Results 161 to 170 of about 152,046 (196)
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Diagnosis and individualized therapy of neoplastic meningitis
Expert Review of Anticancer Therapy, 2010Neoplastic meningitis is a diffuse dissemination of tumor cells into the cerebrospinal fluid (CSF) and/or leptomeninges. It occurs in approximately 5-10% of malignant diseases, most often in breast cancer, lung cancer, melanoma or B-cell lymphoma. Symptoms of neoplastic meningitis are head or back pain, cranial nerve palsies, diffuse radicular symptoms
Herwig, Strik, Peter, Prömmel
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Treatment of Neoplastic Meningitis with Intrathecal Temozolomide
Neurosurgery, 1999Neoplastic meningitis (NM) results from leptomeningeal dissemination of cancers arising within the central nervous system or metastasizing to the leptomeninges from systemic neoplasms. The inability to produce therapeutic drug levels intrathecally (i.t.) with systemic administration and the minimal efficacy of chemotherapeutic agents currently ...
J H, Sampson +7 more
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Neoplastic meningitis-related encephalopathy
Neurology, 2004Two cohorts of 20 patients diagnosed with neoplastic meningitis (NM) with or without encephalopathy were matched with respect to age, sex, primary tumor, and performance status. Median survival was 10 weeks (range 6 to 20 weeks) in the cohort with NM-related encephalopathy compared to 24 weeks (range 8 to 40 weeks) in the cohort without NM-related ...
Marc C, Chamberlain +2 more
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Neoplastic meningitis: diagnosis and treatment considerations
Medical Oncology, 2000Neoplastic meningitis is an increasingly recognized complication of advanced metastatic cancer and, if left undiagnosed or untreated, is characterized by rapid neurologic deterioration and death. Thus, the diagnosis and treatment of neoplastic meningitis present challenges for the clinical oncologist.
S M, Blaney, D G, Poplack
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2019
Abstract Neoplastic meningitis (NM), also known as carcinomatous meningitis or leptomeningeal metastases, is usually a late-stage complication of cancer. This complication occurs in approximately 5% of patients with cancer, but the incidence in autopsy studies is 3 times higher.
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Abstract Neoplastic meningitis (NM), also known as carcinomatous meningitis or leptomeningeal metastases, is usually a late-stage complication of cancer. This complication occurs in approximately 5% of patients with cancer, but the incidence in autopsy studies is 3 times higher.
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Toxicity of treatment for neoplastic meningitis
Current Oncology Reports, 2003Neoplastic seeding of the leptomeninges often signifies limited life expectancy. Still, patients are frequently offered aggressive multimodality therapies to palliate symptoms, and, one hopes, to prolong survival. Treatment modalities directed at the central nervous system (CNS) include radiotherapy, intra-cerebrospinal fluid (CSF) chemotherapy ...
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Neoplastic meningitis: a guide to diagnosis and treatment
Current Opinion in Neurology, 2000Neoplastic meningitis is a disease of the entire neuraxis and is pleomorphic in its clinical presentation. Diagnosis is achieved by recognition of the clinical manifestations of neoplastic meningitis followed by neuroradiography of the brain and spinal cord and examination of the cerebrospinal fluid.
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