Results 81 to 90 of about 31,226 (229)

A Cationic Block Co‐Polymer for Gene Delivery in the Posterior Segment of the Eye

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
ABSTRACT Diseases of the back of the eye such as neovascular age‐related macular degeneration (nAMD) are vision threatening and treatment is burdensome for patients, often requiring ocular injections every other month. Injection risks and logistics lower patient compliance; however, even patients receiving optimal treatment can deteriorate.
Amber Monteiro, Odunayo O. Mugisho, Antonio de Souza, Lina Liu, Yosra Agban, Priyanka Agarwal, Avik Shome, Ilva D. Rupenthal, Heather Sheardown   +8 more
wiley   +1 more source

Novel computer-based assessments of everyday visual function in people with age-related macular degeneration.

PLoS ONE, 2020
PurposeTo test the hypothesis that the performance in novel computer-based tasks of everyday visual function worsens with disease severity in people with non-neovascular age-related macular degeneration.MethodsParticipants with and without non ...
Bethany E Higgins, Deanna J Taylor, Wei Bi, Alison M Binns, David P Crabb   +4 more
doaj   +1 more source

Ordered subset linkage analysis supports a susceptibility locus for age-related macular degeneration on chromosome 16p12 [PDF]

, 2004
Background Age-related macular degeneration (AMD) is a complex disorder that is responsible for the majority of central vision loss in older adults living in developed countries. Phenotypic and genetic heterogeneity complicate the analysis of genome-wide
Agarwal Anita, De La Paz Monica A, Gilbert John R, Gorin Michael B, Haines Jonathan L, Hauser Elizabeth R, Pericak-Vance Margaret A, Postel Eric A, Schmidt Silke, Scott William K, Weeks Daniel E   +10 more
core   +3 more sources

Decellularized Aged Bruch's Membrane Confers Unique Biochemical Cues to Retinal Pigment Epithelium for In Vitro Modeling of Age‐Related Macular Degeneration

Aging Cell, Volume 25, Issue 5, May 2026.
A Bruchs membrane (BrM) mimic based on aged decellularized BrM was developed and differentially expressed proteins in aged dECM‐BrM that may provide specific biochemical cues fundamental to model AMD in vitro were identified. RPE culture on aged dECM‐BrM developed certain AMD‐like features including reduced TEER and expression of drusen components ...
Blanca Molins, Mercedes Soledad Nabaes Jodar, Eliandre de Oliveira, Josep Maria Estanyol, Esther Peña, Jaione Bezunartea, María Hernández, Marc Figueras‐Roca, Alfredo Adan   +8 more
wiley   +1 more source

Brolucizumab for Neovascular Age-Related Macular Degeneration (BEL Study)

Clinical Ophthalmology, 2023
Liesbeth Van Cleemput,1,2 Freya Peeters,1,2 Julie Jacob1,2 1Department of Ophthalmology, University Hospital Leuven, Leuven, Belgium; 2Research Group Ophthalmology, Department of Neurosciences, KU Leuven, Leuven, BelgiumCorrespondence: Liesbeth Van ...
Van Cleemput L, Peeters F, Jacob J
doaj  

Functional Outcomes of the Low Vision Depression Prevention Trial in Age-Related Macular Degeneration. [PDF]

, 2017
Purpose: To compare the efficacy of behavioral activation (BA) plus low vision rehabilitation with an occupational therapist (OT-LVR) with supportive therapy (ST) on visual function in patients with age-related macular degeneration (AMD). Methods: Single-
Casten, Robin J., Deemer, Ashley D., Massof, Robert W., Piersol, Catherine V., Rovner, Barry W.   +4 more
core   +3 more sources

Real‐world outcomes of aflibercept 8 mg in patients previously treated for neovascular age‐related macular degeneration

Acta Ophthalmologica, Volume 104, Issue 3, Page 296-304, May 2026.
Abstract Purpose To evaluate visual, anatomical and safety outcomes of aflibercept 8 mg in previously treated patients with neovascular age‐related macular degeneration (nAMD). Methods This retrospective study included nAMD patients switched to aflibercept 8 mg from prior anti‐VEGF therapies at Sahlgrenska University Hospital between February 2024 and ...
Imadeddin Abu Ishkheidem, Esra Inci, Martin Breimer, Sofia Töyrä Silfverswärd, Madeleine Zetterberg, Marita Andersson Grönlund   +5 more
wiley   +1 more source

Visual Performance in Patients with Neovascular Age-Related Macular Degeneration Undergoing Treatment with Intravitreal Ranibizumab [PDF]

, 2013
This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Purpose.
Beatty, S, Loughman, J, Meagher, K A, Nolan, J M, Pesudovs, Konrad, Sabour-Pickett, S, Stack, J   +6 more
core   +3 more sources

Fluid/function correlation using AI‐based quantification versus central subfield thickness in treatment‐naïve and pre‐treated patients with neovascular AMD in a real‐world setting

Acta Ophthalmologica, Volume 104, Issue 3, Page 305-313, May 2026.
Abstract Purpose To investigate the association between best‐corrected visual acuity (BCVA) and quantitative macular fluid volumes, compared to central subfield thickness (CST) in treatment‐naïve and previously treated patients with active neovascular age‐related macular degeneration (nAMD).
Anna Eidenberger, Gregor S. Reiter, Virginia Mares, Sophie Frank‐Publig, Philipp Fuchs, Magdalena Baratsits, Markus Gumpinger, Georg Faustmann, Alexandra Miere, Catherine Creuzot‐Garcher, Ulrike Scheschy, Laurent Kodjikian, Vincent Gualino, Benjamin Wolff, Stefan Sacu, Ursula Schmidt‐Erfurth   +15 more
wiley   +1 more source

Cutting Edge Advancements in Management of Neovascular Age-Related Macular Degeneration A Scoping Review on Gene Therapy

IJRETINA (International Journal of Retina)
Introduction: Age-related macular degeneration (AMD) is the fourth leading cause of blindness globally. Therapeutic strategies for neovascular AMD (nAMD) have utilized anti-VEGF proteins, however compliance has become an issue. This study aims to explore
Diannisa Paramita Susantono, Andi Arus Victor   +1 more
doaj   +1 more source