Results 21 to 30 of about 69,213 (212)

Hydroxyurea for Malignant Pertussis in Critically Ill Children

Critical Care Explorations
OBJECTIVES:. Malignant pertussis, the most severe manifestation of Bordetella pertussis infection, is characterized by multiple organ failure and a high mortality rate despite advanced intensive care measures.
Matthieu Blanc, MD, Clémence Marais, MD, MSc, Alexandre Debs, MD, Vladimir L. Cousin, MD, Pierre Tissières, MD, DSc, on behalf of the Paris Saclay Neonatal and Pediatric ICU Research Alliance (PANDORA) Study Group, Melissa Beggaz, MD, Matthieu Blanc, MD, Claire Boithias, MD, MSc, Charlotte Brognion, MD, Diane Carriere, MD, MSc, Ramy Charbel, MD, Caroline Claude, MD, MSc, Mafoudia Conde, MD, Vladimir L. Cousin, MD, Alexandre Debs, MD, Narjess Ghali, MD, Laure Jule, MD, Clémence Marais, MD, MSc, Jordi Miatello, MD, PhD, Luc Morin, MD, MSc, Francisco Oddone, MD, Arnaud Terzic, MD, Pierre Tissières, MD, DSc, Sarah Touati, MD, MSc.   +24 more
doaj   +1 more source

Precision Medicine for Neonatal Sepsis

Frontiers in Molecular Biosciences, 2018
Neonatal sepsis remains a significant cause of morbidity and mortality especially in the preterm infant population. The ability to promptly and accurately diagnose neonatal sepsis based on clinical evaluation and laboratory blood tests remains ...
Sherrianne Ng, Tobias Strunk, Pingping Jiang, Tik Muk, Per T. Sangild, Andrew Currie, Andrew Currie   +6 more
doaj   +1 more source

Nirsevimab prophylaxis on pediatric intensive care hospitalization for severe acute bronchiolitis: a clinical and economic analysis

Annals of Intensive Care
Background Severe acute viral bronchiolitis is a common cause of admissions to pediatric intensive care units (PICUs), resulting in a significant organizational burden each winter.
Sarah Touati, Alexandre Debs, Luc Morin, Laure Jule, Caroline Claude, Pierre Tissieres, the PANDORA study group   +6 more
doaj   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Soft, Multi‐Wavelength Photoplethysmography Enables Reliable Neonatal Blood Pressure Monitoring Via Error Stratification

Advanced Science, EarlyView.
A soft hybrid multi‐wavelength PPG wearable acquires neonatal signals. Synchronized PPG and invasive ABP data are segmented into fixed windows. A 1D‐EfficientNet model predicts segment‐level SBP and DBP. Model performance is examined with retrospective subgroup analysis across acquisition conditions.
Wenqi Shi, Lanlan Mi, Jiarong Chen, Biao Liu, Min Wang, Zisheng Dai, Bin Liu, Ruize Gao, Yunfeng Lin, Weiwei Guo, Guoxing Wang, Wenyi Luo, Cheng Chen   +12 more
wiley   +1 more source

The microbiology of neonatal sepsis in a rural Ecuadorian hospital

Práctica Familiar Rural
Introduction: Neonatal sepsis continues to be a public health problem in Latin America. This study aims to describe the bacterial causes of early and late onset neonatal sepsis in a neonatal ICU in a rural hospital in Ecuador.
Danny Larco, Lider Pico Menendez, David Gaus   +2 more
doaj   +1 more source

Developing Highly Effective Nanoparticle mRNA Therapeutic for Pediatric Acute Respiratory Distress Syndrome

Advanced Science, EarlyView.
Sepsis‑induced pediatric acute respiratory distress syndrome suppresses FOXF1 in lung endothelial cells which causes life‐threatening lung damage. To counter this, researchers developed nanoparticles that specifically target these cells and deliver FOXF1 mRNA.
Zicheng Deng, Wen Gao, Jonathan Do, Danli Lu, Ying‐Wei Lan, Andreas Damianos, Gautam Verma, Ali Al Siraj, Isabella Lowry, Lance Peter, Nicholas E. Banovich, Fei Sun, Hua He, Tanya V. Kalin, Vladimir V. Kalinichenko   +14 more
wiley   +1 more source

Over the edge: Empirical evidence for the cliff‐edge model of obstetric selection

The Anatomical Record, EarlyView.
Abstract The cliff‐edge model of obstetric selection maintains that larger neonates and smaller birth canals confer a positive selective advantage until labor becomes obstructed and vaginal delivery is no longer possible, eliciting an abrupt reduction in fitness.
Laura M. Watson, Pierre Frémondière, Kaspar Staub, Philipp Mitteroecker, Barbara Fischer, Martin Haeusler, Nicole M. Webb   +6 more
wiley   +1 more source

How Can the Microbiologist Help in Diagnosing Neonatal Sepsis?

International Journal of Pediatrics, 2012
Neonatal sepsis can be classified into two subtypes depending upon whether the onset of symptoms is before 72 hours of life (early-onset neonatal sepsis—EONS) or later (late-onset neonatal sepsis—LONS).
Michela Paolucci, Maria Paola Landini, Vittorio Sambri   +2 more
doaj   +1 more source

Neonatal sepsis and its association with birth weight and gestational age among admitted neonates in Ethiopia: systematic review and meta-analysis

BMC Pediatrics, 2020
Background Neonatal sepsis is an invasive infection, usually bacterial, and often occurring during the neonatal period (0–28 days). Neonatal sepsis causes a high burden of morbidity and mortality in developing countries like Ethiopia.
Amare Belachew, Tilahun Tewabe
doaj   +1 more source