Results 51 to 60 of about 7,162,308 (203)

Targeted transgenic RNAi knockdown of cell fate determinants induces neoplastic tumor growth and metastasis in a Drosophila transplantation model of neural stem cell derived cancer [PDF]

, 2012
Genetic models such as Drosophila have sophisticated transgenic and molecular genetic tools available to investigate proliferation control in normal and tumorigenic neural stem cells.
Reichert, Heinrich, Laurenson, Anne-Sophie, Saini, Nidhi, Jiang, Yanrui   +3 more
core   +1 more source

Methylation patterns at the adjacent CpG sites within enhancers are a part of cell identity

Epigenetics & Chromatin
Background It is generally accepted that methylation status of CpG sites spaced up to 50 bp apart is correlated, and accumulation of locally disordered methylation at adjacent CpG sites is involved in neoplastic transformation, acting in similar way as ...
Olga Taryma-Leśniak, Jan Bińkowski, Patrycja Kamila Przybylowicz, Katarzyna Ewa Sokolowska, Konrad Borowski, Tomasz Kazimierz Wojdacz   +5 more
doaj   +1 more source

Transformation of benign phyllodes to malignant phyllodes tumor

Medicina, 2015
Importance of the problem: Malignant phyllodes tumors are rare fibroepithelial neoplasm in which clinical findings remain insufficient to determine a proper preoperative diagnoses and therefore has an unpredictable clinical outcome for optimal treatment.
Adrienne Pratti Lucarelli, Maria Marta Martins, Maria Antonieta Longo Galvão, José Mendes Aldrighi   +3 more
doaj   +1 more source

Identification of genes differentially expressed as result of adenovirus type 5- and adenovirus type 12-transformation [PDF]

, 2009
Background: Cells transformed by human adenoviruses (Ad) exhibit differential capacities to induce tumours in immunocompetent rodents; for example, Ad12-transformed rodent cells are oncogenic whereas Ad5-transformed cells are not. The E1A gene determines
Strath, Janet, Strath Janet, Kellam, P., Blair G Eric, Janet Strath, Strath, J., Paul Kellam, Georgopoulos, L.J., Georgopoulos, Lindsay J, G Eric Blair, Kellam, Paul, Blair, G Eric, Lindsay J Georgopoulos, Georgopoulos Lindsay J, Blair, G.E., Kellam Paul   +15 more
core   +1 more source

FRA1 (FOSL1) suppresses neoplastic transformation and modulates radiation responses via transcriptional control of mitogenic and stress-responsive networks

Frontiers in Cell and Developmental Biology
PurposeFOS-like antigen 1 (FRA1), encoded by FOSL1, is an inducible subunit of the AP-1 transcription factor complex and regulates gene expression in response to proliferative and environmental cues.
Wuroud Al-Khayyat, Taylor Laframboise, Jessica Dougherty, Marc S. Mendonca, Douglas R. Boreham, Douglas R. Boreham, T. C. Tai, T. C. Tai, T. C. Tai, Christopher Thome, Christopher Thome, Christopher Thome, Sujeenthar Tharmalingam, Sujeenthar Tharmalingam, Sujeenthar Tharmalingam   +14 more
doaj   +1 more source

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) arising in the setting of polycythemia vera (PV): An illustration of the emerging role of flow cytometry analysis in monitoring progression of myeloproliferative neoplasms

eJHaem, 2022
This report highlights the value of flow cytometry analysis, particularly in the setting of myeloproliferative neoplasms showing features of progression, as neoplastic plasmacytoid dendritic cell (PDC) proliferations may be present, representing either a
Siba El Hussein, Mariko Yabe, Wei Wang, Naveen Pemmaraju, Sanam Loghavi, Fatima Zahra Jelloul, Hong Fang, L. Jeffrey Medeiros, W. Richard Burack, Andrew G. Evans, Jane L. Liesveld, John M. Bennett   +11 more
doaj   +1 more source

Radiosensitivity Parameters for Neoplastic Transformations in C3H10T1/2 Cells

Radiation Research, 1987
We have evaluated radiosensitivity parameters for cellular transformation from published experimental data on neoplastic transformations induced in C3H10T1/2 cells by BEVALAC ions. The measured RBE values are well reproduced by a track theory calculation using sets of m-target parameters with either m = 2 or m = 3, suggesting a quadratic or cubic ...
Waligorski, M. P. R., Sinclair, G. L., Katz, Robert   +2 more
openaire   +3 more sources

. Modern concepts on carcinogenesis: the value of insufficiency of malignant cell elimination mechanisms in the tumor progression in case of neoplasia at different localizations [PDF]

Саратовский научно-медицинский журнал, 2016
The article presents the review of contemporary concepts of tumor induction mechanisms applicable for neoplastic transformation, promotion and proliferation.
Chesnokova N.P., Morrison V.V., Barsukov V.Yu., Ponukalina E.M., Agabekov A.l.   +4 more
doaj  

KRT14 marks a subpopulation of bladder basal cells with pivotal role in regeneration and tumorigenesis

Nature Communications, 2016
It is unclear whether there is a progenitor/stem cell in the basal layer of the urothelium in the bladder. Here, the authors identify Keratin14 positive cells that can regenerate the bladder in both a natural and injury-induced manner, and following ...
George Papafotiou, Varvara Paraskevopoulou, Eleni Vasilaki, Zoi Kanaki, Nikolaos Paschalidis, Apostolos Klinakis   +5 more
doaj   +1 more source

Prevalence and association of human papillomavirus, Epstein-Barr virus and Merkel Cell polyomavirus with neoplastic esophageal lesions in northern Iran

Caspian Journal of Internal Medicine, 2018
Background: Studies concerning on esophageal squamous cell carcinoma (ESCC) etiological factors have been done for several decades, however, results reported from various investigations were not consistent.
Yousef Yahyapour, Rabeae Rahmani, Majid Alipour, Ahad Alizadeh, Aynaz Khademian, Farzin Sadeghi   +5 more
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