Results 181 to 190 of about 7,511 (210)
A Predictive Model of Therapeutic Monoclonal Antibody Dynamics and Regulation by the Neonatal Fc Receptor (FcRn) [PDF]
Annals of Biomedical Engineering, 2005 We constructed a novel physiologically-based pharmacokinetic (PBPK) model for predicting interactions between the neonatal Fc receptor (FcRn) and anti-carcinoembryonic antigen (CEA) monoclonal antibodies (mAbs) with varying affinity for FcRn. Our new model, an integration and extension of several previously published models, includes aspects of mAb ...
Gregory Z. Ferl +2 more
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Localization of the human neonatal Fc receptor (FcRn) in human nasal epithelium
Protoplasma, 2015The airway epithelium is a central player in the defense against pathogens including efficient mucociliary clearance and secretion of immunoglobulins, mainly polymeric IgA, but also IgG. Pulmonary administration of therapeutic antibodies on one hand, and intranasal immunization on the other, are powerful tools to treat airway infections. In either case,
Renate Fuchs +4 more
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Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering
Journal of Drug Targeting, 2014The biomedical applications of antibodies as prophylactics, therapeutics and diagnostics are developing rapidly. Neonatal Fc receptor (FcRn) is a major IgG Fc receptor capable of facilitating the translocation of IgG. FcRn can protect IgG from intracellular catabolism, thereby increasing its half-life. In recent decade, the interaction between FcRn and
Zehua Tian +3 more
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Bioorganic & Medicinal Chemistry Letters, 2011
Peptides targeting the human neonatal Fc receptor (FcRn) were conjugated to poly(ethylene glycol) (PEG) polymers to study their effect on inhibition of the IgG:FcRn protein-protein interaction both in vitro and in mice. Both linear (5-40kDa) and branched (20, 40kDa) PEG aldehydes were conjugated to an amine-containing linker of a homodimeric anti-FcRn ...
Todd Hoehn +3 more
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Peptides targeting the human neonatal Fc receptor (FcRn) were conjugated to poly(ethylene glycol) (PEG) polymers to study their effect on inhibition of the IgG:FcRn protein-protein interaction both in vitro and in mice. Both linear (5-40kDa) and branched (20, 40kDa) PEG aldehydes were conjugated to an amine-containing linker of a homodimeric anti-FcRn ...
Todd Hoehn +3 more
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Regulation of Immunological Responses by the Neonatal Fc Receptor for IgG, FcRn
2013Immunoglobulins (Ig) are the hallmark of the humoral immune system and can be found, in varying concentrations, in all tissues of the body as well as throughout the circulatory system. Of the various isotypes, IgG is by far the most abundant in serum due to its extremely long half-life of 7–23 days.
Timo Rath +2 more
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Human Immunology, 2011
The neonatal Fc receptor (FcRn) was demonstrated to play a role both in the recycling and thus the protection of immunoglobulin G (IgG) from catabolism and in the maternal-fetal transfer of IgG. The expression of this particular receptor was evidenced in a variety of cell types, but the endothelial cell was considered the main cell able to perform both
Petru Plamadeala +3 more
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The neonatal Fc receptor (FcRn) was demonstrated to play a role both in the recycling and thus the protection of immunoglobulin G (IgG) from catabolism and in the maternal-fetal transfer of IgG. The expression of this particular receptor was evidenced in a variety of cell types, but the endothelial cell was considered the main cell able to perform both
Petru Plamadeala +3 more
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Acta Histochemica, 2010
Although a marginal placental transfer of maternal immunoglobulin (Ig) has been demonstrated in buffalo, the colostrum still provides the main source of immune components and nutrients to neonate buffalo calves. The neonatal Fc receptor (FcRn) transports maternal Ig across the gut wall and is involved in the transport of IgG in the mammary gland.
Mohamed Kassab +4 more
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Although a marginal placental transfer of maternal immunoglobulin (Ig) has been demonstrated in buffalo, the colostrum still provides the main source of immune components and nutrients to neonate buffalo calves. The neonatal Fc receptor (FcRn) transports maternal Ig across the gut wall and is involved in the transport of IgG in the mammary gland.
Mohamed Kassab +4 more
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Protein Expression and Purification, 2016
Neonatal Fc-receptor (FcRn) with its affinity to immunoglobulin G (IgG) has been the subject of many pharmacokinetic studies in the past century. This protein is well known for its unique feature in maintaining the circulating IgG from degradation in blood plasma. FcRn is formed by non-covalent association between the α-chain with the β-2-microglobulin
Woei Kean Ng +2 more
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Neonatal Fc-receptor (FcRn) with its affinity to immunoglobulin G (IgG) has been the subject of many pharmacokinetic studies in the past century. This protein is well known for its unique feature in maintaining the circulating IgG from degradation in blood plasma. FcRn is formed by non-covalent association between the α-chain with the β-2-microglobulin
Woei Kean Ng +2 more
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Blood, 2010
Abstract Abstract 2529 There are several theories as to the mechanism of intravenous immunoglobulin (IVIg) in the treatment of autoimmune diseases such as immune thrombocytopenia (ITP). One prominent theory involves accelerated pathogenic autoantibody clearance by saturation of the neonatal Fc Receptor (FcRn).
Andrew R. Crow +2 more
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Abstract Abstract 2529 There are several theories as to the mechanism of intravenous immunoglobulin (IVIg) in the treatment of autoimmune diseases such as immune thrombocytopenia (ITP). One prominent theory involves accelerated pathogenic autoantibody clearance by saturation of the neonatal Fc Receptor (FcRn).
Andrew R. Crow +2 more
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BIOTECHNOLOGY: STATE OF THE ART AND PERSPECTIVES, 2020
In this work, the influence of the expression levels of the neonatal Fc receptor (FcRn) on the sensitivity of the human transformed and tumor cells to 15 non-pathogenic strains of human enteroviruses was shown. The Complete inactivation of the neonatal fc receptor gene FCGRT in cells led to loss of the sensitivity to Echoviruses 1, 6, 7, 11, 12, 25, 30,
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In this work, the influence of the expression levels of the neonatal Fc receptor (FcRn) on the sensitivity of the human transformed and tumor cells to 15 non-pathogenic strains of human enteroviruses was shown. The Complete inactivation of the neonatal fc receptor gene FCGRT in cells led to loss of the sensitivity to Echoviruses 1, 6, 7, 11, 12, 25, 30,
openaire +1 more source