Results 191 to 200 of about 115,708 (268)

Midbrain PAG Astrocytes Modulate Mouse Defensive and Panic‐Like Behaviors

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Astrocytes in the midbrain periaqueductal gray (PAG) dynamically encode threat intensity and shape defensive action selection in mice. Real‐time Ca2+ imaging reveals robust astrocytic activation during predator odor and CO2 exposure. Aberrant astrocytic Ca2+ overactivation disrupts goal‐directed escape, biases behavior toward freezing, and induces ...
Ellane Barcelon, Kyungchul Noh, Minkyu Hwang, Yoon‐Jung Kim, Unjin Lee, Yeon Joo Ryu, Je‐Kyung Ryu, Sang Beom Jun, Se‐Young Choi, Woo‐Hyun Cho, Sung Joong Lee   +10 more
wiley   +1 more source

Glial cytokine modulation improves sleep and circadian disruption in female SAA knock‐in mice of Alzheimer's‐related pathology

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Sleep and circadian disturbances are early Alzheimer's disease (AD) features, yet mechanisms linking amyloid pathology, neuroinflammation, and sex differences remain unclear. METHODS We longitudinally assessed sleep, circadian rhythms, and cognition in female and male hAPPSAA knock‐in and control mice from 2 to 19 months using ...
Teresa Macheda, Margaret R. Hawkins, Carrie E. Johnson, Madison G. Lapid, Haleigh R. Whitlock, Savannah M. Shepard, MaKayla F. Cox, Kelly N. Roberts, Leke Bytyqi, Heather M. Hash, Omar A Abou El‐Ezz, Mohammed Abou El‐Ezz, Katherina Kohler, Sridhar Sunderam, Bruce F. O'Hara, Linda J. Van Eldik, Michael P. Murphy, Marilyn J. Duncan, Adam D. Bachstetter   +18 more
wiley   +1 more source

Amyloid spatial extent with florbetapir-PET for early detection of preclinical Alzheimer's disease. [PDF]

J Prev Alzheimers Dis
Thibault EG, Del Carmen Montenegro G, Becker JA, Price JC, Healy BC, Hanseeuw BJ, Buckley RF, Jacobs HIL, Properzi MJ, Sperling RA, Johnson KA, Farrell ME.   +11 more
europepmc   +1 more source

Florzolotau (18F) retention is linked to neuropsychological performance in tauopathy

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Florzolotau (18F) positron emission tomography visualizes three‐ and four‐repeat tau isoforms. We aimed to evaluate correlation of tau tracer retention with neuropsychological performance across the Alzheimer's disease (AD) continuum and non‐AD tauopathies.
Atsushi Shimizu, Yu Iwabuchi, Shogyoku Bun, Memi Watanabe, Masahito Kubota, Sho Shimohama, Toshiki Tezuka, Keisuke Takahata, Hajime Tabuchi, Morinobu Seki, Yuki Momota, Yasuharu Yamamoto, Ryo Shikimoto, Yu Mimura, Shin Kurose, Ryosuke Sakurai, Toshiki Takayama, Yuka Hoshino, Takayuki Hoshino, Natsumi Suzuki, Ayaka Morimoto, Azusa Osumi, Masaru Mimura, Masahiro Jinzaki, Daisuke Ito   +24 more
wiley   +1 more source

Modeling small vessel disease burden and vascular dementia likelihood from NACC data

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Cerebrovascular pathology contributes to dementia but lacks standardized quantification for multicenter datasets. We developed harmonized indices to quantify small vessel disease (SVD) and vascular cognitive impairment (VCI) likelihood using National Alzheimer's Coordinating Center Neuropathology 11 data.
Angelique D. Gonzalez, Ali Ghaseminejad‐Bandpey, Sudha Seshadri, Shahroo Etemadmoghadam, Margaret E. Flanagan   +4 more
wiley   +1 more source

Serum p‐tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder

Annals of Neurology, Volume 99, Issue 4, Page 912-921, April 2026.
Objective Assess the performance of serum phosphorylated tau 217 (p‐tau217) and neurofilament light chain (NfL) in predicting risk of cognitive impairment or phenoconversion to dementia in individuals with iRBD. Methods We measured serum p‐tau217 and NfL levels by electrochemiluminescence across 4 polysomnographically confirmed iRBD cohorts (n = 300 ...
Shijun Yan, Anis Sahoo, Tanja Zerenner, Kenneth Marek, Michael Sommerauer, Wolfgang Oertel, Michele T. Hu, George K. Tofaris   +7 more
wiley   +1 more source

Recurrent neonatal seizures increase tonic inhibition and respond to enhancers of δ-containing GABAA receptors. [PDF]

JCI Insight
Liddiard GT, Buchanan GF, Schultz ML, Glykys J.   +3 more
europepmc   +1 more source

The Phenotypic Spectrum of Sporadic Creutzfeldt‐Jakob Disease Cortical Subtype

Annals of Neurology, Volume 99, Issue 4, Page 883-896, April 2026.
Objective The objective of this study was to characterize the phenotypic spectrum of the rare sporadic Creutzfeldt‐Jakob disease cortical subtype (sCJDMM/MV2C) in a large multicentric autopsy cohort. Methods We evaluated clinical histories, biofluid markers, brain diffusion‐weighted (DW)‐magnetic resonance imaging (MRI), and electroencephalogram (EEG ...
Simone Baiardi, Claudia Marina Vargiu, Brian S. Appleby, Marcelo Barria, Giuseppe Mario Bentivenga, Ignazio Calì, Benedetta Carlà, Mark Cohen, Armin Giese, Jochen Herms, Aino‐Minerva Kortelainen, Anna Ladogana, Angela Mammana, Diane Ritchie, Otto Windl, Sabina Capellari, Piero Parchi   +16 more
wiley   +1 more source

But how does it smell? An investigation of olfactory bulb size among living and fossil primates and other euarchontoglirans

The Anatomical Record, Volume 309, Issue 4, Page 1037-1060, April 2026.
Analysis of cranial endocast data of 181 extant and 41 fossil species from Euarchontoglires shows that there was a reduction in olfactory bulb size in Crown Primates, but that there were also subsequent reductions in various other primate clades (Anthropoidea, Catarrhini, Platyrrhini, crown Cercopithecoidea, Hominoidea).
Madlen Maryanna Lang, Mary Teresa Silcox, Łucja Fostowicz‐Frelik, Adam Lis, Sergi López‐Torres, Gabriela San Martin‐Flores, Ornella C. Bertrand   +6 more
wiley   +1 more source