Results 91 to 100 of about 25,910 (264)

DataSheet_1_Combination treatment of radiofrequency ablation and peptide neoantigen vaccination: Promising modality for future cancer immunotherapy.docx

, 2022
BackgroundThe safety and immunogenicity of a personalized neoantigen-based peptide vaccine, iNeo-Vac-P01, was reported previously in patients with a variety of cancer types.
Shanshan Zhang (50616), Ning Han (217435), Liang Liu (50022), Fan Mo (201014), Dongying Ma (132065), Qianpeng Guo (11561407), Hongming Pan (194459), Lantian Lu (11270904), Hongseng Li (13882418), Shuqing Chen (284288), Jiawei Shou (10966131), Yong Fang (301344), Xiaomeng Zhang (182897), Qinxue Huang (11270907), Weidong Han (102395), Xiaojie Guo (714976), Min Qiu (324481), Shengli Ye (13882421)   +17 more
core   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines.

PLoS ONE, 2016
Due to advances in sequencing technology, somatically mutated cancer antigens, or neoantigens, are now readily identifiable and have become compelling targets for immunotherapy.
Spencer D Martin, Spencer D Martin, Scott D Brown, Darin A Wick, Julie S Nielsen, David R Kroeger, Kwame Twumasi-Boateng, Robert A Holt, Brad H Nelson   +8 more
doaj   +1 more source

Additional file 2: of Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer

, 2019
Figure S2. Comparison of somatic mutation and neoantigen between primary and local invasive tumors. (a) Somatic mutation. (b) Neoantigen. Pt #02 on the left and Pt #10 on the right. X-axis: variant allele frequency (VAF) in WES of primary tumor.
George Maxwell (6863609), Jianmin Wang (59025), Richard Koya (6192584), Song Yao (202481), Laiping Wong (3834409), Qianqian Zhu (48100), Nicholas Bateman (6863606), Junko Matsuzaki (209854), Mark Long (3721837), Takemasa Tsuji (209850), Song Liu (9858), Eduardo Cortes (6863603), Li Yan (107001), Shashikant Lele (122694), Amit Lugade (6863612), Kunle Odunsi (122690), Lei Wei (18880), Thinle Chodon (241903), Anthony Miliotto (209865), Sebastiano Battaglia (674413), Qiang Hu (122686), Thomas Conrads (2990535)   +21 more
core   +1 more source

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Supplementary Figure from Quantification of Neoantigen-Mediated Immunoediting in Cancer Evolution

, 2022
Supplementary Figure from Quantification of Neoantigen-Mediated Immunoediting in Cancer ...
Xuan Wang (55634), Ziyu Tao (10746206), Xue-Song Liu (14958963), Shixiang Wang (14958957), Guangshuai Wang (12872735), Tao Wu (14958954), Xiangyu Zhao (14958960), Chenxu Wu (8790332), Wei Ning (430798), Fuxiang Chen (5162699)   +9 more
core   +1 more source

The T‐Cell Response Mechanism in Human Papillomavirus‐Associated Cervical Cancer and New Strategies for Immunotherapy

iNew Medicine, EarlyView.
ABSTRACT Human papillomavirus (HPV) is a double‐stranded DNA virus that infects human skin and mucosal tissues exclusively. The German scientist Harald zur Hausen was awarded the 2008 Nobel Prize in Physiology or Medicine for his discovery of the link between HPV infection and cervical cancer.
Fang Zhu, Farah Nazir, Ying Zhou, Yuhua Shang, Hongliang He, Tengchuan Jin   +5 more
wiley   +1 more source

The Development of Tumor Neoantigen Vaccine Immunotherapy

, 2019
Activating the immune system to fight against cancers has long been a goal in immunology and oncology studies. Recent clinical-trial data proved that boosting the activity of endogenous T cells to destroy cancer cells has great potential in controlling ...
Wanqiu Wang, Wang Wanqiu
core   +1 more source

Identification of neoantigen-reactive T lymphocytes in the peripheral blood of a patient with glioblastoma

, 2021
The adoptive transfer of naturally occurring T cells that recognize cancer neoantigens has led to durable tumor regressions in select patients with cancer.
Rami Yossef, Vid Leko, Biman Paria, Steven A Rosenberg, Paul Robbins, Jared J Gartner, Stephanie L Goff, Gal Cafri, Victoria Hill, Todd D Prickett, Devikala Gurusamy, Yong-Chen Lu, Zhili Zheng   +12 more
core   +1 more source

Specific peptide enrichment strategies for neuropsychiatric disorders: From material design to diagnostic applications

Interdisciplinary Medicine, EarlyView.
This review outlines specific peptide enrichment strategies, including metal, magnetic oxides, functional polymers, and antibody‐based approaches, and their mechanisms, highlighting applications in biomarker discovery for major neurological and psychiatric disorders.
Xue Zhang, Yejiao Shi, Minghui Guo, Yang Huang, Yirong Wang, Leping Huang, Helena S. Azevedo, Honggang Hu, Xin Dong   +8 more
wiley   +1 more source