Results 21 to 30 of about 25,910 (264)

Multiomics prediction and immunogenic validation of personalized neoantigens in cholangiocarcinoma patients [PDF]

Journal of Translational Medicine
Background Cholangiocarcinoma (CCA) is an aggressive biliary tract cancer with limited treatment options, underscoring the need for breakthrough precision therapies. Neoantigen-based therapy is a promising novel strategy for cancer treatment.
Baoluhe Zhang, Bao Jin, Xueshuai Wan, Xiao Liu, Xiang’an Wu, Jiali Xing, Yuxin Wang, Haifeng Xu, Yiyao Xu, Mei Guan, Yilei Mao, Yating Bai, Junqi Zhu, Qian Chen, Shunda Du   +14 more
doaj   +2 more sources

DNA-PK inhibition enhances neoantigen diversity and increases T cell responses to immunoresistant tumors

The Journal of Clinical Investigation
Effective antitumor T cell activity relies on the expression and MHC presentation of tumor neoantigens. Tumor cells can evade T cell detection by silencing the transcription of antigens or by altering MHC machinery, resulting in inadequate neoantigen ...
Allison J. Nielsen, Gabriella K. Albert, Amelia Sanchez, Jiangli Chen, Jing Liu, Andres S. Davalos, Degui Geng, Xander Bradeen, Jennifer D. Hintzsche, William Robinson, Martin McCarter, Carol Amato, Richard Tobin, Kasey Couts, Breelyn A. Wilky, Eduardo Davila   +15 more
doaj   +2 more sources

Profiling immunogenic neoantigen peptides elicited by personalized neoantigen vaccine in cancer patients [PDF]

Frontiers in Immunology
IntroductionPersonalized neoantigen vaccines can induce antitumor T cell responses, but only 10-20% of selected peptides have induced immune responses in patients, underscoring the limitations of current prediction strategies.MethodsWe analyzed a ...
Peng Zhao, Clara Effenberger, Saki Matsumoto, Takafumi Morisaki, Yu Ishii, Masayo Umebayashi, Hiroto Tanaka, Norihiro Koya, Shinichiro Nakagawa, Kenta Tsujimura, Yusuke Nakamura, Yusuke Nakamura, Takashi Morisaki, Kazuma Kiyotani, Kazuma Kiyotani   +14 more
doaj   +2 more sources

NeoFox: annotating neoantigen candidates with neoantigen features

Bioinformatics, 2021
Abstract Summary The detection and prediction of true neoantigens is of great importance for the field of cancer immunotherapy. Wesearched the literature for proposed neoantigen features and integrated them into a toolbox called NEOantigen Feature toolbOX (NeoFox).
Franziska Lang, Pablo Riesgo-Ferreiro, Martin Löwer, Ugur Sahin, Barbara Schrörs   +4 more
openaire   +3 more sources

Identification of neoantigens in esophageal adenocarcinoma [PDF]

Immunology, 2022
Abstract Esophageal adenocarcinoma (EAC) has a relatively poor long-term survival and limited treatment options. Promising targets for immunotherapy are short peptide neoantigens containing tumor mutations, presented to cytotoxic T-cells by human leukocyte antigen molecules (HLA).
Ben Nicholas, Alistair Bailey, Katy J. McCann, Oliver Wood, Robert C. Walker, Robert Parker, Nicola Ternette, Tim Elliott, Tim J. Underwood, Peter Johnson, Paul Skipp   +10 more
openaire   +3 more sources

tianshilu/QBRC-Neoantigen-Pipeline: First release

, 2021
QBRC Neoantigen calling pipeline with CSiN calculation ...
Neoantigen-pipeline, tianshilu
core   +1 more source

Targeting tumor heterogeneity with neoantigen-based cancer vaccines

, 2023
Neoantigen-based cancer vaccines have emerged as a promising immunotherapeutic approach to treat cancer. Nevertheless, the high degree of heterogeneity in tumors poses a significant hurdle for developing a vaccine that targets the therapeutically ...
Chen, Shuxiong, Ma, Linlin, Pounraj, Saranya, Mazzieri, Roberta, Rehm, Bernd HA, Dolcetti, Riccardo   +5 more
core   +1 more source

neoantigen pipeline

, 2023
<p>Neoantigen Prediction Pipeline</p> <p>Human Antigen Presentation Score</p ...
Zhu Xiuli
core   +1 more source

neoDL: a novel neoantigen intrinsic feature-based deep learning model identifies IDH wild-type glioblastomas with the longest survival

BMC Bioinformatics, 2021
Background Neoantigen based personalized immune therapies achieve promising results in melanoma and lung cancer, but few neoantigen based models perform well in IDH wild-type GBM, and the association between neoantigen intrinsic features and prognosis ...
Ting Sun, Yufei He, Wendong Li, Guang Liu, Lin Li, Lu Wang, Zixuan Xiao, Xiaohan Han, Hao Wen, Yong Liu, Yifan Chen, Haoyu Wang, Jing Li, Yubo Fan, Wei Zhang, Jing Zhang   +15 more
doaj   +1 more source

Personalized neoantigen vaccine prevents postoperative recurrence in hepatocellular carcinoma patients with vascular invasion

Molecular Cancer, 2021
Background Clinically, prophylactic anti-recurrence treatments for hepatocellular carcinoma (HCC) patients after radical surgery are extremely limited.
Zhixiong Cai, Xiaoping Su, Liman Qiu, Zhenli Li, Xiaolou Li, Xiuqing Dong, Fuqun Wei, Yang Zhou, Liuping Luo, Geng Chen, Hengkai Chen, Yingchao Wang, Yongyi Zeng, Xiaolong Liu   +13 more
doaj   +1 more source