Results 31 to 40 of about 30,793 (265)

TruNeo: an integrated pipeline improves personalized true tumor neoantigen identification

BMC Bioinformatics, 2020
Background Neoantigen-based personal vaccines and adoptive T cell immunotherapy have shown high efficacy as a cancer treatment in clinical trials. Algorithms for the accurate prediction of neoantigens have played a pivotal role in such studies.
Yunxia Tang, Yu Wang, Jiaqian Wang, Miao Li, Linmin Peng, Guochao Wei, Yixing Zhang, Jin Li, Zhibo Gao   +8 more
doaj   +1 more source

Identification of a CD8+ T-cell response to a predicted neoantigen in malignant mesothelioma

OncoImmunology, 2020
Neoantigens present unique and specific targets for personalized cancer immunotherapy strategies. Given the low mutational burden yet immunotherapy responsiveness of malignant mesothelioma (MM) when compared to other carcinogen-induced malignancies ...
Sophie Sneddon, Craig M. Rive, Shaokang Ma, Ian M. Dick, Richard J. N. Allcock, Scott D. Brown, Robert A. Holt, Mark Watson, Shay Leary, Y. C. Gary Lee, Bruce W. S. Robinson, Jenette Creaney   +11 more
doaj   +1 more source

Neoantigens in precision cancer immunotherapy: from identification to clinical applications

Chinese Medical Journal, 2022
. Immunotherapies targeting cancer neoantigens are safe, effective, and precise. Neoantigens can be identified mainly by genomic techniques such as next-generation sequencing and high-throughput single-cell sequencing; proteomic techniques such as mass ...
Qiao Zhang, Qingzhu Jia, Jing Zhang, Bo Zhu, Peifang Wei   +4 more
doaj   +1 more source

Editorial: The Clinical Application of Neoantigens [PDF]

Frontiers in Immunology, 2022
Editorial on the Research Topic The Clinical Application of ...
Jian-Guo Zhou, Jian-Guo Zhou, Jian-Guo Zhou, Jian-Guo Zhou, Zhenyu Ding, Huashan Shi, Min Cheng   +6 more
openaire   +3 more sources

Neoantigens and their clinical applications in human gastrointestinal cancers

World Journal of Surgical Oncology, 2022
Background Tumor-specific neoantigens are ideal targets for cancer immunotherapy. As research findings have proved, neoantigen-specific T cell activity is immunotherapy’s most important determinant. Main text There is sufficient evidence showing the role
Zahra Shokati Eshkiki, Shahram Agah, Seidamir Pasha Tabaeian, Meghdad Sedaghat, Fatemeh Dana, Atefeh Talebi, Abolfazl Akbari   +6 more
doaj   +1 more source

Development of neoantigens: from identification in cancer cells to application in cancer vaccines

, 2021
Introduction: The discovery of neoantigens as mutated proteins specifically expressed in tumor cells but not in normal cells has led to improved cancer vaccines.
Boroujeni, Marziyeh Borjian, Yazdani, Elnaz, Hamblin, Michael R., Roozbahani moghaddam, Parichehr, Akbari, Maryam, Adelian, Samaneh, Ebrahimi, Nasim, Ahmadi, Amirhossein, Ghanaatian, Masoud, Borjian Boroujeni, Marziyeh, Moghaddam, Parichehr Roozbahani, Maryam Akbari, Masoud Ghanaatian, Marziyeh Borjian Boroujeni, Parichehr Roozbahani moghaddam, Samaneh Adelian, Nasim Ebrahimi, Michael R. Hamblin, Amirhossein Ahmadi, Elnaz Yazdani   +19 more
core   +1 more source

Neoantigens:

, 2022
The expression of non-synonymous mutations can result in the production of neoantigens, which are tumor-specific antigens. Neoantigens, or tumor-specific antigens, can be produced as a result of the expression of non-synonymous mutations.
openaire   +1 more source

Evolutionary dynamics of neoantigens in growing tumors [PDF]

, 2020
Cancers accumulate mutations that lead to neoantigens, novel peptides that elicit an immune response, and consequently undergo evolutionary selection.
Werner, B, Anderson, ARA, Zapata, L, Williams, MJ, Househam, J, Robertson-Tessi, M, Gatenbee, C, Cross, WCH, Graham, TA, Sottoriva, A, Barnes, CP, Schenck, RO, Lakatos, E   +12 more
core   +2 more sources

The Value of Microbes in Cancer Neoantigen Immunotherapy

Pharmaceutics, 2023
Tumor neoantigens are widely used in cancer immunotherapy, and a growing body of research suggests that microbes play an important role in these neoantigen-based immunotherapeutic processes.
Junrui Tian, Jian Ma
doaj   +1 more source

Challenges in neoantigen-directed therapeutics

Cancer Cell, 2023
A fundamental prerequisite for the efficacy of cancer immunotherapy is the presence of functional, antigen-specific T cells within the tumor. Neoantigen-directed therapy is a promising strategy that aims at targeting the host's immune response against tumor-specific antigens, thereby eradicating cancer cells.
Lien Lybaert, Steve Lefever, Bruno Fant, Evelien Smits, Bruno De Geest, Karine Breckpot, Luc Dirix, Steven A. Feldman, Wim van Criekinge, Kris Thielemans, Sjoerd H. van der Burg, Patrick A. Ott, Cedric Bogaert   +12 more
openaire   +4 more sources