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Correction for Wani et al., Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant β ₂ -microglobulin gene

, 2006

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Neonatal Fc receptor antagonist, efgartigimod, for chronic ITP

Japanese Journal of Thrombosis and Hemostasis
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Neonatal Fc Receptor Inhibitor Therapeutics in Neuromuscular Disease.

Journal of Clinical Neuromuscular Disease, 2023
The Neonatal Fc Receptor (FcRn) is integral to a wide variety of processes including IgG recycling, serum albumin turnover, and bacterial opsonization. Thus, targeting FcRn will increase antibody degradation including pathogenic IgGs.
Mustafa Jaffry, D. Menkes, A. Shaikh, Kranthi Mandava, Om Kothari, Kazim Jaffry, N. Souayah   +6 more
semanticscholar   +3 more sources

Targeting neonatal Fc receptor: potential clinical applications in pregnancy

Ultrasound in Obstetrics & Gynecology, 2022
The neonatal Fc receptor (FcRn) plays an important role in the transfer of the immunoglobulin G isotype (IgG) from the mother to the fetus. FcRn expressed on endothelial cells also binds to IgG and albumin, regulating the circulating half‐lives of these ...
K. J. Moise, D. Oepkes, E. Lopriore, R. Bredius   +3 more
semanticscholar   +4 more sources

Neonatal Fc Receptor - Biology and Therapeutics.

New England Journal of Medicine
James B. Bussel, D. Cines, Richard S. Blumberg   +2 more
semanticscholar   +5 more sources

FcRn: the neonatal Fc receptor comes of age

Nature Reviews Immunology, 2007
The neonatal Fc receptor for IgG (FcRn) has been well characterized in the transfer of passive humoral immunity from a mother to her fetus. In addition, throughout life, FcRn protects IgG from degradation, thereby explaining the long half-life of this class of antibody in the serum. In recent years, it has become clear that FcRn is expressed in various
D. Roopenian, Shreeram Akilesh
semanticscholar   +3 more sources

Regulation of dendritic cell function by Fc-γ-receptors and the neonatal Fc receptor

Molecular Immunology, 2021
Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among those receptors, Fc receptors (FcRs) are triggered by the Fc region of antibodies produced during adaptive immunity. In this review, the role of FcγR and neonatal Fc receptor (FcRn) in DC immunity will be discussed.
Christophe, Macri, Huw, Morgan, Jose A, Villadangos, Justine D, Mintern   +3 more
openaire   +2 more sources

Neonatal Fc Receptor Inhibition Enables Adeno-Associated Virus Gene Therapy Despite Pre-Existing Humoral Immunity

Human Gene Therapy, 2023
Advances in adeno-associated virus (AAV)-based gene therapy are transforming our ability to treat rare genetic disorders and address other unmet medical needs. However, the natural prevalence of anti-AAV neutralizing antibodies (NAbs) in humans currently
M. Horiuchi, Christian J. Hinderer, Hailey N Shankle, Peter M. Hayashi, Jessica A. Chichester, Casey Kissel, Peter Bell, Cecilia Dyer, James M. Wilson   +8 more
semanticscholar   +1 more source

Neonatal Fc receptor blockade as emerging therapy in diseases with plasma exchange indications

Journal of clinical apheresis, 2023
Neonatal Fc receptor (FcRn) blockade may represent a mechanism similar to plasma exchange (PLEX) in reducing immunoglobulin levels and thus have a broad implication for apheresis practitioners.
Muharrem Yunce, Nakul Katyal, Grace Fortes Monis, S. Muppidi   +3 more
semanticscholar   +1 more source