Results 1 to 10 of about 28,793 (116)
BRCA1-Mutant Ovarian Cancer with an Unusual Presentation of Leptomeningeal Disease Early in the Course of Treatment: A Case Report [PDF]
Case Reports in OncologyIntroduction: Leptomeningeal disease is a rare and devastating complication of ovarian cancer which typically occurs in patients with advanced relapsed disease. It is challenging to treat and associated with a very poor prognosis.
Jodie Pollard +4 more
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Spinal leptomeningeal disease in patients with solid tumors: A single-center study on clinical presentation, diagnosis, treatment, and outcomes [PDF]
Brain and SpineIntroduction: Despite affecting 5-15% of metastatic cancer patients, leptomeningeal disease (LMD), and spinal LMD (sLMD) in particular, remain largely understudied.
Zoe Shaked +15 more
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Drug delivery in leptomeningeal disease: Navigating barriers and beyond
Drug DeliveryLeptomeningeal disease (LMD) refers to the infiltration of cancer cells into the leptomeningeal compartment. Leptomeninges are the two membranous layers, called the arachnoid membrane and pia mater.
Numair Arshad +4 more
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Successful response in advanced leptomeningeal disease from pleomorphic xanthoastrocytoma with BRAF/MEK inhibitors: a case report [PDF]
Frontiers in OncologyLeptomeningeal disease (LMD) is a rare metastatic complication with a grim prognosis for most patients and limited treatment strategies. Therapy is adjusted to the primary tumor from which it arises.
Maria A. Jacome +8 more
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Current Oncology, 2023 The present review aimed to establish an understanding of the pathophysiology of leptomeningeal disease as it relates to late-stage development among different cancer types.
Andrew Nguyen +7 more
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Current Problems in Cancer: Case Reports, 2021 Leptomeningeal disease remains a marker of poor prognosis for patients with metastatic spread of solid tumors. Treatment options are limited and often poorly tolerated.
Shannon P. Fortin Ensign +3 more
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Current Problems in Cancer: Case Reports, 2023 Pancreatic cancer remains an inauspicious malignancy with poor long-term outcomes. The majority of patients present with advanced disease; many suffer from consequences of local progression of disease, and survival rates remain unacceptably poor. Central
Dylan D. Walker +4 more
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Development of a Triple-Negative Breast Cancer Leptomeningeal Disease Model in Zebrafish
Cells, 2023 Leptomeningeal disease occurs when cancer cells migrate into the ventricles of the brain and spinal cord and then colonize the meninges of the central nervous system.
Udhayakumar Gopal +8 more
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Primary Glioblastoma Multiforme with Concurrent Leptomeningeal Metastasis: A Case Report [PDF]
Middle East Journal of Cancer, 2023 Brain glioblastoma multiforme with leptomeningeal metastasis is a rare medical condition. Although autopsy series have demonstrated a higher incidence of leptomeningeal metastasis, it is usually a late complication in the course of the disease.
Kazem Anvari +2 more
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Frontiers in Pediatrics, 2022 Medulloblastoma is one of the most common pediatric central nervous system malignancies worldwide, and it is characterized by frequent leptomeningeal metastasizing.
Daria Morgacheva +16 more
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