Results 81 to 90 of about 251,664 (236)

Chemopreventive Effect of Bitter Melon (Momordica charantia) Juice on Pancreatic Carcinogenesis in LSL‐KrasG12D/+; p48Cre/+ Mice

Molecular Carcinogenesis, EarlyView.
ABSTRACT Herein, using the LSL‐KrasG12D/+; p48Cre/+ transgenic mouse model [that recapitulates the full spectrum of human disease, progressing from early pancreatic intraepithelial neoplasia lesions to invasive pancreatic ductal adenocarcinoma (PDAC)], we determined the chemopreventive effect of long‐term (chronic) administration of Bitter Melon Juice (
Lakshmi Sai Pratyusha Bugata, Deepanshi Dhar, Rama Kant, Robin Kumar, Md. Imtiazul Kabir, Chapla Agarwal, Rajesh Agarwal, Komal Raina   +7 more
wiley   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Impact of menopausal status on human papillomavirus detection and cervical neoplasia in middle-aged Senegalese women. [PDF]

PLoS One
Spencer ER, Winer RL, Ba S, Sy MP, Lin J, Feng Q, Gottlieb GS, Sow PS, Kiviat NB, Hawes SE.   +9 more
europepmc   +1 more source

A Population of HLA-DR+ Immature Cells Accumulates in the Blood Dendritic Cell Compartment of Patients with Different Types of Cancer

, 2005
Dendritic cell (DC) defects are an important component of immunosuppression in cancer. Here, we assessed whether cancer could affect circulating DC populations and its correlation with tumor progression.
Schmidt, C, O'Connor, L, Pyke, C, Walker, D, Ho, CSK, Laherty, R, Gardiner, RA, Maxwell, T, Pinzon-Charry, A, Furnival, C, Lopez, JA   +10 more
core  

Corrigendum to "P53-independent partial restoration of the p53 pathway in tumors with mutated p53 through ATF4 transcriptional modulation by ERK1/2 and CDK9" [Neoplasia, Volume 23 (2021) 304-325]. [PDF]

Neoplasia
Tian X, Ahsan N, Lulla A, Lev A, Abbosh P, Dicker DT, Zhang S, El-Deiry WS.   +7 more
europepmc   +1 more source

Systematic Review and Meta‐Analysis: Plant‐Based Therapy for Irritable Bowel Syndrome

Phytotherapy Research, EarlyView.
ABSTRACT Irritable bowel syndrome (IBS) is a common disorder of brain‐gut interaction that presents with abdominal pain, bloating associated with variable stool consistency. Many IBS patients prefer plant‐based preparations to pharmacological therapy; however, the utility of this approach is not well established.
Anselm Meyer, Jonas Auer, Lorena Cascant‐Ortolano, Niclas Schreiber, Amy Zimmermann‐Klemd, Carsten Gründemann, Philipp Busche, Jörg Schirra, Mark R. Fox   +8 more
wiley   +1 more source

Crystal Violet Staining for Colitis-associated Neoplasia-guided Delineation of Ulcerative Colitis-associated Neoplasia for Endoscopic Submucosal Dissection: A Four-case Report. [PDF]

DEN Open
Tomioka A, Chiya N, Hokari R, Ryozawa S.
europepmc   +1 more source

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

Pink Polypoid Papulo‐Vesicles on Labia Majora

JEADV Clinical Practice, EarlyView.
Maria Chiara Mercuri, Michela Tabanelli, Silvia Zago, Diego Abbenante   +3 more
wiley   +1 more source