Results 191 to 200 of about 8,086 (233)

Glycoengineering of plant-produced Pembrolizumab enhances FcRn binding and extends serum half-life in mice. [PDF]

Biotechnol Rep (Amst)
Bulaon CJI, Jaratsittisin J, Rattanapisit K, Suwanchaikasem P, Guo S, Boonha K, Pitaksajjakul P, Simsom N, Limprasutr V, Phoolcharoen W.   +9 more
europepmc   +1 more source

Therapeutic Antibodies in Hematology: Advances in Malignant and Non-Malignant Disorders. [PDF]

Cells
Yasui H, Idogawa M, Ishida T, Imai K.
europepmc   +1 more source

Prediction of Monoclonal Antibodies Pharmacokinetics in Human: Identification of a Reference Neonatal Fc Receptor (FcRn) Binding Affinity Using Physiologically Based Pharmacokinetic (PBPK) Modeling

Salih Benamara, Erik Sjögren, Florence Gattacceca, Marylore Chenel, Antoine Deslandes, Laurent Nguyen, Donato Teutonico   +6 more
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FcRn: the neonatal Fc receptor comes of age

Nature Reviews Immunology, 2007
The neonatal Fc receptor for IgG (FcRn) has been well characterized in the transfer of passive humoral immunity from a mother to her fetus. In addition, throughout life, FcRn protects IgG from degradation, thereby explaining the long half-life of this class of antibody in the serum. In recent years, it has become clear that FcRn is expressed in various
Roopenian, D C, Akilesh, S
openaire   +2 more sources

Colostrogenesis: Role and Mechanism of the Bovine Fc Receptor of the Neonate (FcRn)

Journal of Mammary Gland Biology and Neoplasia, 2021
Colostrogenesis is a separate and unique phase of mammary epithelial cell activity occurring in the weeks before parturition and rather abruptly ending after birth in the bovine. It has been the focus of research to define what controls this process and how it produces high concentrations of specific biologically active components important for the ...
Craig R. Baumrucker, Ann L. Macrina, Rupert M. Bruckmaier   +2 more
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The neonatal Fc receptor (FcRn) expression in the human skin

Virchows Archiv, 2007
The neonatal Fc receptor, FcRn, has a wide expression within the human body, including adult cells; however, it is not ubiquitously expressed (reviewed in [2]). The receptor is involved both in IgG transcytosis as well as recycling, being able to bind both free and antigen complexed IgG molecules (reviewed in [4]). Cauza et al.
Petru, Cianga, Corina, Cianga, Petru, Plamadeala, Daciana, Branisteanu, Eugen, Carasevici   +4 more
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The neonatal Fc receptor (FcRn) is expressed in the bovine lung

Veterinary Immunology and Immunopathology, 2004
In neonatal calves, maternal immunoglobulin (Ig) is transferred into respiratory secretion which contributes to protection against pathogens. The early predominance of IgG1 in respiratory tract secretions is progressively reduced in favor of IgA by age but in the lower, bronchoalveolar system secreted IgG remains the dominant secreted Ig even in ...
Balázs, Mayer, Zsuzsanna, Kis, Gyozo, Kaján, László V, Frenyó, Lennart, Hammarström, Imre, Kacskovics   +5 more
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Expression of the neonatal Fc receptor (FcRn) at the blood–brain barrier

Journal of Neurochemistry, 2002
AbstractThe blood–brain barrier (BBB) restricts transport of immunoglobulin G (IgG) in the blood to brain direction. However, IgG undergoes rapid efflux in the brain to blood direction via reverse transcytosis across the BBB after direct intracerebral injection. This BBB IgG transport system has the characteristics of an Fc receptor (FcR), but there is
Felix, Schlachetzki, Chunni, Zhu, William M, Pardridge   +2 more
openaire   +2 more sources

Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland

Journal of Dairy Research, 2005
In ruminants, protective immunoglobulins are transferred to the newborn via colostrum to mediate maternal immunity. There is a high selectivity in the transport of immunoglobulins from the maternal plasma across the mammary barrier into the colostrum, and only IgG1 is transferred in large amounts.
Balázs, Mayer, Márton, Doleschall, Balázs, Bender, János, Bartyik, Zsuzsanna, Bosze, László V, Frenyó, Imre, Kacskovics   +6 more
openaire   +2 more sources