Results 41 to 50 of about 25,910 (264)

Neoantigens:

, 2022
The expression of non-synonymous mutations can result in the production of neoantigens, which are tumor-specific antigens. Neoantigens, or tumor-specific antigens, can be produced as a result of the expression of non-synonymous mutations.
openaire   +1 more source

SIGANEO: Similarity network with GAN enhancement for immunogenic neoepitope prediction

Computational and Structural Biotechnology Journal, 2023
Target selection of the personalized cancer neoantigen vaccine, which is highly dependent on computational prediction algorithms, is crucial for its clinical efficacy.
Yilin Ye, Yiming Shen, Jian Wang, Dong Li, Yu Zhu, Zhao Zhao, Youdong Pan, Yi Wang, Xing Liu, Ji Wan   +9 more
doaj   +1 more source

Neoantigens in precision cancer immunotherapy: from identification to clinical applications

Chinese Medical Journal, 2022
. Immunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass ...
Qiao Zhang, Qingzhu Jia, Jing Zhang, Bo Zhu, Peifang Wei   +4 more
doaj   +1 more source

Proteogenomic identification of an immunogenic HLA class I neoantigen in mismatch repair–deficient colorectal cancer tissue

JCI Insight, 2021
Although CD8+ T cells recognize neoantigens that arise from somatic mutations in cancer, only a small fraction of nonsynonymous mutations give rise to clinically relevant neoantigens.
Tomomi Hirama, Serina Tokita, Munehide Nakatsugawa, Kenji Murata, Yasuhito Nannya, Kazuhiko Matsuo, Hidetoshi Inoko, Yoshihiko Hirohashi, Shinichi Hashimoto, Seishi Ogawa, Ichiro Takemasa, Noriyuki Sato, Fumitake Hata, Takayuki Kanaseki, Toshihiko Torigoe   +14 more
doaj   +1 more source

Netie: Inferring the Evolution of Neoantigen-T Cell Interactions in Tumors [PDF]

, 2022
Neoantigens are the key targets of antitumor immune responses from cytotoxic T cells and play a critical role in affecting tumor progressions and immunotherapy treatment responses.
Han, Yi, Park, Seongoh, Wistuba, Ignacio, Reuben, Alexandre, Lu, Tianshi, Hubert, Shawna Marie, Zhang, Jianjun, Wang, Yunguan, Heymach, John V, Wang, Tao, Futreal, P Andy   +10 more
core   +1 more source

Personal Neoantigens From Patients With NSCLC Induce Efficient Antitumor Responses

Frontiers in Oncology, 2021
ObjectiveTo develop a neoantigen-targeted personalized cancer treatment for non-small cell lung cancer (NSCLC), neoantigens were obtained from collected human lung cancer samples, and the utility of neoantigen and neoantigen-reactive T cells (NRTs) was ...
Wei Zhang, Qi Yin, Haidong Huang, Jingjing Lu, Hao Qin, Si Chen, Wenjun Zhang, Xiaoping Su, Weihong Sun, Yuchao Dong, Qiang Li   +10 more
doaj   +1 more source

A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer

, 2020
Neoantigen vaccines have been enthusiastically pursued for personalized cancer immunotherapy while vast majority of neoantigens have no or low immunogenicity. Here, a bi-adjuvant neoantigen nanovaccine (banNV) that codelivered a peptide neoantigen (Adpgk)
Ni, Qianqian, Niu, Gang, Su, Ting, Lu, Guangming, Zhang, Longjiang, Liang, Brian, Liu, Yijing, Wang, Zhantong, Yu, Guocan, Zhu, Guizhi, Chen, Xiaoyuan, Zhang, Fuwu   +11 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Predicted neoantigen load in non-hypermutated endometrial cancers: Correlation with outcome and tumor-specific genomic alterations

Gynecologic Oncology Reports, 2017
Elevated neoantigen load has been previously correlated with improved outcome and response to immune checkpoint blockade in various tumor types. In endometrial cancer, previous studies of neoantigen load prediction have shown that the hypermutated MSI ...
Sachet A. Shukla, Brooke E. Howitt, Catherine J. Wu, Panagiotis A. Konstantinopoulos   +3 more
doaj   +1 more source

The Ways of Isolating Neoantigen-Specific T Cells

Frontiers in Oncology, 2020
Immunotherapy has revolutionized the standard of care for a range of malignancies. Accumulating evidence suggests that the success of immunotherapy is likely attributable to neoantigen-specific T cells.
Qing Li, Zhen-Yu Ding
doaj   +1 more source