Results 141 to 150 of about 25,910 (264)

Hyperthermia‐induced cytotoxicity and modulation of PD‐L1 and MHC‐I expression in human non‐small cell lung cancer cell lines

Experimental Physiology, EarlyView.
Abstract Hyperthermia has recently been applied to treat human non‐small cell lung cancer (NSCLC). However, the mechanisms underlying cytotoxic sensitivity of NSCLC cells to hyperthermia are not fully understood. In this study, five NSCLC cell lines with different epidermal growth factor receptor (EGFR), Kirsten rat sarcoma and tumor protein p53 ...
Yun‐Chieh Tu, Wei‐Chen Yeh, Yi‐Wei Fang, Ko‐Hsuan Lo, Lei‐Ni Liang, Xu‐Chen Liu, Chia‐Chi Tsai, Chih‐Cheng Cheng, Meng‐Chieh Lin, Hsin‐Hsien Yu, Bor‐Chyuan Su   +10 more
wiley   +1 more source

Spatial colocalization of neoantigen-expressing tumor cells and cognate T cells in cancer 2309241

Introduction Tumor neoantigens have emerged as promising candidates for personalized immunotherapies, however, confirming their presentation and immunogenicity remains challenging due to low neoantigen expression and limited detection
Giovanni Marrero, Shuqiang Li, Vipin Kumar, Jack Ghannam, Alexander Afeyan, Fei Chen, Lucas Pomerance, Camila Robles-Oteiza, Andrew Russell, Nir Hacohen, Adi Nagler, Catherine Wu, McKayla Van-Orden, David Reardon, Charles Yoon, David Braun, Toni Choueiri, MacLean Sellars, Amit Sud, Qiyu Gong, Andrea Sonnenholzner, Patrick Ott, Wesley Lu, Jackson Weir, Kenneth Livak, Giacomo Oliveira   +25 more
core   +1 more source

Nontumor‐Specific mRNA Sensitization of Cold Tumors to Immune Checkpoint Blockade: Evidence, Bias, and Requirements for Translation

Advanced Oncology, Volume 1, Issue 1, December 2026.
Messenger RNA constructs encoding nontumor antigens are proposed to sensitize cold tumors to checkpoint blockade. Observational survival estimates favor vaccination but are heterogeneous, and bias‐focused analyses find no significant difference once time‐zero is aligned. Epitope spreading remains undemonstrated in humans. This review separates what the
Sarfaraz K. Niazi
wiley   +1 more source

Teleport‐stabilised quantum‐walk transport for robust neoantigen ranking in near‐tie regimes: A reproducible colorectal benchmark

Clinical and Translational Discovery, Volume 6, Issue 6, December 2026.
Teleport‐stabilised quantum‐walk transport for robust neoantigen ranking in near‐tie regimes. The analysis proceeds from patient‐conditioned candidate definition to weighted evidence‐graph construction, quotient‐basin compression, continuous‐time quantum‐walk (CTQW)/discrete‐time quantum walk (DTQW) transport, teleport‐consensus stabilisation, ABHA ...
Ioannis Grigoriadis
wiley   +1 more source

TAMAVAQ/Q‐TAMAVAQ: Fubini–study CTQW graph transport and constrained margin‐based ranking for neoantigen candidate prioritization in lower‐grade glioma and glioblastoma

Clinical and Translational Discovery, Volume 6, Issue 6, December 2026.
Abstract Background Personalized neoantigen vaccine design for glioma requires the integration of mutation‐derived peptide evidence, molecular properties, HLA coverage and finite manufacturing capacity. TAMAVAQ/Q‐TAMAVAQ combines quantum‐geometric descriptor representation with graph transport and auditable peptide‐panel assembly.
Ioannis Grigoriadis
wiley   +1 more source

The molecular pathological basis and potential clinical applications of ‘zero‐budding’ status in stage II colorectal cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 6, November 2026.
Abstract In the personalized management of stage II colorectal cancer (CRC), traditional TNM (Tumor, Node, Metastasis) staging has limited ability to accurately stratify the risk of postoperative recurrence. Consequently, oncologists frequently face a major therapeutic dilemma when determining the use of adjuvant chemotherapy in these patients ...
Ying‐nan Liu, Ben Wang, Qian Xu
wiley   +1 more source

Identification of C3d Complement Fragments in Lesional Tissues in ANCA‐Associated Vasculitis

ACR Open Rheumatology, Volume 8, Issue 11, November 2026.
Objective Antineutrophil cytoplasmic antibody–associated vasculitis (AAV) is typically described as “pauci‐immune” due to the absence or weak detection of Igs and complement activation within AAV tissue lesions. However, complement fragments have been recently reported in significant amounts in damaged tissue in AAV, notably in traps formed by ...
Claire Galand, Fei Liu, Katherine A. Vernon, Ravi Vats, Christine Lian, V. Michael Holers, Michael Woodbury, H. Terence Cook, David Cuthbertson, Nader Khalidi, Curry Koening, Carol A. Langford, Carol A. McAlear, Paul A. Monach, Christian Pagnoux, Jason A. Campagna, Stefan Wawersik, Shelia Violette, Peter A. Merkel, for the Vasculitis Clinical Research Consortium   +19 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, Volume 38, Issue 61, 2 November 2026.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

The problem with neoantigen prediction [PDF]

Nature Biotechnology, 2017
openaire   +2 more sources

Photoacoustic Nanotagging for In Vivo Tracking and Optimization of Macrophage Immunotherapy in Solid Tumors

Advanced Materials, Volume 38, Issue 61, 2 November 2026.
Macrophage‐based immunotherapy for solid tumors is limited by poor tracking of cell localization and persistence. This study introduces nanotagged macrophages enabling near‐infrared photoacoustic imaging for real‐time monitoring. IFNγ‐conjugated tags enhance antitumor polarization without harming viability.
Seoyoon Song, Melissa Cadena, Myeongsoo Kim, Euisuk Chung, Jeungyoon Lee, Zlata Brushevich, Seonghun Shin, Paul S. Pelkowski, Stanislav Y. Emelianov   +8 more
wiley   +1 more source