Results 31 to 40 of about 25,910 (264)

Determinants for Neoantigen Identification [PDF]

Frontiers in Immunology, 2019
All tumors accumulate genetic alterations, some of which can give rise to mutated, non-self peptides presented by human leukocyte antigen (HLA) molecules and elicit T-cell responses. These immunogenic mutated peptides, or neoantigens, are foreign in nature and display exquisite tumor specificity.
Andrea Garcia-Garijo, Carlos Alberto Fajardo, Alena Gros   +2 more
openaire   +3 more sources

Neoantigens in Hematologic Malignancies

Frontiers in Immunology, 2020
T cell cancer neoantigens are created from peptides derived from cancer-specific aberrant proteins, such as mutated and fusion proteins, presented in complex with human leukocyte antigens on the cancer cell surface. Because expression of the aberrant target protein is exclusive to malignant cells, immunotherapy directed against neoantigens should avoid
Melinda A. Biernacki, Melinda A. Biernacki, Marie Bleakley, Marie Bleakley   +3 more
openaire   +3 more sources

Immune subtypes and neoantigen-related immune evasion in advanced colorectal cancer

iScience, 2022
Summary: Elimination of cancerous cells by the immune system is an important mechanism of protection from cancer, however, its effectiveness can be reduced owing to development of resistance and evasion.
Toshitaka Sugawara, Fuyuki Miya, Toshiaki Ishikawa, Artem Lysenko, Jo Nishino, Takashi Kamatani, Akira Takemoto, Keith A. Boroevich, Kazuhiro Kakimi, Yusuke Kinugasa, Minoru Tanabe, Tatsuhiko Tsunoda   +11 more
doaj   +1 more source

Personal neoantigen cancer vaccines: The momentum builds [PDF]

, 2014
Neoantigen-based cancer vaccines designed to target the unique immunogenic mutations arising in each patient’s tumor are breathing new life into a struggling approach. Data continue to demonstrate the importance of neoantigens in immune control of cancer.
Wu, Catherine, Fritsch, Edward F, Hacohen, Nir   +2 more
core   +1 more source

Efficient identification of neoantigen-specific T-cell responses in advanced human ovarian cancer

Journal for ImmunoTherapy of Cancer, 2019
Background Efficient identification of neoantigen-specific T-cell responses in epithelial ovarian cancer (EOC) remains a challenge. Existing investigations of spontaneous T-cell response to tumor neoepitope in EOC have taken the approach of comprehensive
Song Liu, Junko Matsuzaki, Lei Wei, Takemasa Tsuji, Sebastiano Battaglia, Qiang Hu, Eduardo Cortes, Laiping Wong, Li Yan, Mark Long, Anthony Miliotto, Nicholas W. Bateman, Shashikant B. Lele, Thinle Chodon, Richard C. Koya, Song Yao, Qianqian Zhu, Thomas P. Conrads, Jianmin Wang, George L. Maxwell, Amit A. Lugade, Kunle Odunsi   +21 more
doaj   +1 more source

Editorial: The Clinical Application of Neoantigens [PDF]

Frontiers in Immunology, 2022
Editorial on the Research Topic The Clinical Application of ...
Jian-Guo Zhou, Jian-Guo Zhou, Jian-Guo Zhou, Jian-Guo Zhou, Zhenyu Ding, Huashan Shi, Min Cheng   +6 more
openaire   +3 more sources

Image_1_Immunological analysis of hybrid neoantigen peptide encompassing class I/II neoepitope-pulsed dendritic cell vaccine.jpeg

, 2023
Neoantigens/ are tumor-specific antigens that evade central immune tolerance mechanisms in the thymus. Long-term tumor-specific cytotoxic T lymphocyte activity maintenance requires class II antigen-reactive CD4+ T cells.
Norihiro Koya (17120866), Takafumi Morisaki (17120860), Sachiko Yoshimura (507146), Shinichiro Nakagawa (17120869), Poh Yin Yew (14994860), Hiroto Tanaka (243595), Kenta Tsujimura (17120872), Takashi Morisaki (17120875), Takanari Kitazono (483472), Hideya Onishi (17120857), Makoto Kubo (341120), Masafumi Nakamura (2368807), Shinji Morisaki (17120854), Kazuma Kiyotani (10785894), Masayo Umebayashi (17120863), Yusuke Nakamura (25445)   +15 more
core   +1 more source

Mutation-derived Neoantigen-specific T-cell Responses in Multiple Myeloma [PDF]

, 2020
PURPOSE: Somatic mutations in cancer cells can give rise to novel protein sequences that can be presented by antigen-presenting cells as neoantigens to the host immune system.
Alexander Solovyov, Dudley, Joel, Hearn Jay Cho, Deepak Perumal, Finnigan, John, Chari, Ajai, Naoko Imai, David Melnekoff, Joel T. Dudley, Melnekoff, David, Cho, Hearn, Violetta V. Leshchenko, Perumal, Deepak, Solovyov, Alexander, Joshua D. Brody, Alessandro Laganà, John Finnigan, Deepu Madduri, Nina Bhardwaj, Sacha Gnjatic, Bhardwaj, Nina, Brody, Joshua, Parekh, Samir, Greenbaum, Benjamin, Sundar Jagannath, Imai, Naoko, Madduri, Deepu, Samir Parekh, Jagannath, Sundar, Laganà, Alessandro, Ajai Chari, Gnjatic, Sacha, Benjamin Greenbaum, Leshchenko, Violetta   +33 more
core   +1 more source

Neoantigen Vaccine Delivery for Personalized Anticancer Immunotherapy [PDF]

, 2018
Cancer neoantigens derived from random somatic mutations in tumor tissue represent an attractive type of targets for the cancer immunotherapies including cancer vaccine. Vaccination against the tumor-specific neoantigens minimizes the potential induction
Yugang Guo, Kewen Lei, Li Tang, Guo, YG, Tang L, Guo Y, Lei K, Tang, L, Lei, KW   +8 more
core   +2 more sources

CAD v1.0: Cancer Antigens Database Platform for Cancer Antigen Algorithm Development and Information Exploration

Frontiers in Bioengineering and Biotechnology, 2022
Cancer vaccines have gradually attracted attention for their tremendous preclinical and clinical performance. With the development of next-generation sequencing technologies and related algorithms, pipelines based on sequencing and machine learning ...
Jijun Yu, Jijun Yu, Luoxuan Wang, Xiangya Kong, Yang Cao, Mengmeng Zhang, Mengmeng Zhang, Zhaolin Sun, Yang Liu, Jing Wang, Jing Wang, Beifen Shen, Beifen Shen, Xiaochen Bo, Jiannan Feng, Jiannan Feng   +15 more
doaj   +1 more source