Results 91 to 100 of about 24,656 (260)
NSUN2 and m5C decline in URSA villous tissues. Trophoblast Nsun2 ablation disrupts macrophage‐mediated maternal‐fetal tolerance and triggers embryo resorption. Mechanistically, NSUN2‐YBX1 axis stabilizes m5C‐modified TGFB1 mRNA to maintain TGF‐β1 secretion and M2 polarization, and restoring this signaling rescues maternal‐fetal immune tolerance to ...
Xiaoxiao Zhu +10 more
wiley +1 more source
FOXP1 Knockdown Reprograms Th9 CAR‐T Cells to Overcome Antigen Escape
FOXP1 knockdown enhances Th9 CAR‐T cell function by promoting IL‐9 production, effector activation, and reduced exhaustion. Reprogrammed Th9 CAR‐T cells strengthen direct tumor killing and activate endogenous antitumor immunity through dendritic cells and CD8+ T cells, thereby suppressing both antigen‐positive and antigen‐loss tumor growth and ...
Yihan Zhu +14 more
wiley +1 more source
Environmental monitoring networks such as the Integrated Carbon Observation System (ICOS) in Europe, the National Ecological Observatory Network (NEON) in the U.S., or the Terrestrial Ecosystem Research Network (TERN) in Australia deploy different ...
Kaha Mihkel +3 more
doaj +1 more source
While the design economies of Estonia, Latvia, and Lithuania had been closely interconnected under the Soviet occupation, the collapse of the Soviet empire also brought new conditions and possibilities.
Karolina Jakaitė, Triin Jerlei
doaj +1 more source
Intelligent Programmable Membrane Nanosponge for Early Virus Blocking
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen +17 more
wiley +1 more source
Single‐Cell Profiling Reveals Clonally Expanded CX3CR1+ T Cells in Anti‐NMDA Receptor Encephalitis
CX3CR1+ T cells are associated with peripheral and central immune alterations in anti‐NMDA receptor encephalitis (NMDAR‐E). They show potential responsiveness to GluN1 (NR1) peptides, potential interactions with peripheral B cells, clonal expansion, increased CD137/CD154 expression, and inflammatory cytokine production. Their preferential cerebrospinal
Lin Yan +13 more
wiley +1 more source
Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly
LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang +6 more
wiley +1 more source

