Results 211 to 220 of about 25,910 (264)

Inverse relationship between neoantigen clonality and T-cell activity reveals distinct immune phenotypes in HNSCC. [PDF]

J Transl Med
Saravi B, Singh DD, Schorn L, Lommen J, Schrader F, Wilkat M, Vollmer A, Vollmer M, Hartmann S, Hörner M, Adhikari K, Roider E, Wollborn J, Kübler N, Sproll C.   +14 more
europepmc   +1 more source

A Deep Learning-Driven Framework Integrating Organoid-Based Functional Validation Identifies Universal Neoantigens from Recurrent Glioma Mutations. [PDF]

Cancer Res
Wang C, Sun T, He Y, Yu M, Pan CQ, Hu H, Sun Y, Wang D, Cui Z, Zhang J, Zhai Y, Shi Z, Li Z, Xu M, Oh YT, Jiang T, Xu Z, Li G, Zhang J, Zhang W.   +19 more
europepmc   +1 more source

Personalized neoantigen-pulsed autologous dendritic cells in newly-diagnosed glioblastoma: a phase Ib trial. [PDF]

Nat Commun
Zhang Y, Chi X, Liu K, Ma Y, Zhang S, Ma X, Sun S, Zhang Y, Zhang K, Huang N, Cheng X, Ji N.   +11 more
europepmc   +1 more source

Challenges in Neoantigen-Directed Therapeutics

Cancer Cell, 2023
A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a promising strategy that aims at targeting the host's immune response against tumor-specific antigens, thereby eradicating cancer cells.
Lien Lybaert, Luc Dirix
exaly   +7 more sources

Transcriptomic Profiles of Neoantigen-Reactive T Cells in Human Gastrointestinal Cancers

Cancer Cell, 2022
Tumor-infiltrating neoantigen-reactive T cells can mediate regression of metastatic gastrointestinal cancers yet remain poorly characterized. We performed immunological screening against personalized neoantigens in combination with single-cell RNA ...
Venkatesh Rajamanickam, Eric Tran, Brian D Piening   +2 more
exaly   +2 more sources

Current Trends in Neoantigen-Based Cancer Vaccines

Pharmaceuticals, 2023
Cancer immunotherapies are treatments that use drugs or cells to activate patients’ own immune systems against cancer cells. Among them, cancer vaccines have recently been rapidly developed.
Che-Mai Chang, Wan-Hsuan Chou, Chin-Lin Guo   +2 more
exaly   +2 more sources