Results 41 to 50 of about 95,062 (267)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Specific features of proliferation and apoptosis in non-invasive adenocarcinoma of endometrium and adenocarcinoma with invasion into myometrium

Patologìâ, 2014
Introduction. The development of tumors occurs as a multistage process, where each step corresponds to certain genetic changes of cells and it is a reflection characteristic of different histological forms of cancer. This usually multiple changes include
V. O. Tumanskiy, M. M. Baudarbekova, O. V. Chepets   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Pathological and Clinical Significance of Tumor Budding and Its Association with Epithelial-Mesenchymal Transition in Colorectal Carcinoma: A Retrospective Observational Study [PDF]

Iranian Journal of Medical Sciences
Background: Metastases, not the primary tumor, account for most cancer-related deaths. Tumor budding, thought to represent epithelial-mesenchymal transition (EMT), has garnered attention due to its association with invasion and migration. This study aims
Bashar Al Hassawi
doaj   +1 more source

Research Progress of Long Non-Coding RNA GAS5 in Malignant Tumors

Frontiers in Oncology, 2022
With completing the whole genome sequencing project, awareness of lncRNA further deepened. The growth arrest-specific transcript 5 (GAS5) was initially identified in growth-inhibiting cells.
Guohong Lin, Tianzhun Wu, Xing Gao, Ziqin He, Wenwei Nong   +4 more
doaj   +1 more source

Ovarian neoplasms — the role of minimally invasive surgery

ecancermedicalscience
The role of minimally invasive surgery (MIS) for ovarian neoplasms in paediatric patients depends on multiple factors. First, it is important to consider the risk of malignancy, which can be difficult to assess, especially in the setting of torsion. Second, when possible ovarian sparing surgery (OSS) should be performed.
Stetson, Alyssa, Dasgupta, Roshni
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Significance of color doppler ultrasonography in the assessment of pancreatic carcinoma vascular invasion [PDF]

Vojnosanitetski Pregled, 2006
Background/Aim. It is highly appreciated to provide exact data on vascular invasion of pancreatic carcinoma relying as much as possible on non-invasive diagnostic procedures.
Alempijević Tamara, Kovačević Nada, Tomić Dragan, Đuranović Srđan, Krstić Miodrag   +4 more
doaj   +1 more source

Ginseng-based carbon dots inhibit the growth of squamous cancer cells by increasing ferroptosis

Frontiers in Oncology, 2023
BackgroundRecent studies indicated that Ginseng potentiate cancer treatments. Ginseng-based carbon dots (GCDs) might possess properties to kill cancer cells and inhibit malignant tumor development and invasion.
Zilin Wang, Zilin Wang, Jing Han, Jing Han, Zhiyong Guo, Zhiyong Guo, Zhiyong Guo, Hao Wu, Hao Wu, Hao Wu, Yige Liu, Yige Liu, Yige Liu, Wenying Wang, Chenping Zhang, Chenping Zhang, Jiannan Liu, Jiannan Liu   +17 more
doaj   +1 more source