Results 111 to 120 of about 34,514 (311)
Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes
Advanced Science, EarlyView.This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin +2 more
wiley +1 more source
Journal of Ophthalmology, 2016 Purpose: To determine the efficacy of ranibizumab as a treatment for subretinal neovascularization (SRNV) in pathologic myopia. Materials and Methods: This was an uncontrolled, prospective cohort study, involving 66 pathologic myopic eyes (65 patients)
О.M. Blavatska, T.B. Kustry, A.R. Korol
doaj +1 more source
Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation
Advanced Science, EarlyView.An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng +10 more
wiley +1 more source
Retinal pigment epithelial tears after intravitreal bevacizumab injection for exudative age-related macular degeneration. [PDF]
, 2008 PURPOSE: To determine the incidence of and the risk factors for the development of retinal pigment epithelial (RPE) tears after intravitreal bevacizumab (Avastin) injection for the treatment of exudative age-related macular degeneration (AMD). METHODS: A
Brod, Roy +5 more
core +2 more sources
Microglia in pathological neovascularization in the retina
, 2017 INTRODUCTION. Mononuclear phagocytes (e.g. microglia, macrophages) have been characterized as potential mediators of retinal neovascularization and degeneration. In vivo assessments of mononuclear phagocyte behavior in animals provides an important insight into disease that improves the understanding of pathological mechanisms and helps to approach new
openaire +1 more source
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
Galectin-1 expression imprints a neurovascular phenotype in proliferative retinopathies and delineates responses to anti-VEGF [PDF]
, 2017 Neovascular retinopathies are leading causes of irreversible blindness. Although vascular endothelial growth factor (VEGF) inhibitors have been established as the mainstay of current treatment, clinical management of these diseases is still limited.
Croci Russo, Diego Omar +9 more
core +1 more source
Advanced Science, EarlyView.ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu +15 more
wiley +1 more source
The Diagnostic Accuracy of Abdominal Ultrasound Imaging for Detection of Ovarian Masses [PDF]
Background/Objective: Detection of the tissue diagnosis of ovarian space occupying lesions (OSOL) has remained a challenging task for sonographers since many adnexal masses have nonspecific sonographic appearances.
رفاهی, سهیلا +2 more
core
Experimental inhibition of proliferative retinopathy [PDF]
, 2012 Retinal ischemic diseases like retinopathy of prematurity (ROP), diabetic retinopathy (DRP) and retinal vein occlusion, with preretinal neovascularization (angiogenesis) that may lead to vitreous hemorrhages and retinal detachment with subsequent vision ...
Almlöf Sarman, Sylvia
core +1 more source