Results 121 to 130 of about 88,069 (217)

Melatonin Mitigates Doxorubicin‐Induced Cardiotoxicity by Targeting the USP18/PKM2 Axis Without Compromising Antitumor Efficacy

Advanced Science, EarlyView.
Melatonin engages MT1/MT2 receptors to suppress STAT1‐driven USP18 upregulation, thereby redirecting PKM2 ubiquitination from K33‐linked autophagic degradation toward K27‐linked nuclear translocation. This prevents PKM2‐mediated proinflammatory gene expression in the heart, alleviating doxorubicin‐induced cardiotoxicity without compromising antitumor ...
Zhenyu Feng, Yijin Yang, Jie Bai, Pengqi Sun, Xuyang Sun, Jinshu Shang, Yang Liu, Zhen Ning, Ningning Zhang, Yun‐long Xia, Yunpeng Xie   +10 more
wiley   +1 more source

Alobar Holoprosencephaly with Severe Craniofacial Anomalies and Congenital Diaphragmatic Hernia: First Reported Case from Somalia. [PDF]

Pediatric Health Med Ther
Osman IM, Mohamed AM, Abdi KS, Mohamed NM.   +3 more
europepmc   +1 more source

A Novel Immunosuppressive Effector Functions as a Bio‐Adjuvant to Enhance the Activity of Bacillus Thuringiensis and Chemical Insecticides

Advanced Science, EarlyView.
A previously unrecognized link between quorum sensing and host immune suppression is revealed in Bacillus thuringiensis(Bt). The PlcR‐PapR system induces the novel immunosuppressive effector PisP, which inhibits DAF‐16 nuclear translocation and downstream immune defenses, thereby promoting Bt pathogenicity.
Zhiyu Liu, Feng Chen, Liting Wan, Li Chen, Bowen Zhang, Fanling Li, Haixin Luo, Lixu Li, Alejandra Bravo, Mario Soberón, Dadong Dai, Jinshui Zheng, Ming Sun, Kai Wang, Donghai Peng   +14 more
wiley   +1 more source

Case Report: Refractory life-threatening post-biopsy hemorrhage in a neonate successfully controlled with Ankaferd Blood Stopper. [PDF]

Front Pediatr
Imdadoglu T, Guzel B, Coskun S, Okbay Gunes A, Altuncu E.   +4 more
europepmc   +1 more source

Non‐Canonical Function of DDX21 in Fetal Hematopoiesis Antagonizes KDM5A‐Mediated Repression of Ribosomal and Hematopoietic Genes

Advanced Science, EarlyView.
This study demonstrates a mechanism by which RNA helicase DDX21 coordinates the transcription of hematopoietic and ribosomal genes by interacting with the H3K4me3 demethylase KDM5A. The DDX21‐KDM5A complex co‐occupies active genes in hematopoietic progenitors, thereby ensuring their rapid proliferation during fetal hematopoiesis.
Adrian On‐Wah Leung, Chang Li, Xianyin Huang, Zhuming Fan, Yuning Chen, Jiaxing Liu, Hong Man Lin, Xiaoming Cui, Fujia Zhang, Ruoxi Niu, Kam Tong Leung, Boxian Huang, Hoi‐Hung Cheung   +12 more
wiley   +1 more source

A Novel Bioactive Component, Efoba, From Aged Garlic Targets CTSC to Suppress NET‐Driven Neuroinflammation and Ameliorate Secondary Brain Injury After Intracerebral Hemorrhage

Advanced Science, EarlyView.
Efoba, a novel bioactive component derived from aged garlic, confers neuroprotection against intracerebral hemorrhage. It acts on microglia to suppress CTSC release, inhibits NET‐mediated neural injury, and blocks pathological microglia‐neutrophil crosstalk. This study provides a highly promising lead compound for hemorrhagic‐stroke therapy.
Junjun Meng, Jianhua Wang, Tao Zhang, Xiaofan Fan, Jinxiu Guo, Shiyuan Zhao, Wenxue Sun, Pei Jiang   +7 more
wiley   +1 more source

Candidemia and invasive candidiasis in children and neonates: transposing adult diagnostic recommendations may undermine end-organ screening. [PDF]

Braz J Infect Dis
Pessoa FS.
europepmc   +1 more source

A Bi‐Adjuvant Senolytic Nanovaccine Modulating Dendritic Cell Senescence Ameliorates Aging‐Related Metabolic Dysfunction

Advanced Science, EarlyView.
An active biomaterial‐based bi‐adjuvant nanovaccine restores the immunocompetence of aged dendritic cells to overcome senescent cell tolerance. Accompanied by the downregulation of mitotic kinases Aurka/b and attenuation of senescence‐associated PI3K/AKT phosphorylation, the nanovaccine enhances antigen‐presenting capacity and promotes potent cytotoxic
Qingxu Song, Xiaoxue Du, Wenbo Dong, Ying Wang, Xiaojing Wang, Qiliang Yin   +5 more
wiley   +1 more source

Necrotizing Enterocolitis Secondary to Congenital Syphilis in an 18-Day-Old Neonate: Successful Treatment With Intravenous Penicillin. [PDF]

Case Rep Infect Dis
Chap C, Bin V, Bin S.
europepmc   +1 more source

Rethinking Cochlear Implants: The Need for Precise Temporal Coding

Advanced Science, EarlyView.
Spatial hearing relies on sensitivity to interaural temporal cues, but this sensitivity is often poorly developed in patients with cochlear implants, particularly those with early‐onset hearing loss. Rats with cochlear implants, however, demonstrate excellent temporal sensitivity, suggesting that this limitation is not inevitable.
Nicole Rosskothen‐Kuhl, Jan W. H. Schnupp   +1 more
wiley   +1 more source