, María Jesús Marugán Álvarez, Jesús Moreno Sierra, Bhaskar K. Somani, María Isabel Galante Romo, Javier Martín Monterrubio, Juan Gómez Rivas, Javier Puente Vázquez, Irene De La Parra Sánchez   +11 more
core   +1 more source

Clinical Implementation and Perioperative Outcomes of Robot‐Assisted Pelvic Exenteration for Primary Rectal Cancer: A Multicenter Japanese Experience

Annals of Gastroenterological Surgery, EarlyView.
Robot‐assisted pelvic exenteration (RPE) was performed with acceptable perioperative outcomes in selected patients with primary rectal cancer. It may serve as a complementary approach at institutions with sufficient experience in PE, whereas open surgery remains essential for extensive or technically demanding disease.
Shoma Yamamoto, Hiroyasu Kagawa, Yusuke Yatabe, Yusuke Kinugasa   +3 more
wiley   +1 more source

Short‐Term Outcomes of Transanal Total Mesorectal Excision for Rectal Cancer: A Multicenter Propensity Score‐Matched Analysis Comparing Patients With and Without Preoperative Neoadjuvant Therapy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim To evaluate the association between preoperative neoadjuvant therapy and short‐term outcomes of transanal total mesorectal excision for rectal cancer. Methods We retrospectively analyzed patients who underwent transanal total mesorectal excision at 26 Japanese institutions between 2012 and 2019.
Takafumi Shima, Hiroki Hamamoto, Takeru Matsuda, Ichiro Takemasa, Keitaro Tanaka, Toshiki Mukai, Jun Watanabe, Sang‐Woong Lee, Seiichiro Yamamoto, Takeshi Naitoh, Ta‐Ta‐Mi Study Group Collaborators from the Japan Society of Laparoscopic Colorectal Surgery, Akihiro Kondo, Akinobu Taketomi, Akiyoshi Kanazawa, Atsushi Ogura, Chikayoshi Tani, Gunpei Yoshimatsu, Hideki Endo, Hideya Kashihara, Hirokazu Suwa, Junichiro Kawamura, Kay Uehara, Kei Kimura, Keiichi Okano, Keiichiro Okuyama, Kenji Okita, Kiyoshi Maeda, Kohei Shigeta, Koji Okabayashi, Koya Hida, Masafumi Inomata, Masahiko Watanabe, Masaji Tani, Masataka Ikeda, Masatsune Shibutani, Masayoshi Iwamoto, Masayuki Ishii, Nobuki Ichikawa, Shigenori Honma, Shinichiro Mori, Shiro Terai, Suguru Hasegawa, Takeshi Okabayashi, Takuya Tokunaga, Tatsunari Fukuoka, Tatsuya Manabe, Tatsuya Shonaka, Tomonori Akagi, Toru Kuramoto, Toru Miyake, Toshikatsu Nitta, Toshiki Mukai, Yoshihito Ide, Yosuke Fukunaga, Yuki Murata, Yukinari Tokoro, Yukitoshi Todate, Yusaku Shogen   +57 more
wiley   +1 more source

Targeting treatment resistance: unveiling the potential of RNA methylation regulators and TG-101,209 in pan-cancer neoadjuvant therapy

Journal of Experimental & Clinical Cancer Research
Background Tumor recurrence and mortality rates remain challenging in cancer patients despite comprehensive treatment. Neoadjuvant chemotherapy and immunotherapy aim to eliminate residual tumor cells, reducing the risk of recurrence.
Yaoyao Zhou, Ziyun Liu, Cheng Gong, Jie Zhang, Jing Zhao, Xia Zhang, Xiangyu Liu, Bin Li, Rui Li, Zhenyu Shi, Yongjie Xie, Li Bao   +11 more
doaj   +1 more source

Prognostic Significance and Clinical Robustness of the HALP Score in Super‐Elderly Patients Undergoing Curative Gastrectomy for Gastric Cancer: A Multicenter Retrospective Cohort Study

Annals of Gastroenterological Surgery, EarlyView.
In this multicenter study of 507 patients aged ≥ 80 years who underwent curative gastrectomy for gastric cancer, a low preoperative HALP score was independently associated with poor overall survival. This association remained consistent across multiple complementary analyses, and low HALP was also associated with both cancer‐specific and other‐cause ...
Hiroyuki Inoue, Takeshi Kubota, Toshiyuki Kosuga, Keiji Nishibeppu, Shutaro Sumiyoshi, Junichi Hamada, Kazuya Takabatake, Keita Katsurahara, Yosuke Ariyoshi, Koji Miyagawa, Sojin Sai, Yoshiki Itokawa, Tomoya Hatakeyama, Fumiaki Ochi, Hirotaka Konishi, Hitoshi Fujiwara, Atsushi Shiozaki   +16 more
wiley   +1 more source

Local Recurrence and Oncological Outcomes After Transanal Total Mesorectal Excision With Intersphincteric Resection for Lower Rectal Cancer: A Nationwide Multicenter Cohort Study (Ta‐Ta‐Mi Study)

Annals of Gastroenterological Surgery, EarlyView.
The 3‐year local recurrence (LR), recurrence‐free survival, and overall survival rates were 7.3%, 79.5%, and 98.1%, respectively. Multivariable analysis identified circumferential resection margin (CRM)/radial margin (RM) positivity as an independent risk factor for LR.
Kan Tanabe, Shinichiro Mori, Kenji Baba, Takeru Matsuda, Ichiro Takemasa, Koji Okabayashi, Chikayoshi Tani, Tatsuya Manabe, Yoshihiro Kakeji, Takao Ohtsuka, Seiichiro Yamamoto, Takeshi Naitoh, Ta‐Ta‐Mi Study Group Collaborative of the Japan Society of Laparoscopic Colorectal Surgery   +12 more
wiley   +1 more source

Total Neoadjuvant Therapy in Localized Pancreatic Cancer: Is More Better?

Pancreatic ductal adenocarcinoma (PDAC) poses a significant challenge in oncology due to its advanced stage upon diagnosis and limited treatment options.
Benjelloun El Ghali, Julie Navez, Jean-Luc Van Laethem, Rita Saúde-Conde, Christelle Bouchart   +4 more
core   +1 more source