Results 41 to 50 of about 30,793 (265)

Sources of Cancer Neoantigens beyond Single-Nucleotide Variants

, 2022
The success of checkpoint blockade therapy against cancer has unequivocally shown that cancer cells can be effectively recognized by the immune system and eliminated. However, the identity of the cancer antigens that elicit protective immunity remains to
Lélia Delamarre, Delamarre, Lélia, Hoshyar, Reyhane, Reyhane Hoshyar, Aude-Hélène Capietto, Capietto, Aude-Hélène   +5 more
core   +1 more source

Advances in identification and selection of personalized neoantigen/T-cell pairs for autologous adoptive T cell therapies

OncoImmunology, 2021
Based on the success of tumor-infiltrating lymphocytes (TIL)-based therapies, personalized adoptive cell therapies (ACT) targeting neoantigens have the potential to become a disruptive technology and lead to highly effective treatments for cancer ...
Florian Kast, Christian Klein, Pablo Umaña, Alena Gros, Stephan Gasser   +4 more
doaj   +1 more source

NeoHunter: Flexible software for systematically detecting neoantigens from sequencing data

Quantitative Biology
Complicated molecular alterations in tumors generate various mutant peptides. Some of these mutant peptides can be presented to the cell surface and then elicit immune responses, and such mutant peptides are called neoantigens.
Tianxing Ma, Zetong Zhao, Haochen Li, Lei Wei, Xuegong Zhang   +4 more
doaj   +1 more source

Structural changes from wild-type define tumor-rejecting neoantigens

Journal for ImmunoTherapy of Cancer
Background Challenges in predicting which neoantigens mediate tumor rejection limit the efficacy of neoantigen vaccines to treat cancers, especially for cancers with a high mutational burden like cutaneous squamous cell carcinoma (cSCC).
Xing Li, Tao Ma, Anngela C Adams, Anne M Macy, Elizabeth S Borden, Lauren M Herrmann, Kenneth H Buetow, Melissa A Wilson, Denise J Roe, Karen Taraszka Hastings, Chad A Brambley, Sandip Ashok Sonar, Alysia Hughes, Aaron R Mangold, Janko Z Nikolich, Brian M Baker   +15 more
doaj   +1 more source

A novel neoantigen discovery approach based on chromatin high order conformation

BMC Medical Genomics, 2020
Background High-throughput sequencing technology has yielded reliable and ultra-fast sequencing for DNA and RNA. For tumor cells of cancer patients, when combining the results of DNA and RNA sequencing, one can identify potential neoantigens that ...
Yi Shi, Mingxuan Zhang, Luming Meng, Xianbin Su, Xueying Shang, Zehua Guo, Qingjiao Li, Mengna Lin, Xin Zou, Qing Luo, Yaoliang Yu, Yanting Wu, Lintai Da, Tom Weidong Cai, Guang He, Ze-Guang Han   +15 more
doaj   +1 more source

Tumor Neoantigens Derived from RNA Sequencing Analysis

, 2017
Successful treatment of cancers with Immune Checkpoint Inhibitors (ICIs) has been associated with the mutational load of tumors. The biological rationale for this association between mutational load and ICI response is that neoantigens are generated by ...
Shaojun Tang, Rapisuwon, Suthee, Madhavan, Subha, Suthee Rapisuwon, Subha Madhavan, Tang, Shaojun, Anton Wellstein, Wellstein, Anton   +7 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Somatic Mutations in DNA Mismatch Repair Genes, Mutation Rate and Neoantigen Load in Acute Lymphoblastic Leukemia

Pharmaceuticals
Background/Objectives: During cancer development, tumor cells accumulate somatic mutations, which could generate tumor-specific neoantigens. The aberrant protein can be recognized by the immune system as no-self, triggering an immune response against ...
Diana Karen Mendiola-Soto, Laura Gómez-Romero, Juan Carlos Núñez-Enríquez, Janet Flores-Lujano, Elva Jiménez-Hernández, Aurora Medina-Sansón, Vilma Carolina Bekker-Méndez, Minerva Mata-Rocha, María Luisa Pérez-Saldívar, David Aldebarán Duarte-Rodríguez, José Refugio Torres-Nava, José Gabriel Peñaloza-González, Luz Victoria Flores-Villegas, Raquel Amador-Sánchez, Martha Margarita Velázquez-Aviña, Jorge Alfonso Martín-Trejo, Laura Elizabeth Merino-Pasaye, Karina Anastacia Solís-Labastida, Rosa Martha Espinosa-Elizondo, Carlos Jhovani Pérez-Amado, Didier Ismael May-Hau, Omar Alejandro Sepúlveda-Robles, Haydee Rosas-Vargas, Juan Manuel Mejía-Aranguré, Silvia Jiménez-Morales   +24 more
doaj   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Integrated Profiling Uncovers Lymphoma Immunoglobulin Neoantigens

, 2017
CD4+ T cells specific for immunoglobulin-derived neoantigens target autologous lymphoma cells.

core   +1 more source