Distinguishing wet from dry age-related macular degeneration using three-dimensional computer-automated threshold Amsler grid testing [PDF]
, 2011 Background/aims: With the increased efficacy of current therapy for wet age-related macular degeneration (AMD), better ways to detect wet AMD are needed.
Bababeygy, Simon R. +5 more
core +1 more source
Sorafenib prevents human retinal pigment epithelium cells from light-induced overexpression of VEGF, PDGF and PlGF [PDF]
, 2010 Background Cumulative light exposure is significantly associated with progression of age-related macular degeneration (AMD). Inhibition of vascular endothelial growth factor is the main target of current antiangiogenic treatment strategies in AMD ...
Alge, C. S. +7 more
core +3 more sources
Gene Transfer for Neovascular Age-Related Macular Degeneration [PDF]
Human Gene Therapy, 2011 Age-related macular degeneration (AMD) is a complex disease that has two phases: a degenerative phase often referred to as nonneovascular AMD (non-NVAMD) or dry AMD and a phase dominated by growth of new blood vessels in the subretinal space, referred to as NVAMD or wet AMD.
Peter A. Campochiaro
openalex +4 more sources
Aflibercept for neovascular age-related macular degeneration
Cochrane Database of Systematic Reviews, 2016 Central vision loss caused by age-related macular degeneration (AMD) is the leading cause of blindness among the elderly in developed countries. Neovascular AMD is characterized by choroidal neovascularization (CNV). Growth of new blood vessels in patients with neovascular AMD is driven by a complex process that involves a signal protein called ...
Mohammad Ali Sadiq +9 more
openaire +4 more sources
New Therapies of Neovascular AMD beyond Anti-VEGF Injections
Vision, 2018 Neovascular age-related macular degeneration is a leading cause of vision loss among the aging population. The current standard of care to treat neovascular age-related macular degeneration is inhibiting vascular endothelial growth factor (VEGF) through ...
Greggory M. Gahn, Arshad M. Khanani
doaj +1 more source
Case Reports in Ophthalmology, 2022 We describe the results of very early pars plana vitrectomy, subretinal r-tPA, and gas tamponade in patients with subretinal macular hemorrhage secondary to neovascular age-related macular degeneration.
Filippo Confalonieri +3 more
doaj +1 more source
Plasma lipoprotein subfraction concentrations are associated with lipid metabolism and age-related macular degeneration [PDF]
, 2017 10.1194/jlr.M073684Journal of Lipid Research5891785 ...
Apte, Rajendra S. +10 more
core +2 more sources
Therapeutic approaches with intravitreal injections in geographic atrophy secondary to age-related macular degeneration: current drugs and potential molecules [PDF]
, 2019 The present review focuses on recent clinical trials that analyze the efficacy of intravitreal therapeutic agents for the treatment of dry age-related macular degeneration (AMD), such as neuroprotective drugs, and complement inhibitors, also called ...
Cerini, Alberto +5 more
core +1 more source
Interventions for neovascular age-related macular degeneration
Cochrane Database of Systematic Reviews, 2009 Reason for withdrawal from publication In the light of current guidelines on macular degeneration being developed by NICE, CEV considers that this overview will not provide enough additional information to be a useful piece of work at this stage.
Catey Bunce +6 more
openaire +3 more sources
Advanced Science, EarlyView.PD‐L1 limits neuroinflammation in neovascular AMD by modulating microglial activation. Its deficiency exacerbates vascular leakage and choroidal neovascularization (CNV) via ERK signaling, while enhancing PD‐L1 reduces inflammation and neovascularization. Targeting PD‐L1 may offer a novel immunomodulatory strategy for NVAMD.
Yue Zou +7 more
wiley +1 more source