The impact of deleterious passenger mutations on cancer progression [PDF]
, 2012 Cancer progression is driven by a small number of genetic alterations accumulating in a neoplasm. These few driver alterations reside in a cancer genome alongside tens of thousands of other mutations that are widely believed to have no role in cancer and termed passengers.
arxiv +1 more source
Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]
, 2018 The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B. +2 more
core +3 more sources
PARP-1 regulates DNA repair factor availability. [PDF]
, 2018 PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth +31 more
core +2 more sources
Benign TdT-positive cells in pediatric and adult lymph nodes: a potential diagnostic pitfall [PDF]
, 2018 Benign TdT-positive cells have been documented in a variety of non-hematopoietic tissues. Scant data are however available on their presence in non-neoplastic lymph nodes.
AGOSTINELLI, CLAUDIO +8 more
core +1 more source
International Journal of Molecular SciencesExisting clinical biomarkers do not reliably predict treatment response or disease progression in patients with advanced intrahepatic cholangiocarcinoma (ICC). Circulating neoplastic-immune hybrid cells (CHCs) have great promise as a blood-based biomarker for patients with advanced ICC.
Ranish K. Patel +9 more
openaire +2 more sources
Chemotherapy treatment of multiple myeloma patients increases circulating levels of endothelial microvesicles [PDF]
, 2016 Correspondenc
Adesanya, M. Adeola +5 more
core +1 more source
Cell-permeable tumor suppressor peptides for cancer therapy: back to the future [PDF]
arXiv, 2007 Miniaturization is a hallmark of modern technologies. Notably, this feature has not spared molecular biology and its potential applications. Towards developing more effective therapeutics against cancer, studies began to explore more than a decade ago how natural tumor suppression could be translated into antineoplastic drugs.
arxiv
Towards a Computed Collateral Circulation Score in Ischemic Stroke [PDF]
arXiv, 2020 Stroke is the second leading cause of disability worldwide. In order to minimize disability, the goal of stroke treatment is to preserve tissue in the area where blood supply is decreased but sufficient to stave off cell death. Thrombectomy has been shown to offer fast and efficient reperfusion with high recanalization rates.
arxiv
Features and prognostic impact of distant metastases in 45 dogs with de novo stage IV cutaneous mast cell tumours: A prospective study [PDF]
, 2017 BACKGROUND: Distant metastases in dogs with cutaneous mast cell tumors (cMCT) are rare and incurable. The aims of this prospective study were to clarify the clinico-pathological features of stage IV cMCTs and to identify possible prognostic factors for ...
Amati, M. +10 more
core +1 more source
Single Cancer Cell Detection by Near Infrared Microspectroscopy, Infrared Chemical Imaging and Fluorescence Microspectroscopy [PDF]
AOCS Publs: Champaign (2004), pp. 241-282, Ch.12 in "Oil Seed
Analysis", 2004 Novel techniques are currently being developed and established for the accurate chemical analysis and detection of single cancer cells, single embryos and single seeds by Fourier Transform Near Infrared (FT-NIR) Microspectroscopy, Fourier Transform Infrared (FT-IR), Fluorescence and High-Resolution NMR (HR-NMR).
arxiv