Results 1 to 10 of about 34,523 (140)
PLoS ONE, 2022 BackgroundAlthough most neoplasms result from complex interactions between the individual's genome and the environment, a percentage of cases is particularly due to inherited alterations that confer a greater predisposition to the development of tumors ...
Raphael Manhães Pessanha +3 more
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Diagnostics of hereditary cancer syndromes by ngs. A database creation experience [PDF]
Клиническая практика, 2021 Background: More than 500 thousand new cases of malignant neoplasms are registered annually in the Russian Federation, of which more than 50 thousand new cases are due to hereditary forms.
Ivan S. Abramov +8 more
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Lynch-like Syndrome and its Molecular Approaches: A Brief Report and Literature Review [PDF]
Middle East Journal of Cancer, 2023 Lynch syndrome (LS) predisposes individuals to early-onset colorectal and other Lynch-associated cancer. This disorder is an autosomal dominant genetic disturbance caused by germline mutations in one of the mismatch repair genes.
Zeinab Abdollahi +3 more
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Hereditary melanoma: a five-year study of Brazilian patients in a cancer referral center - phenotypic characteristics of probands and pathological features of primary tumors [PDF]
Anais Brasileiros de Dermatologia, 2018 : BACKGROUND: Approximately five to 10% of all melanomas occur in families with hereditary predisposition and the main high-risk melanoma susceptibility gene is the CDKN2A.
Bianca Costa Soares de Sá +4 more
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Management of Patients with Hereditary Colorectal Cancer Syndromes
GE: Portuguese Journal of Gastroenterology, 2015 Colorectal cancer (CRC) is one of the most important causes of death in the world. Hereditary CRC is found in 5–10% of CRC patients. In this review, we will focus on the major forms of hereditary CRC and their management according to the most recent ...
Catarina Brandão, Jorge Lage
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Fibroblast growth factor receptor signaling in hereditary and neoplastic disease: biologic and clinical implications. [PDF]
, 2015 Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic behavior and also development, differentiation, growth, and survival.
Helsten, Teresa +2 more
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Alʹmanah Kliničeskoj Mediciny, 2018 Up to 10% of cases of sporadic colorectal cancer are considered to be related to hereditary genetic factors. The rates of colorectal cancer related to already identified genetic factors is about 5%.
D. Yu. Pikunov +2 more
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Cancer Predisposition Syndromes and Medulloblastoma in the Molecular Era
Frontiers in Oncology, 2020 Medulloblastoma is the most common malignant brain tumor in children. In addition to sporadic cases, medulloblastoma may occur in association with cancer predisposition syndromes.
Roberto Carta +18 more
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Cutaneous Expression of Familial Cancer Syndromes
Acta Dermato-Venereologica, 2021 Genodermatoses are inherited syndromes with cutaneous manifestations. Some genodermatoses are associated with malignancy of internal organs and tissues.
Anne-Johanne Andersen +3 more
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Hereditary colorectal cancer: genetics and screening diagnostics
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2018 Aim of review. To present the data on main forms of hereditary colorectal cancer (CRC) and to discuss issues of its diagnostics, genetic testing and patient management. Summary.
O. I. Kit +6 more
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