Results 11 to 20 of about 25,910 (264)

Neoantigen quality, not quantity [PDF]

Science Translational Medicine, 2019
Prioritizing expressed clonal neoantigens in genes required for cancer cell survival may reduce the likelihood of resistance to neoantigen therapies.
Nicholas McGranahan, Charles Swanton
core   +6 more sources

The role of neoantigen in immune checkpoint blockade therapy

Experimental Hematology & Oncology, 2018
Immune checkpoint inhibitor induces tumor rejection by activated host immune system. The anti-tumor immune response consists of capture, presentation, recognition of neoantigen, as well as subsequent killing of tumor cell.
Ming Yi, Shuang Qin, Weiheng Zhao, Shengnan Yu, Qian Chu, Kongming Wu   +5 more
doaj   +2 more sources

Self-Assembling Peptide-Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy. [PDF]

Adv Sci (Weinh)
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Wu YF, Hu JC, Hu YF, Li WJ, Rong L, Li RH, Yao Y, Hu L, Wang XL, Zhang BZ, Lu Y, Chow SF, Su C, Yau T, Chung CY, Huang JD.   +15 more
europepmc   +2 more sources

Generalization of neoantigen-based tumor vaccine by delivering peptide-MHC complex via oncolytic virus

EMBO Molecular Medicine
Neoantigen vaccine is a promising breakthrough in tumor immunotherapy. However, the application of this highly personalized strategy in the treatment of solid tumors is hindered by several obstacles, including very costly and time-consuming preparation ...
Chenyi Wang, Yingjun Shi, Da Zhang, Yupeng Sun, Junjie Xie, Bingchen Wu, Cuilin Zhang, Xiaolong Liu   +7 more
doaj   +2 more sources

Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood [PDF]

Cell Reports, 2019
Summary: Neoantigen-specific T cells are increasingly viewed as important immunotherapy effectors, but physically isolating these rare cell populations is challenging.
Songming Peng, Jesse M. Zaretsky, Alphonsus H.C. Ng, William Chour, Michael T. Bethune, Jongchan Choi, Alice Hsu, Elizabeth Holman, Xiaozhe Ding, Katherine Guo, Jungwoo Kim, Alexander M. Xu, John E. Heath, Won Jun Noh, Jing Zhou, Yapeng Su, Yue Lu, Jami McLaughlin, Donghui Cheng, Owen N. Witte, David Baltimore, Antoni Ribas, James R. Heath   +22 more
doaj   +3 more sources

Superior in-vivo efficacy of integrated tumor neoantigen vaccination with adoptive neoantigen-reactive T-cell therapy in solid tumor [PDF]

Translational Oncology
Objective: Neoantigens from tumor mutations are key cancer immunotherapy targets. This study evaluated the efficacy of combined immunotherapy (neoantigen vaccines + adoptive neoantigen-reactive T cells, NRT) in solid tumors to lay a foundation for ...
Guozheng Liang, Boyue Zhang, Dan Chen, Qianmei Chen, Lichang Lai, Zifeng Su, Qingzhao Ruan, Runsheng Ruan   +7 more
doaj   +2 more sources

Neoantigen nanovaccines for cancer immunotherapy: design strategies, translational bottlenecks, and clinical prospects [PDF]

Journal of Nanobiotechnology
Neoantigen vaccines have become an important direction in cancer immunotherapy because mutation-derived tumor antigens can induce highly specific T-cell responses while minimizing immune tolerance associated with tumor-associated antigens. However, their
Mengqi Sun, Liang Xiao, Yongqiang Yu
doaj   +2 more sources

Immune-based mutation classification enables neoantigen prioritization and immune feature discovery in cancer immunotherapy

OncoImmunology, 2021
Genetic mutations lead to the production of mutated proteins from which peptides are presented to T cells as cancer neoantigens. Evidence suggests that T cells that target neoantigens are the main mediators of effective cancer immunotherapies.
Peng Bai, Yongzheng Li, Qiuping Zhou, Jiaqi Xia, Peng-Cheng Wei, Hexiang Deng, Min Wu, Sanny K. Chan, John W. Kappler, Yu Zhou, Eric Tran, Philippa Marrack, Lei Yin   +12 more
doaj   +3 more sources

CpG-ODN Facilitates Effective Intratracheal Immunization and Recall of Memory against Neoantigen-Expressing Alveolar Cells [PDF]

Frontiers in Immunology, 2017
Intrapulmonary immune reactions are impaired by the tolerogenic environment of the lung. This is manifested by the absence of effective endogenous T cell responses upon neoantigen expression.
Mathias Riehn, Marcin Cebula, Hansjörg Hauser, Dagmar Wirth, Dagmar Wirth   +4 more
doaj   +2 more sources

Neoantigen Controversies [PDF]

Annual Review of Biomedical Data Science, 2021
Next-generation sequencing technologies have revolutionized our ability to catalog the landscape of somatic mutations in tumor genomes. These mutations can sometimes create so-called neoantigens, which allow the immune system to detect and eliminate tumor cells.
Castro, Andrea, Zanetti, Maurizio, Carter, Hannah   +2 more
openaire   +3 more sources