Results 81 to 90 of about 25,910 (264)

AI‐Driven Cancer Multi‐Omics: A Review From the Data Pipeline Perspective

Advanced Intelligent Discovery, EarlyView.
The exponential growth of cancer multi‐omics data brings opportunities and challenges for precision oncology. This review systematically examines AI's role in addressing these challenges, covering generative models, integration architectures, Explainable AI for clinical trust, clinical applications, and key directions for clinical translation.
Shilong Liu, Shunxiang Li, Kun Qian
wiley   +1 more source

Anti–Carbamylated Fibrinogen Autoantibodies of IgG and IgA Isotypes Contribute to a Better Prognostic Stratification in Very Early Rheumatoid Arthritis: Data From the French National ESPOIR Cohort

Arthritis &Rheumatology, EarlyView.
Objective The aim of this study was to investigate the prevalence and longitudinal evolution of anti–carbamylated fibrinogen antibodies (ACa‐Fib) of IgG and IgA isotypes in early rheumatoid arthritis (RA) and determine whether these antibodies provide additional diagnostic and prognostic information beyond anti–cyclic citrullinated peptide (anti‐CCP ...
Pauline Brevet, Olivia Guérin, Léna Le Goaréguer, Élisa Halbourg, Marie‐Laure Golinski, Sophie Candon, Olivier Boyer, Thierry Lequerré, Thierry Schaeverbeke, Valérie Devauchelle‐Pensec, Olivier Vittecoq, Manuel Fréret   +11 more
wiley   +1 more source

Establishment of a novel tumor neoantigen prediction tool for personalized vaccine design

Human Vaccines & Immunotherapeutics
The personalized neoantigen nanovaccine (PNVAC) platform for patients with gastric cancer we established previously exhibited promising anti-tumor immunoreaction.
Kai Xin, Xiao Wei, Jie Shao, Fangjun Chen, Qin Liu, Baorui Liu   +5 more
doaj   +1 more source

Nanomedicine‐driven innovations in postoperative cancer immunotherapy: Remodeling tumor microenvironment and precision delivery strategies

BMEMat, EarlyView.
Nanomedicine‐Driven Strategies for Suppressing Postoperative Tumor Recurrence. This schematic illustrates three pivotal nanomedical strategies that synergistically counteract recurrence by targeting residual disease and the immunosuppressive tumor microenvironment within the surgical cavity.
Lisong Pang, Zhuomin Wang, Zhenhua Jin, Ahmed H. Ghonaim, Hengcheng Zhang, Xinyu You, Jinzhuo Ning, Jiaqing Cao, Yang Liu   +8 more
wiley   +1 more source

Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4

, 2019
Background: The efficacy of checkpoint blockade immunotherapies in colorectal cancer is currently restricted to a minority of patients diagnosed with mismatch repair-deficient tumors having high mutation burden. However, this observation does not exclude
Ijsselsteijn, M.E., Breggen, R. van der, Peeters, K.C.M.J., Ruano, D., Oosting, J., Farina-Sarasqueta, A., Verdegaal, E.M.E., Visser, M., Vries, N.L. de, Miranda, N.F.C.C. de, Duhen, T., Weinberg, A.D., Burg, S.H. van der, Ploeg, M. van der, Bulk, J. van den   +14 more
core   +1 more source

Additional file 11 of Personalized neoantigen vaccine prevents postoperative recurrence in hepatocellular carcinoma patients with vascular invasion

, 2021
Additional file 11: Supplementary Table S2.
Zhixiong Cai (1778461), Xiaoping Su (558134), Liman Qiu (11833693), Xiuqing Dong (129112), Liuping Luo (10970634), Fuqun Wei (10970628), Geng Chen (194556), Yingchao Wang (2805157), Yang Zhou (65942), Hengkai Chen (10057963), Xiaolong Liu (8982539), Xiaolou Li (11833696), Zhenli Li (383719), Yongyi Zeng (1392457)   +13 more
core   +1 more source

Bridging the translational gap in clinical nanomedicine: From rational design to clinical reality

BMEMat, EarlyView.
Nanotechnology offers a multi‐faceted approach to modern healthcare, encompassing high‐sensitivity diagnostic imaging, innovative vaccine delivery, and targeted therapeutics. This review explores how these nanomedicine applications address critical challenges in cancer recurrence and the treatment of neurologic and respiratory diseases to combat rising
Ahmed H. Ghonaim, Marwa Ahmed El‐Naka, Wedad M. Nageeb, Atta Ullah Khan, Noura M. Seleem, Aliaa Abdelghafar, Doaa Zamel, Yang Liu, Qigai He, Wentao Li   +9 more
wiley   +1 more source

A dendritic cell vaccine for both vaccination and neoantigen-reactive T cell preparation for cancer immunotherapy in mice

Nature Communications
Adoptive cell transfer (ACT) using neoantigen-specific T cells is an effective immunotherapeutic strategy. However, the difficult isolation of neoantigen-specific T cells limits the clinical application of ACT.
Qing Li, Hao Zeng, Ting Liu, Peipei Wang, Rui Zhang, Binyan Zhao, Tang Feng, Yuling Yang, Jiumei Wu, Yue Zheng, Bailing Zhou, Yang Shu, Heng Xu, Li Yang, Zhenyu Ding   +14 more
doaj   +1 more source

Tumor neoantigen heterogeneity impacts bystander immune inhibition of pancreatic cancer growth [PDF]

, 2020
The immunogenic clonal-fraction threshold in heterogeneous solid-tumor required to induce effective bystander-killing of non-immunogenic subclones is unknown.
Liu, Y, Das, A, Das, M, Vincent, B.G, Li, J, Zhou, X, Huang, L, Liu, R   +7 more
core   +1 more source

Obesity and Pathologic Response to Neoadjuvant Immunotherapy in Head and Neck Cancer: Preliminary Results From a Pilot Study

Head &Neck, EarlyView.
ABSTRACT Objective To evaluate associations between obesity and pathologic response to neoadjuvant immune checkpoint inhibitors (ICI) in patients with head and neck squamous cell carcinoma (HNSCC). Methods This was a retrospective cohort study conducted at a single tertiary academic center.
Angeline A. Truong, Laura Chen, Rex H. Lee, Xin Wu, Hyunseok Kang, Ivan H. El‐Sayed, Jonathan R. George, Chase M. Heaton, Ilya Likhterov, Michael Chow, Mary Jue Xu, Patrick K. Ha, Alain P. Algazi, Katherine C. Wai   +13 more
wiley   +1 more source