Results 131 to 140 of about 125,954 (295)

Differences between pathologic and non-pathologic high myopia in 4-year outcomes of anti-VEGF therapy for macular neovascularization

Scientific Reports
This retrospective observational study aimed to investigate the difference in 4-year outcomes of ranibizumab or aflibercept therapy for macular neovascularization (MNV) with high myopia between pathologic myopia (PM) and non-PM.
Yuki Honda, Manabu Miyata, Masahiro Miyake, Masayuki Hata, Shogo Numa, Yuki Mori, Sotaro Ooto, Hiroshi Tamura, Naoko Ueda-Arakawa, Yuki Muraoka, Ayako Takahashi, Keina Sado, Ai Kido, Akitaka Tsujikawa   +13 more
doaj   +1 more source

Intrasplenic Thymus Organogenesis from Injectable Tissue Fragments Restores Functional T‐Cell Immunity

Advanced Science, EarlyView.
Clinical intramuscular thymus transplantation yields only short‐lived efficacy and marginal therapeutic benefits. Benefiting from the spleen's intrinsic strengths—rapid vascular perfusion, abundant developmental factors, and resident progenitors—the intrasplenic thymic grafts achieve robust thymic regeneration and substantial T‐cell reconstitution ...
Shaocong Wang, Zijian Zhang, Fulin Dai, Zhijie Yin, Zhen Xing, Yurong Li, Haochong Lei, Junfeng Zhang, Chunyan Liu, Yan Li, Lei Dong   +10 more
wiley   +1 more source

Both Radiofrequency Microtenotomy and Physical Therapy Provide Significant Improvements in Patients With Chronic Midportion Achilles Tendinopathy at a Minimum 5‐Year Follow‐Up

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate a minimum 5‐year follow‐up of patients who were treated with either bipolar radiofrequency microtenotomy (RFM) or physical therapy (PT) for midportion Achilles tendinopathy between 2016 and 2018. Methods All subjects who participated in a previous randomized controlled trial (n = 38) between 2016 and 2018 were invited to fill out a ...
Hayat Jirde Ali, Khaled Meknas, Jüri‐Toomas Kartus, Dana Meknas   +3 more
wiley   +1 more source

Verteporfin photodynamic therapy for subfoveal choroidal neovascularization in pathologic myopia: A 12-month retrospective review

, 2008
PURPOSE: To evaluate the visual outcome of patients with subfoveal choroidal neovascularization (CNV) secondary to pathologic myopia treated with verteporfin photodynamic therapy (PDT-V) and to verify the predictive role of visual and angiographic ...
PARMEGGIANI F., RINALDI M., DELLA CORTE M., SEMERARO, Francesco, INCORVAIA C., CAMPA C., MENZIONE M., ROMANO M. R., COSTAGLIOLA C.   +8 more
core   +1 more source

Mast cells promote choroidal neovascularization in a model of age-related macular degeneration

Journal of Neuroinflammation
‘Wet’ age-related macular degeneration (AMD) is characterized by pathologic choroidal neovascularization (CNV) that destroys central vision. Abundant evidence points to inflammation and immune cell dysfunction in the progression of CNV in AMD. Mast cells
Rabah Dabouz, Pénélope Abram, Jose Carlos Rivera, Sylvain Chemtob   +3 more
doaj   +1 more source

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Pegaptanib sodium for ocular vascular disease

Indian Journal of Ophthalmology, 2007
Pegaptanib sodium (Macugen™) is a selective RNA aptamer that inhibits vascular endothelial growth factor (VEGF) 165 , the VEGF isoform primarily responsible for pathologic ocular neovascularization and vascular permeability, while sparing the ...
Shukla Dhananjay, Namperumalsamy Perumalsamy, Goldbaum Mauro, Cunningham Jr Emmett   +3 more
doaj  

Inhibition of pathological retinal neovascularization by semaphorin 3A.

Molecular vision, 2013
Pathological retinal angiogenesis is a major cause of vision loss. Semaphorin 3A (Sema3A), a chemorepellent guidance protein, plays crucial roles in neural and vascular patterning. To identify its role in retinal neovascularization, we investigated its antiangiogenic effects.Human umbilical vein endothelial cells (HUVECs) were used for the in vitro ...
Wenzhen, Yu, Yujing, Bai, Na, Han, Fei, Wang, Min, Zhao, Lvzhen, Huang, Xiaoxin, Li   +6 more
openaire   +1 more source

Cost–benefit analysis of screening programme for diabetic retinopathy in Bulgaria

British Journal of Clinical Pharmacology, EarlyView.
Aims Late‐diagnosed diabetic retinopathy (DR) is difficult and expensive to treat. Screening programmes can identify the disease early and reduce the costs of its future treatment. This study aims to analyse the cost–benefit of screening programmes for DR.
Iva Nenkova, Yoana Lilova, Alexander Oscar, Alina Levi, Maria Kamusheva, Guenka Petrova   +5 more
wiley   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source