Results 11 to 20 of about 30,793 (265)
Frontiers in ImmunologyBackgroundNeoantigens, mutated tumour-specific antigens, are key targets of anti-tumour immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to designing neoantigen-directed therapy.
Christopher C. T. Sng +7 more
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The Clinical Application of Neoantigens in Esophageal Cancer [PDF]
Frontiers in Oncology, 2021 Esophageal cancer (EC) is a common malignant tumor with poor prognosis, and current treatments for patients with advanced EC remain unsatisfactory. Recently, immunotherapy has been recognized as a new and promising approach for various tumors.
Yi-Min Gu +3 more
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Cancer neoantigens and immunogenicity: mutation position matters
Molecular & Cellular Oncology, 2020 Cancer mutations can elicit protective immunity. Computational methods are critical for selecting these neoantigens for immunotherapy. While significant progress has been made in the field in predicting peptide presentation, our understanding of which ...
Aude-Hélène Capietto +2 more
doaj +2 more sources
The landscape of neoantigens and its clinical applications: From immunobiology to cancer vaccines
Current Research in BiotechnologySince millions of cancer-related deaths and diagnoses exist yearly, malignant tumors are a primary worldwide health concern. A promising method for treating cancer is tumor immunotherapy, which focuses on neoantigens.
Chiranjib Chakraborty +4 more
doaj +2 more sources
Neoantigen Controversies [PDF]
Annual Review of Biomedical Data Science, 2021 Next-generation sequencing technologies have revolutionized our ability to catalog the landscape of somatic mutations in tumor genomes. These mutations can sometimes create so-called neoantigens, which allow the immune system to detect and eliminate tumor cells.
Castro, Andrea +2 more
openaire +3 more sources
Overcoming Drug Resistance by Paclitaxel Resistance in Triple-Negative Breast Cancer. [PDF]
Adv Sci (Weinh)In the murine triple‐negative breast cancer (TNBC) model, chemotherapy effectively increases tumor neoantigen burden (TNB). Here, the study constructs a liposomal nanovaccine using antigens derived from in vitro chemotherapy‐treated paclitaxel‐resistant TNBC 4T1 cells.
Chen B +10 more
europepmc +2 more sources
NeoFox: annotating neoantigen candidates with neoantigen features
Bioinformatics, 2021 Abstract Summary The detection and prediction of true neoantigens is of great importance for the field of cancer immunotherapy. Wesearched the literature for proposed neoantigen features and integrated them into a toolbox called NEOantigen Feature toolbOX (NeoFox).
Franziska Lang +4 more
openaire +3 more sources
Identification of neoantigens in esophageal adenocarcinoma [PDF]
Immunology, 2022 Abstract Esophageal adenocarcinoma (EAC) has a relatively poor long-term survival and limited treatment options. Promising targets for immunotherapy are short peptide neoantigens containing tumor mutations, presented to cytotoxic T-cells by human leukocyte antigen molecules (HLA).
Ben Nicholas +10 more
openaire +3 more sources
Neoantigens: The Novel Precision Cancer Immunotherapy
Biologics, 2023 The past few decades have witnessed the remarkable progress of cancer immunotherapy. Neoantigens, also known as tumor-specific antigens, are novel antigens originating from tumor-specific alterations such as genomic mutations, dysregulated RNA splicing ...
Tiantian Zhang, Esaw Kurban, Zhe Wang
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Frontiers in Immunology, 2022 Neoantigens are widely reported to induce T-cell response and lead to tumor regression, indicating a promising potential to immunotherapy. Previously, we constructed an open-access database, i.e., dbPepNeo, providing a systematic resource for human tumor
Manman Lu +19 more
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