Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Patterns of recurrence and long-term outcomes in patients who underwent pancreatectomy for intraductal papillary mucinous neoplasms with high grade dysplasia: implications for surveillance and future management guidelines [PDF]
, 2017 Aaron U. Blackham +6 more
openalex +1 more source
Recurrent cyclin D2 mutations in myeloid neoplasms [PDF]
Leukemia, 2017 Julia E. Maxson +14 more
openaire +3 more sources
Aggressive recurrence after radiofrequency ablation of liver neoplasms.
Hepato-gastroenterology, 2003 Radiofrequency ablation is considered safe for inoperable liver neoplasms; with small lesions the rate of success is very high, the local recurrence is marginal and generally suitable for a retreatment. We have little information about the possibility of rapid regrowth of the tumor after a response judged as complete. We present four patients, affected
PORTOLANI, Nazario +6 more
openaire +2 more sources
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
Outcomes of pulmonary endarterectomy for patients with pulmonary artery sarcoma
Frontiers in Cardiovascular MedicineObjectivePulmonary artery sarcoma (PAS) is an exceedingly rare and insufficiently investigated disease, leading to uncertain in its optimal management. This study aims to present our institutional experience and the outcomes of pulmonary endarterectomy ...
Zhaohua Zhang +11 more
doaj +1 more source
Resection of a Recurrent Metastatic Leptomeningeal Melanoma: Case Report and Literature Review
Interdisciplinary Neurosurgery, 2023 Malignant melanoma is considered the most aggressive among all cutaneous cancer. Malignant melanoma commonly causes cerebral metastasis. The survival rate of melanoma with cerebral metastases is considerably poor.
Nyoman Golden +8 more
doaj
Understanding and measuring mechanical signals in the tumor stroma
FEBS Open Bio, EarlyView.This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz +3 more
wiley +1 more source
Philippine Journal of OrthopaedicsObjectives. A fungating soft tissue sarcoma of the extremities (F-ESTS) is a rare clinical presentation with limited literature. This study aims to describe the important clinical characteristics, treatment patterns, and outcomes of twenty patients ...
Karla Teresa Araneta +2 more
doaj +1 more source