Results 101 to 110 of about 34,514 (311)

Bevacizumab as a treatment option in gastrointestinal bleeding associated to hereditary hemorrhagic telangiectasia. Case Report

Revista de la Facultad de Medicina, 2019
Introduction: Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant genetic disease characterized by the presence of arteriovenous malformations in the nasal mucosa, the tips of fingers, and sometimes in the lungs, the gastrointestinal ...
Erwing Castillo, Jeanette Prada-Arismendy   +1 more
doaj   +1 more source

Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology [PDF]

, 2018
SUMMARY: Identification of carotid artery atherosclerosis is conventionally based on measurements of luminal stenosis and surface irregularities using in vivo imaging techniques including sonography, CT and MR angiography, and digital subtraction ...
Balu, N, DeMarco, JK, Fan, Z, Hatsukami, TS, Johnson, MH, Jäger, HR, Jäger, HR, Kooi, ME, Li, D, Matouk, CC, Mikulis, DJ, Moody, AR, Mossa-Basha, M, Qiao, Y, Saam, T, Saba, L, Saloner, D, Vessel Wall Imaging Study Group of the American Society of Neuroradiology, Wasserman, BA, Wintermark, M, Yuan, C   +20 more
core   +2 more sources

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis

Advanced Science, EarlyView.
This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen, Hao Shi, Junxian He, Ziyu Liu, Yuanyuan Zhu, Xiaoyan Liang, Guihua Liu, Xing Yang   +7 more
wiley   +1 more source

Distinct Immunomodulatory Strategies Guide Mesenchymal Stromal/Stem Cell‐Mediated Bone Regeneration

Advanced Science, EarlyView.
Bone regeneration by mesenchymal stem cells is strongly influenced by immune signals. This study shows that priming stem cells with regulatory immune cells or an inflammation‐resolving lipid molecule enhances bone formation through distinct immune pathways.
Salwa Suliman, Carla Alvarez Rivas, Aashish Srivastava, Nora Marek, Kamal Mustafa, Alpdogan Kantarci   +5 more
wiley   +1 more source

The Neurotrophic Receptor Ntrk2 Directs Lymphoid Tissue Neovascularization during Leishmania donovani Infection [PDF]

, 2015
The neurotrophic tyrosine kinase receptor type 2 (Ntrk2, also known as TrkB) and its ligands brain derived neurotrophic factor (Bdnf), neurotrophin-4 (NT-4/5), and neurotrophin-3 (NT-3) are known primarily for their multiple effects on neuronal ...
A Mansson-Broberg, Alun Kirby, Amy C. Glover, B Cristofaro, C Brand, C Cursiefen, C Sunderkotter, CA Benedict, CR Engwerda, D Neri, DA Hume, DA Hume, DM Smadja, E Giraudo, E Scandella, EE Zijlstra, Eng-Kiat Lim, ET Cadman, F Pipp, FM Vassoler, G Diez-Roux, I Arnaoutova, IB Lobov, JA Vega, Jane E. Dalton, JE Dalton, JR Jackson, JW Pollard, K Oguma, L Beattie, L Serghides, Laura Hoodless, LE Benjamin, LS Ojalvo, Lynette Beattie, M Cazorla, M Kerschensteiner, M Perez-Perez, M Zeng, M Zeng, MJ Donovan, MJ Donovan, P Carmeliet, P Kermani, P Kermani, P Paulus, P Yurdakul, Paul M. Kaye, PM Kaye, PM Martinelli, R Heidenreich, R Iyer, R Phillips, Ricardo T Gazzinelli, S Aharinejad, S Gazzaniga, S Mayeur, S Rao, SN Mueller, T Barichello, TB Geijtenbeek, WV Ingman   +61 more
core   +3 more sources

Management of Choroidal Neovascularization Secondary to Pathological Myopia

Asia-Pacific Journal of Ophthalmology, 2014
Choroidal neovascularization (CNV) secondary to pathological myopia is an important cause of significant visual impairment in young adults. High myopia is particularly prevalent in Asian population. New scientific contributions have been made to the understanding of high myopia and myopic CNV.
Mary, Ho, David T L, Liu, Alvin L, Young, Dennis S C, Lam   +3 more
openaire   +2 more sources

A BioLiving Periosteum Evokes Centripetal Regeneration in Challenging Bone Defects

Advanced Science, EarlyView.
Large bone defects often suffer from insufficient central healing. This study engineers a BioLiving periosteum that mimics the native structure. It sequentially delivers remote chemical cues and contact physical cues in a signaling‐relay manner, effectively recruiting and guiding endogenous cells toward the defect center.
Yang Shi, Nian Liu, Jingyi Gu, Yinling Wang, Weiye Wang, Zhiwei Ke, Mingjun Xie, Wenjing Jin, Weicheng Kong, Jue Shi, Hui Pan, Yong He, Zhijian Xie   +12 more
wiley   +1 more source

Intravitreal aflibercept for the treatment of choroidal neovascularization associated with pathologic myopia: a pilot study

Clinical Ophthalmology, 2016
Andrii R Korol, Oleg S Zadorozhnyy, Volodymyr O Naumenko, Taras B Kustryn, Nataliya V Pasyechnikova The Filatov Institute of Eye Diseases and Tissue Therapy of the National Academy of Medical Sciences of Ukraine, Odessa, Ukraine Purpose: To determine ...
Korol AR, Zadorozhnyy OS, Naumenko VO, Kustryn TB, Pasyechnikova NV   +4 more
doaj  

Macular and Optic Disc Edema and Retinal Vascular Leakage in Familial Amyloid Polyneuropathy with a Transthyretin Val30Met Mutation: a Case Report [PDF]

, 2014
Introduction: Familial amyloid polyneuropathy is a group of autosomal dominant disorders characterized by extracellular amyloid deposition in several target organs. This paper aims to report an unusual manifestation of retinal vascular leakage including
Cunha, JP, Dias-Santos, A, Ferreira, J
core   +2 more sources