Results 31 to 40 of about 206,954 (242)

Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers

Cells, 2019
As the majority of cancers and gestational diseases are prognostically stage- and grade-dependent, the ultimate goal of ongoing studies in precision medicine is to provide early and timely diagnosis of such disorders.
Valentina Karin-Kujundzic, Ida Marija Sola, Nina Predavec, Anamarija Potkonjak, Ema Somen, Pavao Mioc, Alan Serman, Semir Vranic, Ljiljana Serman   +8 more
doaj   +1 more source

The Overview of Perspectives of Clinical Application of Liquid Biopsy in Non-Small-Cell Lung Cancer

Life, 2022
The standard diagnostics procedure for non-small-cell lung cancer (NSCLC) requires a pathological evaluation of tissue samples obtained by surgery or biopsy, which are considered invasive sampling procedures.
Aleksandra Bożyk, Marcin Nicoś
doaj   +1 more source

Circulating cell-free DNA as a biomarker in the diagnosis and prognosis of colorectal cancer

Brazilian Journal of Pharmaceutical Sciences, 2018
Colorectal cancer (CRC) is a disease without evident clinical symptoms in early stages, leading to late diagnosis and disease management. Current diagnostic and prognostic tools require invasive procedures and circulating molecular biomarkers fail to ...
Isadora Bernardo David de Oliveira, Rosario Dominguez Crespo Hirata   +1 more
doaj   +1 more source

Circulating Tumor DNA as a Tool of Surveillance and Early Indicator of Relapse in Sarcoma Patients

International Journal of Medical Students
Background: The use of circulating tumor DNA (ctDNA) has been increasingly explored to monitor treatment response and recurrence surveillance in sarcoma patients. Given the minimally invasive method of measurement via blood samples, and its accuracy and
Esha Sankhala, Earl Brien, Jaya Gill, Leo Mascarenhas   +3 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Cell-Free DNA as a Diagnostic and Prognostic Biomarker in Dogs With Tumors

Frontiers in Veterinary Science, 2021
Cell-free DNA (cfDNA) is derived from apoptosis/necrosis, active cellular secretion, and lysis of circulating cancer cells or micrometastases. In humans, cfDNA is widely used in cancer diagnosis, but veterinary research has yet to be actively conducted ...
Jihu Kim, Hyeona Bae, Soomin Ahn, Sunwoo Shin, ARom Cho, Kyu-Woan Cho, Dong-In Jung, DoHyeon Yu   +7 more
doaj   +1 more source

Persistent Leukoencephalopathy Following H1N1 Infection Associated With a Novel MYRF Variant (p.Gly735Asp)

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Mutations in myelin regulatory factor (MYRF) are linked to demyelinating disorders. We report a 38‐year‐old male who developed acute symmetric leukoencephalopathy mimicking a stroke following an influenza A virus infection. While clinical symptoms markedly improved with corticosteroids, MRI revealed persistent white matter lesions, contrasting
Jinghan Hu, Leiyun Huang, Wan Zhu, Min Peng, Qiang Gong, Jing Qian   +5 more
wiley   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

CD47 expression is decreased in hematopoietic progenitor cells in patients with myelofibrosis

Brazilian Journal of Medical and Biological Research, 2018
Myelofibrosis (MF) is characterized by increased circulating hematopoietic progenitor cells (HPCs), abnormal cytokine levels, and the survival advantage of neoplastic progenitors over their normal counterparts, which leads to progressive disappearance of
A. Nonino, J.M. Nascimento, C.C. Mascarenhas, J.F. Mazzeu, R.W. Pereira, R.H. Jacomo   +5 more
doaj   +1 more source