Results 71 to 80 of about 25,910 (264)

RNA sequencing enables neoantigen discovery and vaccine validation in breast and lung cancer

Frontiers in Immunology
IntroductionNeoantigens have emerged as promising targets for personalized cancer immunotherapy due to their tumor-specific immunogenicity. However, current neoantigen prediction methods relying on combined DNA/RNA sequencing are costly and time ...
Hongye Hu, Yicheng Xiong, Danhong Lu, Weihong Sun, Xiaoping Su, Xiaoping Su, Xiaoping Su, Danni Mo, Lu Chen, Guan Wang, Jiayan Wang, Xiaohua Zhang, Mingdong Lu, Guanli Huang   +13 more
doaj   +1 more source

Comprehensive analysis of neoantigens derived from structural variation across whole genomes from 2528 tumors

Genome Biology, 2023
Background Neoantigens are critical for anti-tumor immunity and have been long-envisioned as promising therapeutic targets. However, current neoantigen analyses mostly focus on single nucleotide variations (SNVs) and indel mutations and seldom consider ...
Yang Shi, Biyang Jing, Ruibin Xi
doaj   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes

Advanced Science, EarlyView.
The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu, Zhiyue Fan, Lin Lv, Wei Lu, Zhenfan Wen, Wukun Liu   +5 more
wiley   +1 more source

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

Advanced Science, EarlyView.
TROP2 is identified as a novel tumor‐selective lysosomal‐targeting receptor with established clinical relevance. TROP2‐targeting chimeras (TRTACs) are developed by genetically fusing a TROP2‐binding nanobody to nanobodies against specific target proteins.
Luping Chen, Xinying Fu, Wenqian Dong, Xiaobei Deng, Simin Chen, Fujun Wang, Jian Zhao, Shiqun Shao, Liqiang Fan, Jingyu Zhang, Lixin Zhang   +10 more
wiley   +1 more source

Neoantigen load as a predictor of relapse in early-stage NSCLC: features that agonise and antagonise prognosis

Cancer Immunology, Immunotherapy
Background Neoantigen-specific immune responses may help prevent cancer recurrence. We evaluated whether neoantigen load and/or properties could predict survival in early-stage non-small cell lung cancer (NSCLC). Methods Whole-exome sequencing (WES) data
Linda Ye, Ian Dick, Bruce W. Robinson, Jenette Creaney, Alec Redwood   +4 more
doaj   +1 more source

Identification of neoantigens derived from alternative splicing and RNA modification [PDF]

Genomics & Informatics, 2019
The acquisition of somatic mutations is the most common event in cancer. Neoantigens expressed from genes with mutations acquired during carcinogenesis can be tumor-specific.
Jiyeon Park, Yeun-Jun Chung
doaj   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Tumor neoantigens: from basic research to clinical applications

Journal of Hematology & Oncology, 2019
Tumor neoantigen is the truly foreign protein and entirely absent from normal human organs/tissues. It could be specifically recognized by neoantigen-specific T cell receptors (TCRs) in the context of major histocompatibility complexes (MHCs) molecules ...
Tao Jiang, Tao Shi, Henghui Zhang, Jie Hu, Yuanlin Song, Jia Wei, Shengxiang Ren, Caicun Zhou   +7 more
doaj   +1 more source

Can Chemoradiotherapy Expand Immune Checkpoint Blockade Responsiveness in Mismatch Repair‐Proficient Rectal Cancer?

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset of pMMR tumors, suggesting that clinical ...
Kimihiro Yamashita, Takeru Matsuda, Junko Mukohyama, Ryohei Sasaki, Yoshihiro Kakeji   +4 more
wiley   +1 more source