Results 61 to 70 of about 25,910 (264)

Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes

Journal for ImmunoTherapy of Cancer
Background Tumor-infiltrating lymphocytes (TILs) targeting neoantigens can effectively treat a selected set of metastatic solid cancers. However, harnessing TILs for cancer treatments remains challenging because neoantigen-reactive T cells are often rare
Yong Li, Steven A Rosenberg, Paul F Robbins, Zhiya Yu, Maria Parkhurst, Billel Gasmi, Nikolaos Zacharakis, Todd D Prickett, Jared J Gartner, Sri Krishna, Stephanie L Goff, Satyajit Ray, Frank J Lowery, Sivasish Sindiri, Alakesh Bera, Noam Levin, Sanghyun P Kim, Charles A Marquardt, Nolan R Vale, Lior Levy, Tiffany Benzine, Robert V Masi, Rafiqul Islam   +22 more
doaj   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

CNNeoPP: a large language model-enhanced deep learning pipeline for personalized neoantigen prediction and liquid biopsy applications

Frontiers in Immunology
Neoantigens have emerged as promising targets for personalized cancer immunotherapy. However, accurate identification of immunogenic neoantigens remains a challenge due to limitations in existing predictive models.
Yu Cai, Rui Chen, Mingming Song, Lei Wang, Zirong Huo, Dongyan Yang, Sitong Zhang, Shenghan Gao, Seungyong Hwang, Ling Bai, Yonggang Lv, Yali Cui, Xi Zhang   +12 more
doaj   +1 more source

Neoantigen-directed immune escape in lung cancer evolution

, 2020
The interplay between an evolving cancer and a dynamic immune microenvironment remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell lung cancers using RNA sequencing and histopathology-assessed tumour-infiltrating ...
Mariam Jamal-Hanjani (594401), Kroopa Joshi (7783976), Jonas Demeulemeester (180282), Gareth A Wilson (9228752), The TRACERx Consortium (9552683), Roberto Salgado (8458), Andrew Feber (3559562), Jake Y Henry (8985065), Javier Herrero (10236), Sergio A Quezada (8985089), James L Reading (9203984), Peter Van Loo (9838), Tom Lund (9552680), Zoltan Szallasi (58337), Elizabeth Larose Cadieux (7421605), David A Moore (3639136), Nicholas McGranahan (594459), Miljana Tanić (5808959), Benny Chain (133611), Stephan Beck (5246), Nicolai J Birkbak (8990522), Rachel Rosenthal (3437186), Selvaraju Veeriah (594454), Sherene Loi (52471), Matthew D Hellmann (9203993), Maise Al Bakir (8842397), Crispin T Hiley (9265343), Ehsan Ghorani (8985056), Charles Swanton (236153)   +28 more
core  

A liposomal RNA vaccine inducing neoantigen-specific CD4+ T cells augments the antitumor activity of local radiotherapy in mice

OncoImmunology, 2020
Antigen-encoding, lipoplex-formulated RNA (RNA-LPX) enables systemic delivery to lymphoid compartments and selective expression in resident antigen-presenting cells.
Nadja Salomon, Fulvia Vascotto, Abderaouf Selmi, Mathias Vormehr, Juliane Quinkhardt, Thomas Bukur, Barbara Schrörs, Martin Löewer, Mustafa Diken, Özlem Türeci, Ugur Sahin, Sebastian Kreiter   +11 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Best practices for bioinformatic characterization of neoantigens for clinical utility

Genome Medicine, 2019
Neoantigens are newly formed peptides created from somatic mutations that are capable of inducing tumor-specific T cell recognition. Recently, researchers and clinicians have leveraged next generation sequencing technologies to identify neoantigens and ...
Megan M. Richters, Huiming Xia, Katie M. Campbell, William E. Gillanders, Obi L. Griffith, Malachi Griffith   +5 more
doaj   +1 more source

Co-stimulatory Molecules Improve the Immune Response to a Weak Neoantigen [PDF]

61 pagesTherapeutic cancer vaccines are an emerging cancer immunotherapy that work by educating the host’s immune system to attack cancer cells within the body.
Quinones, Estefani
core   +1 more source

Overcoming Drug Resistance by Paclitaxel Resistance in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Bo Chen, Yangyi Wang, Tingting Li, Changqing Guo, Zhe Xie, Zhixian Zhang, Xinghua Han, Wei Wang, Jian Wang, Xiaopeng Ma, Yuanzeng Min   +10 more
wiley   +1 more source

Recombinant ferritin-based nanoparticles as neoantigen carriers significantly inhibit tumor growth and metastasis

Journal of Nanobiotechnology
Background Tumor neoantigen peptide-based vaccines, systemic immunotherapies that enhance antitumor immunity by activating and expanding antigen-specific T cells, have achieved remarkable results in the treatment of a variety of solid tumors.
Wei Zheng, Shixiong Li, Zhongliang Shi, Kailing Su, Yu Ding, Luyue Zhang, Qian Tang, Jiani Han, Han Zhao, Fengwei Wang, Hongru Zhang, Zhangyong Hong   +11 more
doaj   +1 more source