Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma [PDF]
, 2019 Almost all multiple myeloma (MM) cases have been demonstrated to be linked to earlier monoclonal gammopathy of undetermined significance (MGUS). Nevertheless, there are no identified characteristics in the diagnosis of MGUS that have been helpful in ...
Allegra A. +7 more
core +1 more source
Mathematical modelling of cancer invasion: Phenotypic transitioning provides insight into multifocal foci formation [PDF]
arXiv, 2023 The transition from the epithelial to mesenchymal phenotype and its reverse (from mesenchymal to epithelial) are crucial processes necessary for the progression and spread of cancer. In this paper, we investigate how phenotypic switching at the cancer cell level impacts on behaviour at the tissue level, specifically on the emergence of isolated foci of
arxiv
KITD816V+ systemic mastocytosis associated with KITD816V+ acute erythroid leukaemia: first case report with molecular evidence for same progenitor cell derivation [PDF]
, 2009 Toll-like receptor (TLR)-9 recognizes CpG motifs in microbial DNA. TLR9 signalling stimulates innate antimicrobial immunity and modulates adaptive immune responses including autoimmunity against chromatin, e.g., in systemic lupus erythematosus (SLE ...
H-P Horny +4 more
core +1 more source
Neuro-Oncology Advances, 2020 AbstractBackgroundIn order to identify suitable therapeutic targets for glioma anti-angiogenic therapy, the process of neovascularization mediated by circulating angiogenic cells (CACs) needs to be scrutinized.MethodsIn the present study, we compared the expression of neovascularization-related genes by 3 circulating CAC subsets (hematopoietic ...
Peter J. van der Spek +6 more
openaire +4 more sources
Transformed epithelia trigger non-tissue-autonomous tumor suppressor response by adipocytes via activation of toll and Eiger/TNF signaling [PDF]
, 2014 High tumor burden is associated with increased levels of circulating inflammatory cytokines that influence the pathophysiology of the tumor and its environment.
Parisi, Federica +4 more
core +2 more sources
Spatial model predicts dispersal and cell turnover cause reduced intra-tumor heterogeneity [PDF]
, 2015 Most cancers in humans are large, measuring centimeters in diameter, composed of many billions of cells. An equivalent mass of normal cells would be highly heterogeneous as a result of the mutations that occur during each cell division. What is remarkable about cancers is their homogeneity - virtually every neoplastic cell within a large cancer ...
arxiv +1 more source
A deep learning model for gastric diffuse-type adenocarcinoma classification in whole slide images [PDF]
arXiv, 2021 Gastric diffuse-type adenocarcinoma represents a disproportionately high percentage of cases of gastric cancers occurring in the young, and its relative incidence seems to be on the rise. Usually it affects the body of the stomach, and presents shorter duration and worse prognosis compared with the differentiated (intestinal) type adenocarcinoma.
arxiv
TAMI-10. CIRCULATING ANGIOGENIC CELLS (CACS) IN GLIOBLASTOMA: TOWARDS DEFINING CRUCIAL FUNCTIONAL DIFFERENCES IN CAC-INDUCED NEOPLASTIC VERSUS REACTIVE NEOVASCULARIZATION [PDF]
Neuro-Oncology, 2020 Abstract In order to identify suitable therapeutic targets for glioma anti-angiogenic therapy, the process of neovascularization mediated by circulating angiogenic cells (CACs) needs to be scrutinized. In the present study we compared the expression of neovascularization-related genes by three circulating CAC subsets (HPCs, CD34+ and KDR+
Andrea Sacchetti +5 more
openaire +1 more source
Angular momentum fluxes caused by Lambda-effect and meridional circulation structure of the Sun [PDF]
, 2016 Using mean-field hydrodynamic models of the solar angular momentum balance we show that the non-monotonic latitudinal dependence of the radial angular momentum fluxes caused by Lambda-effect can affect the number of the meridional circulation cells stacking in radial direction in the solar convection zone.
arxiv +1 more source
A Multi-Scale Conditional Deep Model for Tumor Cell Ratio Counting [PDF]
arXiv, 2021 We propose a method to accurately obtain the ratio of tumor cells over an entire histological slide. We use deep fully convolutional neural network models trained to detect and classify cells on images of H&E-stained tissue sections. Pathologists' labels consisting of exhaustive nuclei locations and tumor regions were used to trained the model in a ...
arxiv