Results 261 to 270 of about 109,700 (295)

Synonymous nucleotide substitutions in the neonatal Fc receptor

Immunogenetics, 2002
The neonatal Fc receptor (FcRn) is a key receptor involved in the transcytosis of IgG across the maternal-fetal barrier. The level of IgG varies considerably among newborn infants. Since other Fc gamma receptors show single nucleotide functional variants, we determined whether common variant alleles exist for the FcRn.
Carolyn A, Gunraj, Bernard J, Fernandes, Gregory A, Denomme   +2 more
openaire   +2 more sources

Crystal structure of the complex of rat neonatal Fc receptor with Fc

Nature, 1994
The neonatal Fc receptor (FcRn) transports maternal immunoglobulin G (IgG) to the bloodstream of the newborn. FcRn is structurally similar to class I major histocompatibility complex (MHC) molecules, despite differences in the ligands they bind (the Fc portion of IgG and antigenic peptides, respectively).
Burmeister, Wilhelm P., Huber, Andrew H., Bjorkman, Pamela J.   +2 more
openaire   +3 more sources

Multivalent Albumin-Neonatal Fc Receptor Interactions Mediate a Prominent Extension of the Serum Half-Life of a Therapeutic Protein.

Molecular Pharmaceutics, 2021
Human serum albumin (HSA) has been used to extend the serum half-life of therapeutic proteins owing to its exceptionally long serum half-life via the neonatal Fc receptor (FcRn)-mediated recycling mechanism.
Byungseop Yang, Inchan Kwon
semanticscholar   +1 more source

Fc engineered anti‐virus therapeutic human IgG1 expressed in plants with altered binding to the neonatal Fc receptor

Biotechnology Journal
Production of therapeutic monoclonal antibody (mAb) in transgenic plants has several advantages such as large‐scale production and the absence of pathogenic animal contaminants.
Sol Park, Yoonji Lee, Hyunjoo Hwang, Jeong Hwan Lee, Y. Kang, Yerin Kim, Caiquan Jin, Hyun Joo An, Y. Oh, Peter Hinterdorfer, Eunhye Kim, Sun Choi, Kisung Ko   +12 more
semanticscholar   +1 more source

Polymorphisms of Neonatal Fc Receptor in Cynomolgus and Rhesus Macaques

Drug Metabolism and Pharmacokinetics, 2014
Neonatal Fc receptor (FcRn), a heterodimer of MHC class I-like protein and β2-microglobulin, encoded by FCGRT and B2M, respectively, is important for recycling immunoglobulin G (IgG) antibodies by binding with the Fc region of IgG. Cynomolgus macaques are important animal species used in the evaluation of therapeutic antibodies, largely due to sequence
Yasuhiro, Uno, Masahiro, Utoh, Kazuhide, Iwasaki   +2 more
openaire   +2 more sources

Isolation of the gene encoding the bovine neonatal Fc receptor

Veterinary Immunology and Immunopathology, 2005
The role of an IgG-Fc receptor (FcRn) that resembles a class I MHC Ag in transporting IgGs through epithelial cells was recently shown in selected species. Here we report our preliminary characterization of a clone encoding the alpha chain of the bovine FcRn from a BAC library.
Márton, Doleschall, Yaofeng, Zhao, Balázs, Mayer, Lennart, Hammarström, Imre, Kacskovics   +4 more
openaire   +2 more sources

The neonatal Fc receptor and DPP4 are human astrovirus receptors

AbstractHuman astroviruses (HAstV) are major global causes of gastroenteritis, but little is known about host factors required for their cellular entry. Here, we utilized complementary CRISPR-Cas9-based knockout and activation screening approaches and identified neonatal Fc receptor (FcRn) and dipeptidyl-peptidase IV (DPP4) as entry factors for HAstV ...
Harshad, Ingle, Jerome M, Molleston, Paige D, Hall, Duyen, Bui, Leran, Wang, Lynne, Foster, Avan, Antia, Siyuan, Ding, Sanghyun, Lee, Daved H, Fremont, Megan T, Baldridge   +10 more
openaire   +2 more sources

The neonatal Fc receptor (FcRn) expression in the human skin

Virchows Archiv, 2007
The neonatal Fc receptor, FcRn, has a wide expression within the human body, including adult cells; however, it is not ubiquitously expressed (reviewed in [2]). The receptor is involved both in IgG transcytosis as well as recycling, being able to bind both free and antigen complexed IgG molecules (reviewed in [4]). Cauza et al.
Petru, Cianga, Corina, Cianga, Petru, Plamadeala, Daciana, Branisteanu, Eugen, Carasevici   +4 more
openaire   +2 more sources

Efficacy and safety of the neonatal Fc receptor inhibitor efgartigimod in adults with primary immune thrombocytopenia (ADVANCE IV): a multicentre, randomised, placebo-controlled, phase 3 trial

The Lancet, 2023
C. Broome, Vickie Mcdonald, Yoshitaka Miyakawa, M. Carpenedo, D. Kuter, H. Al-Samkari, J. Bussel, Marie Godar, J. Ayguasanosa, K. D. Beuf, Francesco Rodeghiero, Marc Michel, A. Newland, M. Fillitz, P. Knoebl, Stefaan Meers, Ismail Mohamad Amine, Jaromír Gumulec, A. Hluší, Jiří Mayer, P. Quittet, J. Viallard, Magdana Betaneli, Irine Datikashvili-David, G. Iosava, Levan Makhaldiani, László Rejtő, Nino Sharashenidze, Stefanie Groepper, Alexander Röth, Aryan Hamed, Á. Illés, A. Artoni, M. Bocchia, B. Gamberi, A. Borchiellini, Esther Natalie Oliva, Andrea Patriarca, Simona Tomassetti, Kiyoshi Ando, Hiroshi Handa, S. Katsutani, K. Nishiwaki, Shoko Ito, Tomoki Ito, Fransien de Boer, A. J. G. Jansen, H. Ciepłuch, S. Fornagiel, S. Grosicki, M. Soroka-Wojtaszko, J. Treliński, Bulat A. Bakirov, E. Borisenkova, E. Volodicheva, Yuri Shatokhin, A. Proydakov, Maria Aranzazu Alonso, M. Mingot-Castellano, B. Sánchez-González, David Valcárcel Ferreiras, M. Aylı, T. Hacıbekiroğlu, A. Demir, M. Nalçacı, Mehmet Sonmez, A. Tombak, S. Toprak, B. Turgut, Filiz Vural, M. Yağcı, Fevzi Altuntaş, Mehmet Turgut, Emin Kaya, Nataliya Romanyuk, Syed Rashid Saeed Kazmi, C. Broome, S. Cataland, Ketan Doshi, Steven R. Lentz, M. Boxer, Richard Rosenberg   +81 more
semanticscholar   +1 more source

[Neonatal Fc receptor, key control of immunoglobulins biodistribution].

Medecine sciences : M/S, 2010
In 1969, Brambell, while studying the long serum half-life of IgG and their ability to cross the materno-foetal barrier, attributed these two properties to the existence of a specific Fc receptor, which was later denominated FcRn for neonatal Fc receptor. The resolution of its structure revealed that it is a MHC class-I-like molecule.
Charlotte, Magdelaine-Beuzelin, Marc, Ohresser, Hervé, Watier   +2 more
openaire   +1 more source