Results 51 to 60 of about 141,336 (294)

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Is 24 hour observation in hospital after stopping intravenous antibiotics in neonates justified? [PDF]

, 2009
Background: Antibiotics are given empirically for suspected sepsis in up to 75% of neonates on the Neonatal and Paediatric Intensive Care Unit (NPICU), after completion of a septic screen. Treatment is discontinued on day 3 if cultures remain negative or
Andrejevic, Hermoine, Attard Montalto, Simon, Fenech, Josella, Said Conti, Valerie   +3 more
core  

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Vascular Endothelium in Neonatal Sepsis: Basic Mechanisms and Translational Opportunities

Frontiers in Pediatrics, 2019
Neonatal sepsis remains a major health issue worldwide, especially for low-birth weight and premature infants, with a high risk of death and devastating sequelae.
Carlo Pietrasanta, Carlo Pietrasanta, Carlo Pietrasanta, Lorenza Pugni, Andrea Ronchi, Ilaria Bottino, Beatrice Ghirardi, Guzman Sanchez-Schmitz, Guzman Sanchez-Schmitz, Francesco Borriello, Francesco Borriello, Francesco Borriello, Francesco Borriello, Francesco Borriello, Fabio Mosca, Fabio Mosca, Ofer Levy, Ofer Levy, Ofer Levy   +18 more
doaj   +1 more source

Aetiology of community-acquired neonatal sepsis in low and middle income countries [PDF]

, 2011
99% of the approximate 1 million annual neonatal deaths from life-threatening invasive bacterial infections occur in developing countries, at least 50% of which are from home births or community settings.
Ahmad, Aziez, Campbell, Harry, Jawad, Issrah, Lukšić, Ivana, Nair, Harish, Rudan, Igor, Theodoratou, Evropi, Waters, Donald, Zaidi, Anita K M, Zgaga, Lina   +9 more
core   +1 more source

Retrospective, Multicenter Study of Lacosamide to Treat Neonatal Seizures

Annals of the Child Neurology Society, EarlyView.
ABSTRACT Objective Most antiseizure medications (ASMs) are prescribed off label for neonates. Lacosamide's efficacy in infants and availability in intravenous formulation suggest potential utility for neonates. We evaluated the safety and efficacy of lacosamide for neonatal seizures. Methods This 10‐center, retrospective study of neonates with seizures
Alexandra Santana Almansa, Jessica R. Landers, Nicholas S. Abend, Giulia M. Benedetti, Catherine J. Chu, Andrew T. Knox, Shavonne Massey, Steffany Moen, Andrea C. Pardo, Arnold Sansevere, Renée A. Shellhaas, Cameron Thomas, Tammy Tsuchida, Sonya Wang, Bo Zhang, Janet S. Soul   +15 more
wiley   +1 more source

Clean birth kits to improve birth practices: development and testing of a country level decision support tool [PDF]

, 2012
Background: Clean birth practices can prevent sepsis, one of the leading causes of both maternal and newborn mortality. Evidence suggests that clean birth kits (CBKs), as part of package that includes education, are associated with a reduction in newborn
A Ayaz, A Cameron, A Nyamtema, AC Seale, Bilal I Avan, ER van Teijlingen, ER van Teijlingen, H Blencowe, H Hassan, Harding A (Chair) Partnerships with the Private Sector in Health, Haris Ahmed, I Holloway, I Jehan, J Bryce, J Raven, K Forrest Keenan, KS Khan, National Institute of Population Studies (NIPS) [Pakistan], and Macro International Inc, S Soofi, UN Commission on Life-Saving Commodities, USAID, V Hundley, V Hundley, V Hundley, Vanora A Hundley, W Graham, Wendy J Graham, WHO, UNICEF, UNFPA and the World Bank, World Health Organization, World Health Organization and Global Health Workforce Alliance, World Health Organization, Department of Reproductive Health and Research, World Health Organization, Division of Reproductive Health (Technical Support)   +31 more
core   +4 more sources

Machine learning applied to serum and cerebrospinal fluid metabolomes revealed altered arginine metabolism in neonatal sepsis with meningoencephalitis

Computational and Structural Biotechnology Journal, 2021
Background: Neonatal sepsis with meningoencephalitis is a common complication of sepsis, which is a leading cause of neonatal death and neurological dysfunction.
Peng Zhang, Zhangxing Wang, Huixian Qiu, Wenhao Zhou, Mingbang Wang, Guoqiang Cheng   +5 more
doaj   +1 more source

A proposed role for sepsis in the pathogenesis of myocardial calcification [PDF]

, 2017
Myocardial calcification is a rare and life-threatening condition that is a recognised complication of ischaemic heart disease, cardiac surgery, rheumatic fever and myocarditis.
AROMATARIO, MARIAROSARIA, Ashrafian, Hutan, Athanasiou, Thanos, Bower, Guy, CAPPELLETTI, SIMONE, CIALLELLA, Costantino, Harling, Leanne, Lee, Liang Mei   +7 more
core   +1 more source

Systematic review and network meta-analysis with individual participant data on cord management at preterm birth (iCOMP): study protocol [PDF]

, 2020
Introduction Timing of cord clamping and other cord management strategies may improve outcomes at preterm birth. However, it is unclear whether benefits apply to all preterm subgroups.
Andersson, Ola, Askie, Lisa, Barba, Angie, Datta, Vikram, Davis, Peter G., De Paco Matallana, Catalina, Debray, Thomas, Dempsey, Eugene, Duley, Lelia, El-Naggar, Walid, Fairchild, Karen, Hooper, Stuart B., Hosono, Shigeharu, Hunter, Kylie E., Josephsen, Justin, Katheria, Anup C., Kattwinkel, John, Kluckow, Martin, Mercer, Judith, Montgomery, Alan, Polglase, Graeme, Rabe, Heike, Seidler, Anna Lene, Simes, John, Sundaram, Venkataseshan, Tarnow-Mordi, William   +25 more
core   +3 more sources