Results 1 to 10 of about 30,793 (265)

Shared Neoantigens for Cancer Immunotherapy

Molecular Therapy Oncology
Exploration of neoantigens holds the potential to be productive in immuno-oncotherapy. Among tumor-specific antigens, neoantigens result from genetic instability that gives rise to non-synonymous somatic mutations, highly specific to tumor cells.
Laleh Majlessi, Pierre Charneau, Pierre Authié   +2 more
exaly   +7 more sources

Neoantigens in Hematologic Malignancies

Frontiers in Immunology, 2020
T cell cancer neoantigens are created from peptides derived from cancer-specific aberrant proteins, such as mutated and fusion proteins, presented in complex with human leukocyte antigens on the cancer cell surface.
Melinda A. Biernacki, Melinda A. Biernacki, Marie Bleakley, Marie Bleakley   +3 more
doaj   +3 more sources

Proteomic and proteogenomic identification of targetable T-cell antigens in multiple myeloma [PDF]

Blood Advances
: Multiple myeloma (MM) accounts for ∼12% of all hematologic malignancies and remains incurable despite therapeutic advances. Targeting tumor-associated antigens (TAAs) and tumor-specific neoantigens presented on HLA molecules by vaccination or T-cell ...
Gabriela Zuleger, Niklas de Andrade Krätzig, Piero Giansanti, Nikos Darzentas, Mariagiovanna Barresi, Antonia Teske, Riccardo Trozzo, Sarah Lutzenberger, Stefan Forster, Alice Descoeudres, Arthur Wagner, Hanno S. Meyer, Monika Hammel, Chien-Yun Lee, Michael Hiltensperger, Dirk H. Busch, Bernhard Meyer, Stefan Canzar, Judith S. Hecker, Monika Brüggemann, Roland Rad, Eva Bräunlein, Angela M. Krackhardt   +22 more
doaj   +2 more sources

Cancer Neoantigens: Challenges and Future Directions for Prediction, Prioritization, and Validation

Frontiers in Oncology, 2022
Prioritization of immunogenic neoantigens is key to enhancing cancer immunotherapy through the development of personalized vaccines, adoptive T cell therapy, and the prediction of response to immune checkpoint inhibition.
Melissa A. Wilson Sayres, Elizabeth S Borden, Karen Hastings   +2 more
exaly   +3 more sources

Neoantigens: Promising Targets for Cancer Therapy

Signal Transduction and Targeted Therapy, 2023
Recent advances in neoantigen research have accelerated the development and regulatory approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and antibody-based therapies, especially for solid tumors.
Guobo Shen, Canhua Huang, Li Fu
exaly   +2 more sources

Identification of Shared Neoantigens Derived From Frameshift Mutations in the APC Gene

Frontiers in Immunology
Recent advances of cancer immunotherapy have identified neoantigens as essential targets for personalized treatments. However, since neoantigens are generally unique in individual cancers, neoantigen therapies that are more broadly applicable are eagerly
Toshihiro Tanaka, Kazuma Kiyotani, Saki Matsumoto   +2 more
exaly   +3 more sources

Utilizing immunogenomic approaches to prioritize targetable neoantigens for personalized cancer immunotherapy

Frontiers in Immunology, 2023
Advancements in sequencing technologies and bioinformatics algorithms have expanded our ability to identify tumor-specific somatic mutation-derived antigens (neoantigens).
Ravi K. Shah, Erin Cygan, Tanya Kozlik, Alfredo Colina, Anthony E. Zamora, Anthony E. Zamora   +5 more
doaj   +1 more source

Dominant neoantigen verification in hepatocellular carcinoma by a single-plasmid system coexpressing patient HLA and antigen

Journal for ImmunoTherapy of Cancer, 2023
Background Previous studies confirmed that most neoantigens predicted by algorithms do not work in clinical practice, and experimental validations remain indispensable for confirming immunogenic neoantigens.
Jie Gao, Yao Yang, Pu Chen, Dongbo Chen, Dechao Bu, Wanying Qin, Kangjian Deng, Liying Ren, Shaoping She, Wentao Xu, Xingwang Xie, Weijia Liao, Hongsong Chen   +12 more
doaj   +1 more source

A Comprehensive Survey of Genomic Mutations in Breast Cancer Reveals Recurrent Neoantigens as Potential Therapeutic Targets

Frontiers in Oncology, 2022
Neoantigens are mutated antigens specifically generated by cancer cells but absent in normal cells. With high specificity and immunogenicity, neoantigens are considered as an ideal target for immunotherapy.
Si Zhou, Songming Liu, Lijian Zhao, Hai-Xi Sun   +3 more
doaj   +1 more source

Characterization of Somatic Mutations That Affect Neoantigens in Non-Small Cell Lung Cancer

Frontiers in Immunology, 2022
PurposeImmune checkpoint inhibitors (ICIs) have recently emerged as an important option for treating patients with advanced non-small cell lung cancer (NSCLC).
Hongge Liang, Hongge Liang, Yan Xu, Minjiang Chen, Jing Zhao, Wei Zhong, Xiaoyan Liu, Xiaoxing Gao, Shanqing Li, Ji Li, Chao Guo, He Jia, Mengzhao Wang   +12 more
doaj   +1 more source