Results 221 to 230 of about 25,910 (264)
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Annual Review of Immunology, 2019
Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell–based immune system frequently responds to the neoantigens that arise as a consequence of this DNA damage. Furthermore, recognition of neoantigens appears an important driver of the clinical activity of both T cell checkpoint ...
Ton N, Schumacher +2 more
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Malignant transformation of cells depends on accumulation of DNA damage. Over the past years we have learned that the T cell–based immune system frequently responds to the neoantigens that arise as a consequence of this DNA damage. Furthermore, recognition of neoantigens appears an important driver of the clinical activity of both T cell checkpoint ...
Ton N, Schumacher +2 more
openaire +2 more sources
Neoantigens in cancer immunotherapy
Science, 2015The clinical relevance of T cells in the control of a diverse set of human cancers is now beyond doubt. However, the nature of the antigens that allow the immune system to distinguish cancer cells from noncancer cells has long remained obscure. Recent technological innovations have made it possible to dissect the immune response to patient-specific ...
Ton N, Schumacher, Robert D, Schreiber
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Neoantigens in osteoarthritic cartilage
Current Opinion in Rheumatology, 2004Osteoarthritis has been considered a degenerative disease. However, recent evidence supports involvement of immunologic mechanisms in this pathophysiology: for example, inflammation of synovial tissue is observed in osteoarthritis. In osteoarthritis, the proinflammatory cytokine interleukin-1, which is produced by activated synoviocytes and mononuclear
Tomohiro, Kato +3 more
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Neoantigens Associated with Halothane Hepatitis
Drug Metabolism Reviews, 1989(1989). Neoantigens Associated with Halothane Hepatitis. Drug Metabolism Reviews: Vol. 20, No. 2-4, pp. 203-217.
L R, Pohl +4 more
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Medical Oncology
Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide. Conventional therapeutic modalities-such as surgery, chemotherapy, and radiotherapy-yield suboptimal outcomes in advanced or recurrent disease, while immune checkpoint inhibitors demonstrate durable clinical benefit almost exclusively in the microsatellite ...
Na, Wang +5 more
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Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide. Conventional therapeutic modalities-such as surgery, chemotherapy, and radiotherapy-yield suboptimal outcomes in advanced or recurrent disease, while immune checkpoint inhibitors demonstrate durable clinical benefit almost exclusively in the microsatellite ...
Na, Wang +5 more
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Targeting Neoantigens for Personalised Immunotherapy
BioDrugs, 2018This review discusses the rapidly evolving field of immunotherapy research, focusing on the types of cancer antigens that can be recognised by the immune system and potential methods by which neoantigens can be exploited clinically to successfully target and clear tumour cells.
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Neoantigen Vaccines in Cancer Prevention
The Cancer JournalRecent advances in cancer immunotherapy have established neoantigen-based vaccines as a promising approach to cancer prevention. Unlike tumor-associated antigens, neoantigens originate exclusively from somatic mutations, thus enabling tumor-specific targeting without harm to normal tissues.
Abel Martel-Martel +2 more
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