Results 201 to 210 of about 8,086 (233)
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Localization of the human neonatal Fc receptor (FcRn) in human nasal epithelium
Protoplasma, 2015The airway epithelium is a central player in the defense against pathogens including efficient mucociliary clearance and secretion of immunoglobulins, mainly polymeric IgA, but also IgG. Pulmonary administration of therapeutic antibodies on one hand, and intranasal immunization on the other, are powerful tools to treat airway infections. In either case,
Sara, Heidl +4 more
openaire +2 more sources
Neonatal Fc receptor (FcRn): a novel target for therapeutic antibodies and antibody engineering
Journal of Drug Targeting, 2014The biomedical applications of antibodies as prophylactics, therapeutics and diagnostics are developing rapidly. Neonatal Fc receptor (FcRn) is a major IgG Fc receptor capable of facilitating the translocation of IgG. FcRn can protect IgG from intracellular catabolism, thereby increasing its half-life. In recent decade, the interaction between FcRn and
Yuan, Wang +3 more
openaire +2 more sources
Human Immunology, 2011
The neonatal Fc receptor (FcRn) was demonstrated to play a role both in the recycling and thus the protection of immunoglobulin G (IgG) from catabolism and in the maternal-fetal transfer of IgG. The expression of this particular receptor was evidenced in a variety of cell types, but the endothelial cell was considered the main cell able to perform both
Corina, Cianga +3 more
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The neonatal Fc receptor (FcRn) was demonstrated to play a role both in the recycling and thus the protection of immunoglobulin G (IgG) from catabolism and in the maternal-fetal transfer of IgG. The expression of this particular receptor was evidenced in a variety of cell types, but the endothelial cell was considered the main cell able to perform both
Corina, Cianga +3 more
openaire +2 more sources
Regulation of Immunological Responses by the Neonatal Fc Receptor for IgG, FcRn
2013Immunoglobulins (Ig) are the hallmark of the humoral immune system and can be found, in varying concentrations, in all tissues of the body as well as throughout the circulatory system. Of the various isotypes, IgG is by far the most abundant in serum due to its extremely long half-life of 7–23 days.
Kristi Baker +2 more
openaire +1 more source
Protein Expression and Purification, 2016
Neonatal Fc-receptor (FcRn) with its affinity to immunoglobulin G (IgG) has been the subject of many pharmacokinetic studies in the past century. This protein is well known for its unique feature in maintaining the circulating IgG from degradation in blood plasma. FcRn is formed by non-covalent association between the α-chain with the β-2-microglobulin
Woei Kean Ng +2 more
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Neonatal Fc-receptor (FcRn) with its affinity to immunoglobulin G (IgG) has been the subject of many pharmacokinetic studies in the past century. This protein is well known for its unique feature in maintaining the circulating IgG from degradation in blood plasma. FcRn is formed by non-covalent association between the α-chain with the β-2-microglobulin
Woei Kean Ng +2 more
openaire +2 more sources
Annals of Biomedical Engineering, 2005
We constructed a novel physiologically-based pharmacokinetic (PBPK) model for predicting interactions between the neonatal Fc receptor (FcRn) and anti-carcinoembryonic antigen (CEA) monoclonal antibodies (mAbs) with varying affinity for FcRn. Our new model, an integration and extension of several previously published models, includes aspects of mAb ...
Gregory Z, Ferl +2 more
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We constructed a novel physiologically-based pharmacokinetic (PBPK) model for predicting interactions between the neonatal Fc receptor (FcRn) and anti-carcinoembryonic antigen (CEA) monoclonal antibodies (mAbs) with varying affinity for FcRn. Our new model, an integration and extension of several previously published models, includes aspects of mAb ...
Gregory Z, Ferl +2 more
openaire +2 more sources
[Neonatal Fc receptor (FcRn)-A Novel Therapeutic Approach for Autoimmune Disease].
Brain and nerve = Shinkei kenkyu no shinpoNeonatal Fc receptor (FcRn) is involved in recycling of IgG. Recycling begins with IgG-uptake into the cell through pinocytosis. Subsequently, IgG binds to FcRn in acidic vesicles, which results in the recycling of the FcRn-IgG complex to cell surface, and the release of IgG in blood with neutral pH. Whereas IgG unbound to FcRn is not recycled and thus
Hiroyuki, Murai, Daisuke, Harada
openaire +1 more source
Critical care management of chimeric antigen receptor T‐cell therapy recipients
Ca-A Cancer Journal for Clinicians, 2022Alexander Shimabukuro-Vornhagen +2 more
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