Results 71 to 80 of about 1,272,565 (330)

JulianA: An automatic treatment planning platform for intensity-modulated proton therapy and its application to intra- and extracerebral neoplasms [PDF]

arXiv, 2023
Creating high quality treatment plans is crucial for a successful radiotherapy treatment. However, it demands substantial effort and special training for dosimetrists. Existing automated treatment planning systems typically require either an explicit prioritization of planning objectives, human-assigned objective weights, large amounts of historic ...
arxiv  

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Clinical reasoning in canine spinal disease: what combination of clinical information is useful? [PDF]

, 2015
Spinal disease in dogs is commonly encountered in veterinary practice. Numerous diseases may cause similar clinical signs and presenting histories. The study objective was to use statistical models to identify combinations of discrete parameters from the
ABRAMSON, ARMAŞU, AWANO, BAGLEY, BESALTI, BRISSON, DA COSTA, DA COSTA, DA COSTA, DE DECKER, DE RISIO, DE RISIO, DE RISIO, DELAMAIDE GASPER, DRIVER, GANDINI, HOLDER, JEFFERY, JULL, KRANENBURG, LANE, LEVINE, LU, MAY, MCKEE, MEIJ, PALUS, PARENT, PARK, RUSBRIDGE, RUSBRIDGE, SCHMIDT, TABACHNICK, TIPOLD, TIPOLD, VAN WIE, ZENG   +36 more
core   +2 more sources

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

A Cerebellar High-Grade Neuroepithelial Tumour with BCOR Alteration in a five-year-old Child: A case report. [PDF]

, 2019
New groups of high-grade neuroepithelial tumours (HGNET) have emerged from the reclassification of central nervous system (CNS) embryonal tumours that have recognised CNS HGNET with BCOR alteration (CNS HGNET-BCOR).
Al Hajri, Zahra, Al-Battashi, Abeer, Al-Ghaithi, Ibrahim, Al-Kindi, Hunaina, Perry, Arie   +4 more
core   +1 more source

Comparative analysis of diagnostic performance, feasibility and cost of different test-methods for thyroid nodules with indeterminate cytology [PDF]

, 2017
Since it is impossible to recognize malignancy at fine needle aspiration (FNA) cytology in indeterminate thyroid nodules, surgery is recommended for all of them. However, cancer rate at final histology is < 30%.
AIOM-AIRTUM Working Group, AIRTUM Working Group, Alexander, Alexander, Ali, Altman, Attia, Baldari, Baloch, Bartolazzi, Bartolazzi, Bartolazzi, Beaudenon-Huibregtse, Bevilacqua, Beyer, Biggerstaff, Birkeland, Bongiovanni, Burch, Cabatu, Carpi, Carty, Chhieng, Choi, Chung, Chung, Corsello, Cvejić, D'Armiento, da Silva Pinhal, de Geus-Oei, de Geus-Oei, degli Uberti, Eszlinger, Evans, Evans, Fadda, Fadda, Fox, Gharib, Girelli, Gupta, Gupta, Gupta, Heffron, Jo, Kebebew, Kennedy, Kennedy, Khanafshar, Kwak, Labourier, Ladenson, Larsson, Lotan, Mazzaferri, McGee, McGregor, Michael, Moher, Moley, Montori, Newbold, Niederle, Nikiforova, Nikiforova, Nikiforova, Nishino, Oh, Orlandi, Osman, Paik, Papotti, Paschke, Paschke, Paschke, Pastorino, Payne, Perros, Plotly Technologies Inc., Puxeddu, R Core Team, Rabinovich, Rindi, Rosenthal, Rosenthal, Rugge, Sadler, Saxe, Schachter, Schlumberger, Schmid, Schreyögg, Sciacchitano, Sciacchitano, Shah, Shi, Shong, Siperstein, Sosa, Stephen, Steward, Teng, Tonacchera, van de Velde, Verburg, Veselic, Vierhapper, Vitti, Vitti, Vitti, Wasserman, Westra, Wiseman, Woeber, Xing, Yu, Zantut-Wittmann, Zatelli, Zeiger   +119 more
core   +2 more sources

Marked Variability in Reported Minimal Residual Disease Lower Level of Detection of 4 Hematolymphoid Neoplasms: A Survey of Participants in the College of American Pathologists Flow Cytometry Proficiency Testing Program [PDF]

Archives of Pathology & Laboratory Medicine, 2015
Context Flow cytometry is often applied to minimal residual disease (MRD) testing in hematolymphoid neoplasia. Because flow-based MRD tests are developed in the laboratory, testing methodologies and lower levels of detection (LODs) are laboratory dependent ...
David M. Dorfman, William J. Karlon, Michael A. Linden, Steven J. Kussick, Michael Keeney, Kumudini U. Mehta, Daniel D. Rhoads, Jaimie G. Halley, M. Qasim Ansari   +8 more
openaire   +2 more sources

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source