Results 111 to 120 of about 25,910 (264)

Shared neoantigens for cancer immunotherapy

Molecular Therapy Oncology
Exploration of neoantigens holds the potential to be productive in immuno-oncotherapy. Among tumor-specific antigens, neoantigens result from genetic instability that gives rise to non-synonymous somatic mutations, highly specific to tumor cells.
Goloudina, Anastasia, Le Chevalier, Fabien, Authié, Pierre, Charneau, Pierre, Majlessi, Laleh   +4 more
openaire   +4 more sources

Neoantigen Quality Predicts Immune Response, Survival

, 2018
A new mathematical model finds that tumor neoantigen quality trumps quantity when it comes to predicting response to immunotherapy and the likelihood of long-term survival among patients with cancer.

core   +1 more source

Biomarkers Predictive of Immunotherapy Efficacy in Head and Neck Squamous Cell Carcinoma: Current Insights and Future Perspectives

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT With the approval of immunotherapies by regulatory bodies, head and neck squamous cell carcinoma (HNSCC) treatment has been revolutionized, and anti‐programmed cell death‐1 (anti‐PD‐1) agents are now the standard for platinum‐resistant recurrent/metastatic HNSCC.
Xiao‐Tong Yan, Zhao‐Hong An, Chang‐Ming An   +2 more
wiley   +1 more source

Supplementary data to: Detection of Neoantigen-specific T Cells Following a Personalized Vaccine in a Patient with Glioblastoma

, 2018
Supplemental Data for the patient described in the manuscript: "Detection of Neoantigen-specific T Cells Following a Personalized Vaccine in a Patient with Glioblastoma".
Chicoine, Michael (5830721), Johanns, Tanner, Miller, Christopher, Fritsch, Edward (5830730), Gillanders, William, Huang, Jiayi, Schreiber, Robert (5830742), Perrin, Richard (5830709), Bender, Diane (5830712), Huang, Jiayi (5830727), Dunn, Gavin (5830745), Dunn, Gavin, Campian, Jian (5830718), Artymov, Maxim, Schreiber, Robert, Johanns, Tanner (5830700), Kobayashi, Dale, Kobayashi, Dale (5830715), Artymov, Maxim (5830736), Mardis, Elaine, Miller, Christopher (5830703), Bender, Diane, Gillanders, William (5830733), Dacey, Ralph, Liu, Connor (5830706), Liu, Connor, Fritsch, Edward, Perrin, Richard, Dacey, Ralph (5830724), Chicoine, Michael, Campian, Jian, Mardis, Elaine (5830739)   +31 more
core   +1 more source

Systemic Therapy Management Strategies for Early‐Stage Breast Cancer in Australia

Asia-Pacific Journal of Clinical Oncology, EarlyView.
Advances in systemic therapy for early‐stage breast cancer in Australia highlight genomic‐guided decisions, subtype‐specific strategies, and emerging targeted and immunotherapies, shaping personalized and de‐escalated treatment approaches. ABSTRACT Breast cancer is the most common cancer among Australian women, with early‐stage disease (Stages I, II ...
Nicholas Zdenkowski, Rachel Dear, Sanjeev Kumar, Hilary Martin, Dhanusha Sabanathan, Stephen J. Luen, Belinda Yeo   +6 more
wiley   +1 more source

A Spotlight on Yolk‐sac Tumors: Molecular Pathology, Current Diagnostics, and Novel Therapeutics

Andrology, EarlyView.
ABSTRACT Background Yolk‐sac tumors are an aggressive subtype of testicular cancer that significantly contribute to disease progression and therapy resistance, especially in adults. While testicular cancer generally has high cure rates with cisplatin‐based treatment, adult yolk‐sac tumors often appear as components of mixed tumors with poor response to
Evangelos Prokakis, Lisa Schneider, Felix Bremmer, Daniel Nettersheim   +3 more
wiley   +1 more source

Molecular origin, discovery, validation and application of neoantigens

Asian Journal of Pharmaceutical Sciences
Neoantigens, tumor-specific peptides originating from somatic mutations, are pivotal targets for personalized cancer immunotherapy. This review synthesizes current neoantigen research, encompassing its molecular origins, discovery methodologies ...
Qian Lyu, Shen Hu
doaj   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source

neoantigen

Citation: 'neoantigen' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13504 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source