Results 131 to 140 of about 25,910 (264)

Identification of public neoantigens with broad HLA class I coverage as candidates for off-the-shelf cancer vaccine development in colorectal cancer

Frontiers in Immunology
IntroductionShared neoantigens derived from recurrent mutations represent promising targets for off-the-shelf (OTS) cancer immunotherapies; however, their clinical utility is often constrained by population-specific HLA diversity and variable ...
Diem TP Tran, Bui Que Tran Nguyen, Bui Que Tran Nguyen, Huu Thinh Nguyen, Thi Mong Quynh Pham, Dinh Viet Linh Nguyen, Thanh Nhan Nguyen, Thi Kim Cuong Ho, Vy Nguyen, Pham Trung Dung Nguyen, Duc Huy Tran, Thanh Sang Tran, Truong-Vinh Ngoc Pham, Minh-Triet Le, Hoa Giang, Hoai Nghia Nguyen, Minh-Duy Phan, Le Son Tran   +17 more
doaj   +1 more source

Australian consensus recommendations for the management of increased meningococcal infection risk in adults with neurological diseases treated with complement inhibitors

Internal Medicine Journal, EarlyView.
Abstract Complement inhibitor therapy carries a risk of serious infections, including meningococcal disease. Here we provide evidence‐based recommendations and expert consensus for immunisation and prophylactic treatment of patients receiving, or planning to receive, complement inhibitors for neurological conditions in the Australian setting.
Katherine A. Buzzard, Michael Barnett, Heidi Beadnall, Mirasol Forcadela, Lesley‐Ann Hall, Victoria G. Hall, Todd Hardy, Danny Hsu, Paul Kinsella, Mastura Monif, Sudarshini Ramanathan, Stephen W. Reddel, Sean Riminton, Douglas F. Johnson   +13 more
wiley   +1 more source

Targeting B7-H3 enhances the efficacy of neoantigen-based cancer vaccine in combination with radiotherapy

npj Vaccines
The clinical response to immune checkpoint blockade (ICB) is limited in the majority of patients with colorectal cancer. These immune checkpoint proteins may not only inhibit T-cell-mediated antitumor immunity but also attenuate antigen presentation ...
Tao-Wei Ke, Chia-Yi Chen, William Tzu-Liang Chen, Yuan-Yao Tsai, Shu-Fen Chiang, Chi-Hsien Huang, Yu-Sen Lin, Te-Hong Chen, Tsung-Wei Chen, Ji-An Liang, K. S. Clifford Chao, Kevin Chih-Yang Huang   +11 more
doaj   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Periodontal Medicine Rewired: Mechanisms Linking Periodontitis to Systemic Diseases

Journal of Periodontal Research, EarlyView.
This review reorganizes decades of research in periodontal medicine into a multi‐dimensional framework, illustrating how periodontitis influences systemic health through at least seven interconnected mechanisms. ABSTRACT Periodontitis is now recognized not merely as a localized oral condition but as a systemic disease linked to over 70 communicable and
Mario Romandini, George Hajishengallis, Mike Curtis, Giacomo Baima   +3 more
wiley   +1 more source

NeoTImmuML: a machine learning-based prediction model for human tumor neoantigen immunogenicity

Frontiers in Immunology
IntroductionTumor neoantigens possess high specificity and immunogenicity, making them crucial targets for personalized cancer immunotherapies such as mRNA vaccines and T-cell therapies.
Yan Shao, Shuguang Ge, Ruizhe Dong, Wei Ji, Chaoran Qin, Pengbo Wen   +5 more
doaj   +1 more source

Metabolic reprogramming of the immune response in periodontitis

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis, a highly prevalent chronic inflammatory disease, is characterized by the progressive destruction of the tooth‐supporting tissues, ultimately causing tooth loss. In recent years, the emerging field of immunometabolism has revealed that immune cell function is tightly regulated by intracellular metabolic pathways that ...
Rafael Scaf de Molon, Melissa Grant, Iain Chapple, Joao Paulo Steffens   +3 more
wiley   +1 more source

Correction to: NeoFox: annotating neoantigen candidates with neoantigen features

Bioinformatics, 2023
openaire   +2 more sources

Immunohistochemical Characterisation of Mismatch Repair Proteins in Feline Cancers: A Pilot Study Using Validated Cross‐Reactive Antibodies

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT DNA mismatch repair (MMR) deficiency is a clinically important biomarker in human oncology, yet its relevance in feline neoplasia remains poorly understood due to limited characterisation and the absence of validated reagents. In this study, we established a practical immunohistochemistry (IHC) approach for evaluating feline MMR proteins by ...
Shoma Nishibori, Masashi Sakurai, Yumiko Kagawa, Kazuo Nishigaki, Takayuki Nakagawa, Sakuya Inanaga, Masaya Igase, Takuya Mizuno   +7 more
wiley   +1 more source

Neoantigen-Displaying Protein Nanoparticles as a Therapeutic Cancer Vaccine Against Melanoma

Although interest in peptide-based cancer vaccines has surged in the era of personalized immunotherapy enabled by the discovery of neoantigens, the effective generation of neoantigen-specific T cell responses has been limited.
Yoon, Jungmin, Kang, Sukmo, Woo, Sangmin, Lee, Seojung, Kim, Sun-Young, Song, Ji-Joon, Jon, Sangyong, Shin, Yumi, Kim, Yujin   +8 more
core   +1 more source